Research

We are engaging in quality improvement and research activities to evaluate and improve outcomes of pediatric critical illness and injury in limited-resource settings.

Our Objectives

  1. Develop research activities to characterize current prevalence and outcomes of pediatric acute illness in limited resource settings.
  2. Develop research interventions to improve outcomes in pediatric critical illness in sub-Saharan Africa.
  3. Develop pediatric severity of illness scoring systems for low-resource settings.

Recent or Ongoing Work

Feasibility of HFNC implementation for children with acute lower respiratory tract disease in rural Kenya

High-flow nasal cannula (HFNC) is a well-established respiratory support device in high-income countries, but to our knowledge, its use in sub-Saharan Africa has not been reported. This feasability study describes the implementation process of HFNC in rural Kenya. Feasibility of HFNC implementation for children with acute lower respiratory tract disease in rural Kenya- Paediatrics and International Child Health 2018

Prevalence of Acute critical Neurologic disease in children: a Global Epidemiological Assessment – Developing Countries (PANGEA-DC)

This prospective multi-center trial, funded by the Laerdal Foundation, and conducted in several developing countries surveyed the prevalence, interventions, outcomes, and barriers to emergency and supportive care for children with traumatic brain injury and acute neurologic infections. Kenyatta National Hospital/ University of Nairobi served as one of the study sites managed by a PECC collaborative research team from University of Nairobi and University of Washington. Fink – Traumatic Brain Injury and Infectious Encephalopathy in Children From Four Resource-Limited Settings in Africa – PCCM 2018 

Improving outcomes of critically-ill children in sub-Saharan Africa

The PECC team has implemented pilot studies on improved inpatient monitoring of critically-ill children at Kenyatta National Hospital/University of Nairobi and on use of High-Flow-Nasal-Cannula respiratory support for children with acute lower respiratory disease at AIC Kijabe Hospital. Both studies were funded by the Seattle Children’s Center for Clinical and Translational Research.

WFPICCS poster 5-31-18

KPA e-poster 4-23-18