Alliance for Pandemic Preparedness

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Topic: Transmission


February 8, 2021

SARS-CoV-2 Transmission Risk from Sports Equipment (STRIKE)

[Pre-print, not peer-reviewed] A study investigating the potential of shared sporting equipment transmission vectors of SARS-CoV-2 during the reintroduction of sports found that it was unlikely that equipment is a major route of SARS-CoV-2 transmission. Ten different types of equipment were inoculated with 40μl droplets containing clinically relevant high and low concentrations of live SARS-CoV-2…


Incubation Period of COVID-19: A Meta-Analysis

A systematic review and meta-analysis of studies (n = 99) published through January 10, 2021 concluded that the average incubation period for SARS-CoV-2 was 6.4 days, with a range of 2.3 to 17.6 days. 23 cohort studies, 61 case series, and 15 modeling studies were included, most of which reported data from patients with SARS-CoV-2…


COVID-19 Transmission in Educational Institutions August to December 2020 Rhineland-Palatinate Germany a Study of Index Cases and Close Contact Cohorts

[Pre-print, not peer-reviewed] A study of SARS-CoV-2 transmission in schools and daycare centers in Germany from August-December 2020 showed that the risk of infection among contacts of a confirmed COVID-19 case was low but varied depending on type of educational institution and whether the case was a teacher or student/child. Out of 784 index cases,…


February 5, 2021

Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California

Results from a SARS-CoV-2 antibody seroprevalence survey (July 10 to August 16, 2020, n=2979) from a socioeconomically and demographically diverse population of adults in Orange County, California found a seroprevalence of approximately 12 percent. Antibody testing was conducted using a highly specific and sensitive CoVAM microarray. This SARS-CoV-2 point seroprevalence among adults for July to August…


February 4, 2021

ARS-CoV-2 Transmission from the Healthcare Setting into the Home a Prospective Longitudinal Cohort Study

[Pre-print, not peer reviewed] In cohort study  in England (n=633), seroprevalence for antibodies against SARS-CoV-2 was higher among healthcare workers (HCWs) than the general population (18% vs 7%). Longitudinal analysis showed that seroprevalence for all immunoglobins declined over time, from overall positivity of 17% to 7% within 3 months. Seroprevalence was similar between household contacts…


Mechanistic Transmission Modeling of COVID-19 on the Diamond Princess Cruise Ship Demonstrates the Importance of Aerosol Transmission

An iterative modeling study simulating the SARS-CoV-2 outbreak on the Diamond Princess cruise ship suggests that airborne transmission via larger respiratory droplets and smaller aerosols likely accounted for over half of disease transmission. From  132 out of over 20,000 model iterations that fit the epidemiological progression of the outbreak within acceptability criteria, the mean estimates…


February 3, 2021

Transmission of COVID-19 in 282 Clusters in Catalonia, Spain: A Cohort Study

The risk of transmission of COVID-19 was greater when the index case had a higher concentration of virus. A cohort study of 282 COVID-19 clusters (n=314 patients) in Spain conducted from March-April 2020 indicated that the risk of symptomatic COVID-19 was associated with the viral load of the index case. The secondary attack rate ranged…


SARS-CoV-2 Seropositivity among US Marine Recruits Attending Basic Training, United States, Spring–Fall 2020

A cross-sectional study of US Marine Recruits (n=3,249) conducted from Spring-Fall 2020 found a baseline IgG seroprevalence against SARS-Cov-2 of 9%. Participants were primarily males aged 18-20 from the Eastern US or states with large populations. Participants who identified as Hispanic or non-Hispanic Black had higher IgG prevalence (18%, OR=3.8 and 15%, OR=3.5, respectively) than…


February 2, 2021

High Variability in Transmission of SARS-CoV-2 within Households and Implications for Control

[Pre-print, not peer reviewed] A probabilistic model based upon SARS-CoV-2 antibody and PCR test data from more than 9000 Utah households estimated a 35% household secondary attack rate. In contrast, the crude estimate for household attack rate unadjusted for serological test specificity was 15%. Given the high attack rate, the authors predict that the mean…


Coronavirus Disease 2019 (COVID-19) Infection Rates in a Private School in Brooklyn, New York

COVID-19 cases were rare (0.13%) in a private school that reopened for in-person learning from October to December 2020, despite the school being in a red zone (the highest level of COVID-19 restrictions) in Brooklyn, New York. The school employed mandatory in-school SARS-CoV-2 testing using rt-PCR-confirmed nasopharyngeal swabs with a 48-72 hour turnaround time. A…



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