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Topic: Vaccines and Immunity
October 27, 2020
Longitudinal Observation and Decline of Neutralizing Antibody Responses in the Three Months Following SARS-CoV-2 Infection in Humans
A longitudinal study that followed 65 SARS-CoV-2 infected individuals up to 94 days post onset of symptoms found that the neutralizing antibody (nAb) response to SARS-CoV-2 is typical of an acute viral infection, with an initial peak whose magnitude is dependent upon disease severity, followed by declining titers. Some infected individuals with a high peak…
October 26, 2020
Social Media and Vaccine Hesitancy
Communities with a greater use of social media to organize offline political actions had more public concerns about vaccine safety in a cross-national analysis of social media and vaccine hesitancy. Additionally, foreign disinformation campaigns were found to be significantly associated with declining vaccination rates. The study found that a one-point shift upward in the five-point…
October 21, 2020
Factors Associated With US Adults’ Likelihood of Accepting COVID-19 Vaccination
A survey conducted in July, 2020 among a convenience sample of 1,971 US adults reported that preferences related to a hypothetical COVID-19 vaccine were associated with vaccine attributes (e.g., vaccine efficacy, adverse effects, and protection duration) and political factors (e.g., US FDA approval process, national origin of vaccine, and endorsements). Willingness to receive a vaccination…
Seroprevalence of Anti‐SARS‐CoV‐2 Antibodies in COVID‐19 Patients and Healthy Volunteers up to Six Months Post Disease Onset
A study among patients who tested positive for SARS-CoV-2 by PCR reported an increase in the detection of antibodies against the SARS-CoV-2 receptor binding domain (RBD) and spike protein using ELISA rapidly during the acute phase after infection, with a peak in detection around week 3. The detection of IgG antibodies remained robust, with confirmed…
October 20, 2020
Caregiver Willingness to Vaccinate Their Children against COVID-19: Cross Sectional Survey
An international cross-sectional survey of 1,541 caregivers responsible for care of a child recruited from pediatric clinics conducted from March to May 2020 found that 65% had intentions to vaccinate their child against COVID-19. An intention to vaccinate was more common among caregivers with older children, children with no chronic illness, when fathers complete the…
October 19, 2020
Herd Immunity and Implications for SARS-CoV-2 Control
An infection-based herd immunity approach, in which low-risk groups become infected while higher-risk groups are sheltered, has been proposed as a strategy for response to the SARS-CoV-2 pandemic. Omer et al. describe methods for estimating the herd immunity threshold and estimate a SARS-CoV-2 herd immunity threshold of 50-67%. Because most, if not all of the…
Weak Correlation between Antibody Titers and Neutralizing Activity in Sera from SARS‐CoV‐2 Infected Subjects
Criscuolo et al. found a poor direct correlation between anti-SARS-CoV-2 antibody titers and neutralizing activity levels against a clinical isolate of SARS-CoV-2. The authors suggest these findings highlight a need for future investigations into the role of neutralizing antibodies and their correlation with protection. In keeping with earlier studies, two commercial serology tests by DiaSorin…
Parents’ and Guardians’ Views on the Acceptability of a Future Covid-19 Vaccine a Multi-Methods Study in England
[Pre-print, not peer-reviewed] Most participants in an acceptability study of a future COVID-19 vaccine in England reported that they would accept a SARS-CoV-2 vaccine for themselves or their child. Participants were more likely to report willingness to accept a COVID-19 vaccine for themselves than for their child and less than 4% of participants reported that…
October 16, 2020
Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG
Immunity to SARS-CoV-2 infection may be mediated through T-cells, even among those with undetectable levels of antibodies against the virus. A study of immune responses against severe SARS-CoV-2 among a group of convalescent, potential blood donors in Germany found T-cell immunity against SARS-CoV-2 in 78% of volunteers who had a PCR-confirmed SARS-CoV-2 infection but had…
October 15, 2020
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
In an ongoing randomized controlled phase 1 trial of RNA-vaccine candidates BNT162b1 and BNT162b2 (n=195), both vaccine candidates elicited similar dose-dependent SARS-CoV-2 neutralizing titers, which were similar to titers of a panel of SARS-CoV-2 convalescent serum samples. BNT162b2 was associated with a lower incidence and severity of systemic reactions than BNT162b1, particularly in older adults,…
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