Result for
Topic: Testing and Treatment
March 3, 2020
Fecal specimen diagnosis 2019 Novel Coronavirus–Infected Pneumonia
A case series study found that fecal specimens were equally accurate in detecting SARS-CoV-2 compared to nucleic acid tests. Patients with positive stool samples did not exhibit gastrointestinal symptoms and presence of the virus in the stool was not associated with the severity of lung infection. Zhang et al. (Mar 3, 2020). Fecal specimen diagnosis…
Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019
Seroconversion was evaluated for 173 COVID-19 patients in China. Less than 40% of patients showed presence of antibodies during the first 7 days of illness, but this rapidly increased over subsequent days to 100% (Ab), 94.3% (IgM), and 79.8% (IgG). Combining RNA and antibody tests significantly improved diagnostic sensitivity, even in the first 7 days…
March 2, 2020
Clinical trial analysis of 2019-nCoV therapy registered in China
Zhang et al summarize clinical trials for potential COVID-19 treatment options. Zhang et al. (Feb 28, 2020) Clinical trial analysis of 2019-nCoV therapy registered in China. J Med Virol. https://doi.org/10.1002/jmv.25733
A Well Infant with Coronavirus Disease 2019 (COVID-19) with High Viral Load
An asymptomatic 6-month old infant was hospitalized with COVID-19 and had positive nasopharyngeal swabs 16 days after admission. The case highlights potential flaws in current symptom-centric case definitions, especially in infants. Kam et al. (Feb 28, 2020). A Well Infant with Coronavirus Disease 2019 (COVID-19) with High Viral Load. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa201
Evaluation of Enzyme-Linked Immunoassay and Colloidal Gold- Immunochromatographic Assay Kit for Detection of Novel Coronavirus (SARS-Cov-2) Causing an Outbreak of Pneumonia (COVID-19)
Xiang et al present sensitivity and specificity of ELISA and GICA IgM and IgG serological assays for COVID-19 detection, noting that these tests may be useful alternatives to current PCR-based methods. Xiang et al. (March 1, 2020). Evaluation of Enzyme-Linked Immunoassay and Colloidal Gold- Immunochromatographic Assay Kit for Detection of Novel Coronavirus (SARS-Cov-2) Causing an…
Deep learning-based model for detecting 2019 novel coronavirus pneumonia on high-resolution computed tomography: a prospective study
A new deep learning-based system was found to have 100% sensitivity and 93.55% specificity (PPV 84.62%) in detecting COVID-19 from CT scans. The model performed comparably to an expert radiologist, and combined with expert review the model decreased CT reading time by 65%. Chen et al. (Mar 1, 2020). Deep learning-based model for detecting 2019…
Prediction of survival for severe Covid-19 patients with three clinical features: development of a machine learning-based prognostic model with clinical data in Wuhan
A new machine learning prognostic model was found to have 90% accuracy in predicting mortality among COVID-19 patients based on just three clinical characteristics: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hsCRP). Yan et al. (Mar 1, 2020). Prediction of survival for severe Covid-19 patients with three clinical features: development of a machine learning-based…
February 12, 2020
Laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections
The diagnostic accuracy of different respiratory specimens for 2019-nCoV detection is assessed by Yang, et al. Specimens were collected from confirmed novel coronavirus pneumonia (NCP; severe or mild) patients in a Guangdong, China hospital; and tested using the Qiagen QIAamp RNA Viral Kit and a Chinese Food & Drug Administration-approved, quantitative RT-PCR 2019-nCoV detection kit. …
COVID-19 and psoriasis: is it time to limit treatment with immunosuppressants? A call for action
The authors stress the importance of a therapeutic reassessment of all psoriatic patients because immunosuppressive drugs can weaken the immune system making these patients more susceptible to opportunistic infections. Conforti et al. (Mar 11, 2020). COVID-19 and psoriasis: is it time to limit treatment with immunosuppressants? A call for action. Dermatologic Therapy. https://doi.org/10.1111/dth.13298
February 11, 2020
Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment
A case series of four 2019-nCoV pneumonia patients admitted to the Shanghai Public Health Clinical Center is presented. Patient recruitment was 21-24 Jan, and data collection occurred through 4 Feb, 2020. All patients had mild to severe pneumonia with fever. Older patients were hospitalized for longer. Other symptoms, laboratory findings, and treatment regimens are summarized….
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