Result for
Topic: Testing and Treatment
March 13, 2020
A Novel Approach for a Novel Pathogen: using a home assessment team to evaluate patients for 2019 novel coronavirus (SARS-CoV-2)
This report summarizes the innovative approach of using home assessment to provide real-time clinical evaluation of patients who do not require emergency medical care or hospitalization, a process originally developed for the 2014 Ebola response by the Harborview Medical Center and Public Health Seattle King County. This tool benefits both the public health and clinical…
March 11, 2020
Rapid Detection of 2019 Novel Coronavirus SARS-CoV-2 Using a CRISPR-based DETECTR Lateral Flow Assay
Researchers tested a new CRISPR-based DETECTR Lateral Flow Assay (CRISPR-Cas12) and found it to perform comparably to the US CDC SARS-CoV-2 real time RT-PCR assay. Broughton et al. (Mar 10, 2020). Rapid Detection of 2019 Novel Coronavirus SARS-CoV-2 Using a CRISPR-based DETECTR Lateral Flow Assay. Pre-print downloaded Mar 11 from https://doi.org/10.1101/2020.03.06.20032334
March 10, 2020
Of chloroquine and COVID-19
Touret and Lamballerie provide a commentary on studies that demonstrated benefits of chloroquine phosphate in inhibiting the exacerbation of pneumonia, improving lung imaging findings, promoting a virus negative conversion, and shortening the disease course. They however caution against drawing definitive conclusions without a clinical trial. Touret and Lamballerie (Mar 2, 2020). Of chloroquine and COVID-19….
Diagnostic Testing for the Novel Coronavirus
Sharfstein et al discuss the race against time to discover new and better diagnostic tools and the technical challenges of the tests developed by CDC for diagnosis of COVID-19. They discuss the regulatory structures for diagnostic tests and draw distinction between testing capacity for public surveillance and clinical care. Some of the challenges encountered by…
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model
Fan et al repurposed clinically approved drugs for the treatment of COVID-19, reporting that cepharanthine (CEP), selamectin, and mefloquine hydrochloride exhibited complete inhibition of cytopathic effects in cell culture at 10 μmol/L and should be considered potential drugs for treating SARS-CoV-2 infection. Clinical trials are needed. Fan et al. (Mar 6, 2020). Repurposing of clinically…
March 5, 2020
Covert COVID-19 and false-positive dengue serology in Singapore
A COVID-19 patient in Singapore was initially misdiagnosed by a false-positive dengue rapid test, underscoring the importance of formalizing rapid and accessible diagnostic tests with high sensitivity and specificity. Yan et al. (Mar 4, 2020). Covert COVID-19 and false-positive dengue serology in Singapore. Lancet Infect Dis. https://doi.org/10.1016/S1473-3099(20)30158-4
March 3, 2020
Convalescent plasma as a potential therapy for COVID-19
Another study has drawn attention to the possibility of convalescent plasma as a treatment option for COVID-19, calling for further safety and efficacy testing. Chen et al. (Feb 27, 2020). Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis. https://doi.org/10.1016/S1473-3099(20)30141-9
Clinical significance of IgM and IgG test for diagnosis of highly suspected COVID-19 infection
A study of 57 patients, some with and some without confirmed COVID-19, was conducted to assess the accuracy and utility of IgM and IgG serological testing. Jia et al. (Mar 3, 2020). Clinical significance of IgM and IgG test for diagnosis of highly suspected COVID-19 infection. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2020.02.28.20029025
Laboratory abnormalities in patients with COVID-2019 infection
This paper offers a review of current literature on laboratory considerations for testing for COVID-19 and descriptions of specific abnormalities used for diagnostic and prognostic decisions. Lippi and Plebani (Mar 3, 2020). Laboratory abnormalities in patients with COVID-2019 infection. CCLM. https://doi.org/10.1515/cclm-2020-0198
Rapid Detection of SARS-CoV-2 Using Reverse transcription RT-LAMP method
This study evaluated the use of RT-LAMP for diagnosing COVID-19. Sensitivity was similar to RT-PCR and specificity was 99%. Yang et al. (Mar 2, 2020). Rapid Detection of SARS-CoV-2 Using Reverse transcription RT-LAMP method. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2020.03.02.20030130
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