The YRC is a NIGMS Biomedical Technology Research Center based at the University of Washington in Seattle. Click to learn more about us.
Learn more about the technologies being developed by the YRC and how they are being applied to biomedical problems.
Learn how to collaborate with the YRC–leveraging our technology and expertise in your research.
Active Projects
Collaborators Since 2011
Annual NIH Dollars Impacted
YRC Publications
New Research
We are developing technology to produce biosensors based on a ligand-binding domain (LBD) that may, in principle, be applied to any target molecule. The power of this method is illustrated in this paper by development of biosensors for digoxin and progesterone.
Read more in eLIFE or in PubMed Central.
In this work, we combine the results of protein cross-linking mass spectrometry with iterative structural modelling to determine the molecular architecture of the 10-member Dam1p protein complex in S. cerevisiae. Using this technique, we can model conformational changes resulting from binding with microtubules.
Read more in Nature Communications or in PubMed Central.
Latest Publications
Xie, Y et al. (2025) Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis. Cell Rep 44 (4):115439. PubMed PMID:40208794
Shen, H et al. (2025) De novo design of inducibly assembling multi-component filaments. bioRxiv :. PubMed PMID:40196579
Lavallée-Adam, M et al. (2025) TargetSeeker-MS: A Bayesian Inference Approach for Drug-Target Discovery Using Protein Fractionation Coupled to Mass Spectrometry. J Am Soc Mass Spectrom 36 (4):664-679. PubMed PMID:40067882
Riffle, M et al. (2025) Limelight: An Open, Web-Based Tool for Visualizing, Sharing, and Analyzing Mass Spectrometry Data from DDA Pipelines. J Proteome Res 24 (4):1895-1906. PubMed PMID:40036265
Zhang, J et al. (2025) Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling. bioRxiv :. PubMed PMID:39829937