Result for
Topic: Vaccines and Immunity
April 14, 2021
Detection of SARS-CoV-2 Specific IgA in the Human Milk of COVID-19 Vaccinated Lactating Health Care Workers
[Pre-print, not peer-reviewed] SARS-CoV-2 specific IgA and IgG were detected in milk and plasma samples from 22 lactating healthcare workers who had received either the Moderna or Pfizer-BioNTech vaccines, with peak levels occurring 7-10 days after the second dose. Samples were collected prior to vaccination, after the first dose, and after the second dose in…
Survey of Behaviour Attitudes Towards Preventive Measures Following COVID-19 Vaccination
[Pre-print, not peer-reviewed] A survey of individuals vaccinated for SARS-CoV-2 in Israel found mask wearing was 21% lower and social distancing was 47% lower than before prior to vaccination, with no differences by sex. Decreases in mask wearing (28%) and social distancing (56.1%) were larger among people under age 50 than people over the age…
Adverse Events in Healthcare Workers after the First Dose of ChAdOx1 NCoV-19 or BNT162b2 MRNA COVID-19 Vaccination: A Single Center Experience
A study of 1st dose post-vaccination adverse events in Korean healthcare workers at a single hospital (N=1,483) found that adverse events were significantly more common in recipients of the Oxford/AstraZeneca vaccine (N=1,403) than the Pfizer-BioNTech vaccine (N=80). The adverse events included injection-site pain (78% vs. 51%), myalgia (61% vs. 11%), fatigue (52% vs. 8%), headache…
SARS-CoV-2 Spike E484K Mutation Reduces Antibody Neutralisation
An in-vitro study of serum from persons with either prior SARS-CoV-2 infection or two doses of the Pfizer-BioNTech vaccine (N=34) found that antibody neutralization in all samples was reduced against SARS-CoV-2 virus with a single spike E484K mutation compared to the USA-WA1/2020 strain (the strain first detected in the US). The largest reductions in antibody…
High Coverage COVID-19 MRNA Vaccination Rapidly Controls SARS-CoV-2 Transmission in Long-Term Care Facilities
[Pre-print, not peer-reviewed] A study comparing documented SARS-CoV-2 infections and deaths in Spain to counterfactual model predictions from February 6 to March 28, 2021 estimated that after 70% of long-term care facility residents had been fully vaccinated with the Pfizer-BioNTech vaccine, 74% of COVID-19 deaths and 75% of all documented infections were prevented, and transmission…
April 13, 2021
Factors Affecting Nurses’ Intention to Accept the COVID-9 Vaccine: A Cross-sectional Study
40% of nurses in Palestine reported planning to get a COVID-19 vaccine, according to a cross-sectional survey (n=639) conducted in January 2021. 41% would take it later when further protection and safety data were presented, and 18% would never take it. Preference for “natural immunity” and lack of vaccine knowledge were most strongly associated with…
SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women
Vaccine-induced SARS-CoV-2-specific antibodies were found in a high proportion of breastmilk samples obtained up to 6 weeks post-vaccination from breastfeeding women in a cohort study in Israel (n=84,504 total samples). IgA antibody positivity peaked at 86% of samples at week 4 (1 week after second dose) and remained at 66% by week 6. IgG antibody…
Age-Dependence of Healthcare Interventions for COVID-19 in Ontario, Canada
More than half of people who died of COVID-19 in Ontario, Canada (3,475 of 6,728) had no record of hospitalization for treatment related to COVID-19 (up to February 2021). Hospitalizations were relatively uniform between ages 60-90 years, while deaths were more concentrated in ages 80 and above. Using a generalized linear model, the estimated probability…
Rapid Decline of Neutralizing Antibodies Is Associated with Decay of IgM in Adults Recovered from Mild COVID-19 Disease
SARS-CoV-2-specific IgG antibody levels were relatively stable for up to 6 months, whereas neutralizing antibody responses waned during that time, according to a cohort study of 34 adults with mild COVID-19. By 6 months, only 70% (23 of 33) of participants exhibited a neutralizing response compared to 91% or higher for IgG antibody responses. Presence…
SARS-CoV-2 Infection Rates of Antibody-Positive Compared with Antibody-Negative Health-Care Workers in England: A Large, Multicentre, Prospective Cohort Study (SIREN)
Prior SARS-CoV-2 infection was associated with an 84% lower risk of new infection according to the SIREN Study, a large multi-center prospective study conducted in the UK from June to December 2020. During the study period, 155 potential reinfections were detected among 8,278 participants positive at baseline compared to 1,704 new PCR positive infections detected…
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