Result for
Topic: Transmission
December 11, 2020
High Frequency and Prevalence of Community-Based Asymptomatic SARS-CoV-2 Infection
[Pre-print, not peer reviewed] Among 730,000 SARS-CoV-2 test results from Los Angeles from August to October 2020, a higher prevalence of SARS-CoV-2 asymptomatic infection was identified among individuals who reported work in construction compared to other occupations and who identified as members of racial and ethnic minority groups. The prevalence of asymptomatic infection among Hispanic…
Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
An analysis using 772 complete SARS-CoV-2 genomes collected in Boston in February and March 2020 and genomes published by the Global Initiative on Sharing All Influenza Data found numerous introductions of the virus in the Boston area, including two superspreading events. One event was an international business conference in Boston held in February, from which…
December 10, 2020
Transmissibility of COVID-19 Depends on the Viral Load around Onset in Adult and Symptomatic Patients
In a retrospective study of 28 COVID-19 patients in Japan, median viral load at initial sample collection was significantly higher in symptomatic than asymptomatic patients, and also higher among adults than children. Among symptomatic patients (n=18), median viral load was consistently higher in patients identified as household cluster index cases than in non-index cases up…
Outbreak of SARS-CoV-2 Infection at a Large Refugee Shelter in Toronto, April 2020: A Clinical and Epidemiologic Descriptive Analysis
A high rate of SARS-CoV-2 infection was identified among residents in a large refugee shelter in Toronto in April 2020, with 25 (41.7%) of 60 adults testing positive. Only 5 (20%) residents were symptomatic at the time of testing, while 21 (87.5%) were symptomatic 14 days after testing. The authors state these results highlight the…
December 9, 2020
SARS-CoV-2 Infection and Transmission in Educational Settings: A Prospective, Cross-Sectional Analysis of Infection Clusters and Outbreaks in England
The risk of SARS-CoV-2 infections and outbreaks were low in educational settings since reopening in the summer half-term in England, with the likelihood of a school outbreak strongly associated with the regional level of COVID-19 incidence. A prospective cohort study among 57,600 educational settings in England reported that there were 113 educational settings in which…
December 8, 2020
Evaluation of Rooming-in Practice for Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Italy
It may be possible to effectively mitigate the risk of mother-to-infant transmission of SARS-CoV-2 infection, based on findings from a multi-cohort study of mother-infant dyads (n=62 neonates, 61 mothers) in Italy that found no positive results among neonates 24 hours after birth despite a 95% breastfeeding rate. Infected mothers observed contact precautions such as handwashing…
December 7, 2020
Household Factors and the Risk of Severe COVID-like Illness Early in the US Pandemic
[Pre-print, not peer-reviewed] A study of SARS-CoV-2 household transmission found that household crowding and having children in the home were both independent risk factors for being hospitalized with COVID-19 early in the pandemic in the US. COVID-19 hospitalization for households with children (versus without) was higher among study participants living in multi-unit (aOR=10.5) vs single…
A Meta-Analysis on the Role of Children in SARS-CoV-2 in Household Transmission Clusters
A meta-analysis of the role of children in SARS-CoV-2 household transmission identified 213 transmission clusters from 12 countries, and found that only 8 clusters (3.8%) had a pediatric index case. Asymptomatic index cases were associated with a lower secondary attack rate in contacts than symptomatic index cases (RR 0.17). The secondary attack rate was also…
SARS-CoV-2 RNA Detected in Blood Products from Patients with COVID-19 Is Not Associated with Infectious Virus
A systematic review of 28 studies intended to inform safety protocols for handling blood products from people with COVID-19 found there were low levels of detectable SARS-CoV-2 RNA in a minority of serum samples (pooled estimate 10%) collected during acute infection. In an associated laboratory analysis, the authors also performed RT-PCR in serum samples from a…
December 2, 2020
Evidence of Long-Distance Droplet Transmission of SARS-CoV-2 by Direct Air Flow in a Restaurant in Korea
A COVID-19 outbreak investigation at a restaurant in Jeonju, Korea revealed that one of three incident cases was infected by droplets from the index case 6.5m away within 5 minutes of exposure based on TV surveillance, interviews, and cell phone data. There was no direct or indirect contact with the index case. Ceiling-type air conditioners…
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