Learn how to collaborate with the YRC–leveraging our technology and expertise in your research.
197
Active Projects
230
Collaborators Since 2011
$38M
Annual NIH Dollars Impacted
727
YRC Publications
New Research
We are developing technology to produce biosensors based on a ligand-binding domain (LBD) that may, in principle, be applied to any target molecule. The power of this method is illustrated in this paper by development of biosensors for digoxin and progesterone.
In this work, we combine the results of protein cross-linking mass spectrometry with iterative structural modelling to determine the molecular architecture of the 10-member Dam1p protein complex in S. cerevisiae. Using this technique, we can model conformational changes resulting from binding with microtubules.
Nguyen, TT et al. (2024) A tick saliva serpin, IxsS17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent. PLoS Pathog 20 (2):e1012032. PubMed PMID:38394332
da Silva Vaz Junior, I et al. (2024) Changes in saliva protein profile throughout Rhipicephalus microplus blood feeding. Parasit Vectors 17 (1):36. PubMed PMID:38281054
Martin, R et al. (2024) Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA. PLoS Genet 20 (1):e1010850. PubMed PMID:38175823
Cheng, LC et al. (2023) Comparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope. Life Sci Alliance 6 (9):. PubMed PMID:37433644
Song, R et al. (2023) Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Nat Commun 14 (1):3652. PubMed PMID:37339972