Daggett Research Group | Home
Quick Links
Valerie Daggett
Group Meetings
Courses
Available Positions and How to Apply
Lab Photos
Contact Information
Paper of the Month
The R46Q, R131Q and R154H Polymorphs of Human DNA Glycosylase/β-Lyase hOgg1 Severely Distort the Active Site and DNA Recognition Site but do not Cause Unfolding
Anderson P.C. and Daggett V.
JACS, In Press, 2009
Reactive oxygen species can cause widespread cellular damage, including base alterations and strand breaks in DNA. An array of DNA-repair enzymes constitutes an essential part of the line of defense that cells use against oxidative damage to the genome. More...
Goals: Realistic simulation of protein dynamics, unfolding/folding, and conformational transitions linked to disease.
Latest News
- The Daggett Group and other labs are working with Microsoft External Research to create a GrayWulf cluster optimized to analyze their Dynameomics data. Read more about the project in this report from Microsoft and on the msdn eScience blog.
- The Daggett Group was awarded 1.5 million hours on the National Energy Research Scientific Computing Center (NERSC) for 2009! This computer time supports the Dynameomics Project.
- Congratulations to Sara Calhoun who was awarded a Mary Gates Scholarship to work on docking and drug design this year! Congratulations are also in order for Michelle McCully who received an NDSEG Fellowship, a three-year graduate award, from the Department of Defense.
- The Dynameomics Project, which began running on the supercomputers at NERSC in 2005 with the goal of simulating the unfolding pathways of all known protein folds, was listed as a major accomplishment in Advanced Scientific Computing Research at Lawrence Berkeley National Lab.
- The group's recent paper, "The intrinsic conformational propensities of the 20 naturally occurring amino acids and reflection of these propensities in proteins" published in PNAS, was highlighted by both NewsRX and Pharmacy Choice.
- A Press Release from Microsoft highlighting the Daggett Group's application of the new SQL Server 2008 to their Dynameomics Database was picked up by The New York Times, Forbes, CNBC, and others.
 |
 |
 |
 |
 |