The YRC is a NIGMS Biomedical Technology Research Center based at the University of Washington in Seattle. Click to learn more about us.
Learn more about the technologies being developed by the YRC and how they are being applied to biomedical problems.
Learn how to collaborate with the YRC–leveraging our technology and expertise in your research.
Active Projects
Collaborators Since 2011
Annual NIH Dollars Impacted
YRC Publications
New Research
We are developing technology to produce biosensors based on a ligand-binding domain (LBD) that may, in principle, be applied to any target molecule. The power of this method is illustrated in this paper by development of biosensors for digoxin and progesterone.
Read more in eLIFE or in PubMed Central.
In this work, we combine the results of protein cross-linking mass spectrometry with iterative structural modelling to determine the molecular architecture of the 10-member Dam1p protein complex in S. cerevisiae. Using this technique, we can model conformational changes resulting from binding with microtubules.
Read more in Nature Communications or in PubMed Central.
Latest Publications
Zhao, X et al. (2022) The metabolome as a biomarker of aging in Drosophila melanogaster. Aging Cell :e13548. PubMed PMID:35019203
Marsh, AN et al. (2022) Skyline Batch: An Intuitive User Interface for Batch Processing with Skyline. J Proteome Res 21 (1):289-294. PubMed PMID:34919405
Cohen, ZR et al. (2021) Prebiotic Membranes and Micelles Do Not Inhibit Peptide Formation During Dehydration. Chembiochem :. PubMed PMID:34881485
Kirkwood, KI et al. (2022) Development and Application of Multidimensional Lipid Libraries to Investigate Lipidomic Dysregulation Related to Smoke Inhalation Injury Severity. J Proteome Res 21 (1):232-242. PubMed PMID:34874736
Baboo, S et al. (2021) DeGlyPHER: An Ultrasensitive Method for the Analysis of Viral Spike N-Glycoforms. Anal Chem 93 (40):13651-13657. PubMed PMID:34597027