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Gurusamy Balakrishnan
Research Scientist III
Bagley 411, Department of Chemistry
University Of Washington, Seattle, WA 98195


 Ph.D. in Physical Chemistry, Indian Institute of Science, Bangalore, India, 8/91 to 11/97
 M.Sc. in Chemistry, The American College, Madurai, India, 7/89 to 5/91, 1st class
 B.Sc. in Chemistry (Physics/Math minors), The American College, Madurai, India, 7/85 to 5/88, 1st class


Danish Natural Science Research Council Post-doctoral fellowship, 1/98 to 12/98
Recipient of CISR Junior and Senior Research Fellowship (JRF & SRF), 1991 - 1996


Xue, Y.; Davis, A.V.; Balakrishnan, G.; Stasser, J. P., Staehlin, B. M.; Focia, P.; Spiro, T. G.; Penner-Hahn, J. E.; O'Halloran, T.V. "Cu(I) recognition via cation-pi and methionine interactions in CusF" Nat. Chem. Biol. 2008, 107-109
Balakrishnan, G.; Hu, Y.; Bender, G. M.; Getahun, Z.; DeGrado, W. F.; Spiro, T. G. "Enthalpic and entropic stages in alpha-helical peptide unfolding, from laser T-Jump/UV raman spectroscopy" J. Am. Chem. Soc. 2007, 129 12801-12808.
Balakrishnan, G.; Hu, Y.; Oyerinde, O.F.; Su, J.; Groves, J.T.; Spiro, T.G. "A conformational switch to β-sheet structure in cytochrome c leads to heme exposure. Implications for cardiolipin peroxidation and apoptosis" J. Am. Chem. Soc. 2007, 129, 504-505.
Balakrishnan, G.; Hu, Y.; Case, M.A.; Spiro, T.G. "Microsecond Melting of a Folding Intermediate in a Coiled-Coil Peptide, Monitored by T-jump/UV Raman Spectroscopy" J. Phys. Chem. B 2006, 110, 19877-19883.
Balakrishnan, G.; Hu, Y.; Spiro, T.G. "Temperature-jump apparatus with Raman detection based on a solid-state tunable (1.80-2.05 μm) kHz optical parametric oscillator laser" Appl. Spectros. 2006, 60, 347-351.
Huang, C.Y.; Balakrishnan, G.; Spiro, T.G. "Protein secondary structure from deep-UV resonance Raman spectroscopy" J. Raman Spectros. 2006, 37, 277-282.
Kneipp, J.; Balakrishnan, G.; Chen, R.; Shen, T.-J.; Sahu, S. C.; Ho, N. T.; Giovannelli, J. L.; Simplaceanu, V.; Ho, C.; Spiro, T. G. "Dynamics of allostery in hemoglobin: Roles of the penultimate tyrosine H bonds" J. Mol. Biol. 2006, 356, 335-353.
JiJi, R. D.; Balakrishnan, G.; Hu, Y.; Spiro, T. G. "Intermediacy of poly(L-proline) II and β-strand conformations in poly(L-lysine) β-sheet formation probed by temperature-jump/UV resonance Raman spectroscopy" Biochemistry 2006, 45, 34-41.
Huang, C. Y.; Balakrishnan, G.; Spiro, T. G. "Early events in apomyoglobin unfolding probed by laser T-jump/UV resonance Raman spectroscopy” Biochemistry 2005, 44, 15734-15742.
Balakrishnan, G.; Hu, Y.; Nielsen, S.B.; Spiro, T.G. "Tunable kHz deep ultraviolet (193-210 nm) laser for Raman applications" Appl. Spectros. 2005, 59, 776-781.
Kneipp, J.; Balakrishnan, G.; Spiro, T.G. "Time-resolved resonance Raman study of HbA with 220 nm excitation: Probing phenylalanine" J. Phys. Chem. B 2004, 108, 15919-15927.
Balakrishnan, G.; Case, M.A.; Pevsner, A.; Zhao, X.; Tengroth, C.; Mclendon, G.L.; Spiro, T.G. "Time-resolved absorption and UV resonance Raman spectra reveal stepwise formation of T quaternary contacts in the allosteric pathway of hemoglobin" J. Mol. Biol. 2004, 340, 843-856.
Balakrishnan, G.; Tsai, C-H.; Wu, Q.; Case, M.A.; Pevsner, A.; Mclendon, G.L.; Ho, C.; Spiro, T.G. "Hemoglobin site-mutants reveal dynamical role of interhelical H-bonds in the allosteric pathway; Time-resolved UV resonance Raman evidence for intra-dimer coupling" J. Mol. Biol. 2004, 340, 857-868.
Puranik,M.; Nielsen, S.B.; Youn, H.; Hvitved, A.N.; Bourassa, J.L.; Case, M.A.; Tengroth, C.; Balakrishnan, G.; Thorsteinsson, M.V.; Groves, J.T.; McLendon, G.L; Roberts G.P.; Olson, J.S.; Spiro, T.G. "Dynamics of Carbon Monoxide Binding to CooA" J. Biol. Chem. 2004, 279, 21096-21108.