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Topic: Transmission
July 28, 2020
Prevalence of SARS-CoV-2 Infection Among Asymptomatic Health Care Workers in the Greater Houston, Texas, Area
A surveillance program among asymptomatic clinical and nonclinical workers at Houston Methodist (an academic medical center with 7 community hospitals), and expanded to asymptomatic community residents, found that out of 2,872 participants (March 11 to April 19) 4% tested positive for SARS-CoV-2 by RT-PCR, with all of the positive results being in clinical healthcare workers. Among clinical healthcare…
A Prospective Cohort Study in Non-Hospitalized Household Contacts with SARS-CoV-2 Infection: Symptom Profiles and Symptom Change over Time
Out of 198 household contacts exposed to SARS-CoV-2 in Wisconsin and Utah and followed longitudinally (PCR two or more times during a 14 day period) from March 22 to April 22, 47 were positive by PCR, representing an attack rate of 24%. Among children under 18 years, the attack rate was 20%, versus 26% for adults 18…
July 24, 2020
Neonatal Management and Outcomes during the COVID-19 Pandemic: An Observation Cohort Study
In a cohort study of 1,481 deliveries at New York Presbyterian Hospitals in New York City between March 22 and May 17, 116 (8%) of mothers tested positive for SARS-CoV-2, corresponding to 120 neonates. All neonates were negative for SARS-CoV-2 at 24 hours of life; of the 96% that received a repeat test at 5-7…
A Large COVID-19 Outbreak in a High School 10 Days after Schools’ Reopening, Israel, May 2020
An extensive outbreak investigation in a school (grades 7-12) in Jerusalem (Israel) found evidence of SARS-CoV-2 transmission within the school. After re-opening on May 17 after a two month closure, the first school outbreak occurred 10 days later. There was an indication that transmission was largely confined to certain grades, and to specific classrooms within those grades. As part…
July 23, 2020
Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of the COVID-19 Virus
Korber et al. present evidence that SARS-CoV-2 viruses with the G614 mutation in the Spike protein are more prevalent than the original D614 form identified in the first human cases in Wuhan, China. In a follow-up study of 999 COVID-19 patients at the Sheffield Teaching Hospitals, patients infected with G614 shed more viral nucleic acid compared with those with D614 (p=0.037), and G614-viruses show significantly higher infectious titers in vitro than their D614…
No Clear Association Emerges between Intergenerational Relationships and COVID-19 Fatality Rates from Macro-Level Analyses
Intergenerational relationships (e.g., cohabitation and contact between family members of different generations) have been hypothesized to play a role in COVID-19 spread and case fatality. Using data from 19 European counties, Arpino et al. found that at the country level, higher levels of intergenerational relationships are associated with higher COVID-19 case fatality, although the magnitude of the association is small. At the subnational level, an opposite association is often observed. The authors advocate…
July 22, 2020
Environmental Sampling for Severe Acute Respiratory Syndrome Coronavirus 2 during COVID-19 Outbreak in the Diamond Princess Cruise Ship
After sampling environmental surfaces in the Diamond Princess cruise ship, Yamagishi et al. detected SARS-CoV-2 RNA from 10% of the samples from case-cabins 1-17 days after they were vacated and detected none in non-case-cabins. Asymptomatic and symptomatic case cabins had a similar proportion of detection (21% vs 15%). No viable SARS-CoV-2 virus was isolated from any of…
SARS-CoV-2 Titers in Wastewater Are Higher than Expected from Clinically Confirmed Cases
Wu et al. tested wastewater collected at a major urban treatment facility in Massachusetts from March 18 to 25, 2020 and observed significantly higher SARS-CoV-2 titers (57 to 303 copies per mL of sewage) than expected based on number of clinically confirmed cases at the time. The investigators suggest that wastewater-based surveillance could help inform relaxing of lockdown and quarantine efforts. Wu et al. (July…
July 21, 2020
Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020
Havers et al. report a cross-sectional seroprevalence survey conducted on a convenience sample of residual sera collected from March 23 through May 12 for routine clinical testing in San Francisco (SF), Connecticut (CT), south Florida (SF), Louisiana (LA), Minneapolis-St Paul-St Cloud metro area (MN), Missouri (MS), New York City Metro Area (NYC), Philadelphia metro area (PA), Utah…
Population Point Prevalence of SARS-CoV-2 Infection Based on a Statewide Random Sample — Indiana, April 25–29, 2020
A state-wide study from Indiana conducted on a random statewide sample of non-institutionalized residents (12 years or older) from April 25-29 (n=3,658, representing a 24% response rate) estimated the prevalence of active infection, based on RT-PCR testing, was 1.7%, with 44% reporting no positive symptoms in the preceding two weeks. Estimated seropositivity was 1.1%, bringing overall prevalence of current and previous infections to 2.8%. Overall…
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