Alliance for Pandemic Preparedness

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Topic: Transmission


February 22, 2021

Clusters of SARS-CoV-2 Infection Among Elementary School Educators and Students in One School District — Georgia, December 2020–January 2021

An investigation of SARS-CoV-2 transmission in a school district in Georgia between December 1, 2020–January 22, 2021 identified nine clusters of COVID-19 cases involving 13 educators and 32 students at six of eight elementary schools. Two clusters involved probable educator-to-educator transmission that was followed by educator-to-student transmission in classrooms, resulting in approximately one half (15…


February 18, 2021

Epidemiological Dynamics of the Incidence of COVID-19 in Children and the Relationship with the Opening of Schools in Catalonia (Spain)

[Pre-print, not peer reviewed] Incidence of COVID-19 among children aged <18 years in Catalonia, Spain during the first 20 weeks of the 2020-2021 school year remained significantly lower than in the general population, except during late January 2021.  Test positivity was also lower among children than the general population, except in January 2021, when active…


February 17, 2021

Characteristics of SARS-CoV-2 Transmission among Meat Processing Workers in Nebraska, USA, and Effectiveness of Risk Mitigation Measures

There was a 19% COVID-19 attack rate (n=5,002 cases) among Nebraska meat processing workers during April 1–July 31, 2020. After implementing universal masking and physical barrier interventions, 8 of 13 facilities showed a statistically significant reduction in COVID-19 incidence in less than 10 days. While 67% of cases occurred among workers who identified as Hispanic…


February 16, 2021

S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated with Significantly Higher Viral Loads in Samples Tested by ThermoFisher TaqPath RT-QPCR

Individuals infected with the SARS-CoV-2 B.1.1.7 variant (first described in the UK) may have considerably higher viral loads, which could potentially explain the higher transmissibility of this variant. Analysis of 641 SARS-CoV-2 PCR positive samples in the UK from October to November 2020 showed that samples suspected to have the B.1.1.7 variant, identified by a…


February 13, 2021

The Effects of School Closures on SARS-CoV-2 among Parents and Teachers

Sweden kept schools open for in-person instruction for younger students (primary and lower-secondary) while closing schools for older students (upper-secondary), allowing for an evaluation of school closures on SARS-CoV-2 transmission. The rate of SARS-CoV-2 infection among lower-secondary teachers (who taught children age 14 to 16 in person) was twice as high (7.4 cases per 1,000)…


February 11, 2021

Emergence of a Novel SARS-CoV-2 Variant in Southern California

A novel variant of SARS-CoV-2 called “CAL.20C” was identified in Southern California and emerged contemporaneously with a local surge in cases. The authors define the variant on the basis of three mutations in the S-protein (S13I; W152C; and L452R) which differentiate the subclade from the 20C clade currently predominant in North America. The functional effect…


Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19

SARS-CoV-2 RNA was not detected by RT-qPCR in breast milk samples (n=37) collected from 18 women following COVID-19 diagnosis. Breast milk was collected on average 12.0 +/- 8.9 days after onset of signs and/or symptoms.  In contrast, 76% and 80% of samples contained anti-SARS-CoV-2 IgA and IgG, respectively, and 62% of samples neutralized SARS-CoV-2 in…


February 10, 2021

SARS-CoV-2 Setting-Specific Transmission Rates: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis indicated that the highest SARS-CoV-2 transmission rates were within households, with a pooled secondary attack rate (SAR) of 21%. SARs were significantly higher when the duration of household exposure was longer than 5 days. SARs for contacts with family and friends were higher than those for low-risk casual contacts (6%…


February 9, 2021

SARS-CoV-2 Transmission among Children and Staff in Daycare Centres during a Nationwide Lockdown in France: A Cross-Sectional, Multicentre, Seroprevalence Study

Children (n=327) and staff (n=197) attending daycare centers in France during the lockdown from March to May 2020 had similar seroprevalence (4% and 7%, respectively) to a comparator group consisting of laboratory or administrative personnel not occupationally exposed to COVID-19 patients or children (5%). In addition, seropositive children were 7-times as likely to have been…


Risk of Hospitalisation with COVID-19 among Teachers Compared to Healthcare Workers and Other Working-Age Adults

[Pre-print, not peer-reviewed] Teachers were at 1.4-times the risk for developing SARS-CoV-2 infection compared to the general population of working-age adults, according to a population-based case-control study including all cases of adult COVID-19 in Scotland (n=83,817) during March 2020 to January 2021 and a random sample of matched controls (n=841,708). However, teachers and their household…



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