Imaging Functional Amyloid

TEM image of FapC amyloid fibrils. More...

Benjamin Hall Building

Location of the computational branch of the Daggett Lab.

Photo credit goes to CollinsWoerman

Seattle Location

Located in UDistrict at the University of Washington. More...

Protein Folding and Unfolding

One of our major research areas involves exploring how proteins change shape, especially in the context of disease.

Amyloid and Diabetes

Histological images of transgenic mouse islets expressing hIAPP co-incubated without and with AP5. Blue represents the cell nuclei, green amyloid deposits, and red insulin.

The Cake Crew

Congratualtions to the Daggett Lab for winning the cake competition at the 2017 BIOE holiday party!

Bacterial Biofilms

Exploring amyloid formation and structure with a blend of experimental and computational methods.

W.H. Foege Building

Home of the experimetal branch of the Daggett Lab.

Photo by Mary Levin

News

7 Jul 2018

Dylan Shea, musician and molecular engineer of the Daggett Lab, spurred Elon Musk to state his commitment to supply houses in Flint, Michigan with clean water! More...

2017

Congratulations to Natasha Paranjapye who received a Mary Gates Research Scholarship for 2018!

2017

Congratulations to Timothy Bi who received a Washington Research Foundation Fellowship for 2017-2018!

2017

Congratulations to Cheng-Chieh Hsu (aka Steven) who received a Mary Gates Research Scholarships for 2017!

2017

Congratulations to Lauren Martini who received a Mary Gates Research Scholarship for 2018!

2017

Valerie Daggett was been inducted as a Fellow of the American Institute for Medical and Biological Engineering, 2017! More...

2016

Congratulations to Nathan Maris who received the Biochemistry Department's Research Excellence Award at the 2016 Graduation Ceremony!

Congratulations to Matt Childers who has been been renewed to continue as a predoctoral trainee on the Bioengineering Cardiovascular Training Grant!

We are putting the final touches on documentation and licensing paperwork so that we can release our molecular modeling package in lucem molecular mechanics! More...

2015

Congratulations to Clare Towse who received the 2015 UW Postdoc Mentor of the Year Award! See the department's article on Clare by pressing here.

2015

Congratulations to Alissa Bleem who received a 2015 NSF Graduate Research Fellowship!

2014

Our amyloid work is included in an article on Innovative Medicine: Researchers develop advanced treatments through cutting-edge science in the November Issue of the Alaska Airlines Magazine. More...

2014

FINALLY, experimental results backing our 2004 hypothesis that alpha-sheet structure is associated with toxicity during amyloidosis has just gone live in eLife! Get the paper here. See the UW announcement here.

We have released DIVE, our Data Intensive Visual Analytics software framework for accessing, streaming, interrogating, comparing, and visualizing big data. Get more information about downloading DIVE here.

Join the Lab!

Paper of the Month

Paper of the Month

De Novo Designed Alpha-Sheet Peptides Inhibit Functional Amyloid Formation of Streptococcus Mutans Biofilms

Natasha Paranjapye, Valerie Daggett Journal of Molecular Biology, Article in Press

Streptococcus mutans is a bacterial species that predominates in the oral microbiome. S. mutans binds to the tooth surface, metabolizes sugars and produces acid, leading to cavity formation. S. mutans can also cause infectious endocarditis. Recent evidence suggests that S. mutans biofilms contain amyloid fibrils. Amyloids are insoluble fibrillar protein aggregates, and bacteria use functional amyloids to improve robustness of their biofilms. While the functional amyloids in bacteria such as E. coli and S. aureus have been heavily investigated, little is known about the mechanism of S. mutans amyloid formation. More...