Benjamin Hall Building
Location of the computational branch of the Daggett Lab.
Protein Folding and Unfolding
One of our major research areas involves exploring how proteins change shape, especially in the context of disease.
Amyloid and Diabetes
Histological images of transgenic mouse islets expressing hIAPP co-incubated without and with AP5. Blue represents the cell nuclei, green amyloid deposits, and red insulin.
The Cake Crew
Congratualtions to the Daggett Lab for winning the cake competition at the 2017 BIOE holiday party!
Exploring amyloid formation and structure with a blend of experimental and computational methods.
W.H. Foege Building
Home of the experimetal branch of the Daggett Lab.
Dylan Shea, musician and molecular engineer of the Daggett Lab, spurred Elon Musk to state his commitment to supply houses in Flint, Michigan with clean water! More...
Congratulations to Natasha Paranjapye who received a Mary Gates Research Scholarship for 2018!
Congratulations to Timothy Bi who received a Washington Research Foundation Fellowship for 2017-2018!
Congratulations to Cheng-Chieh Hsu (aka Steven) who received a Mary Gates Research Scholarships for 2017!
Congratulations to Lauren Martini who received a Mary Gates Research Scholarship for 2018!
Valerie Daggett was been inducted as a Fellow of the American Institute for Medical and Biological Engineering, 2017! More...
Congratulations to Nathan Maris who received the Biochemistry Department's Research Excellence Award at the 2016 Graduation Ceremony!
Congratulations to Matt Childers who has been been renewed to continue as a predoctoral trainee on the Bioengineering Cardiovascular Training Grant!
We are putting the final touches on documentation and licensing paperwork so that we can release our molecular modeling package in lucem molecular mechanics! More...
Congratulations to Clare Towse who received the 2015 UW Postdoc Mentor of the Year Award! See the department's article on Clare by pressing here.
Congratulations to Alissa Bleem who received a 2015 NSF Graduate Research Fellowship!
Our amyloid work is included in an article on Innovative Medicine: Researchers develop advanced treatments through cutting-edge science in the November Issue of the Alaska Airlines Magazine. More...
We have released DIVE, our Data Intensive Visual Analytics software framework for accessing, streaming, interrogating, comparing, and visualizing big data. Get more information about downloading DIVE here.
Paper of the Month
De Novo Designed Alpha-Sheet Peptides Inhibit Functional Amyloid Formation of Streptococcus Mutans Biofilms
Natasha Paranjapye, Valerie Daggett Journal of Molecular Biology, Article in Press
Streptococcus mutans is a bacterial species that predominates in the oral microbiome. S. mutans binds to the tooth surface, metabolizes sugars and produces acid, leading to cavity formation. S. mutans can also cause infectious endocarditis. Recent evidence suggests that S. mutans biofilms contain amyloid fibrils. Amyloids are insoluble fibrillar protein aggregates, and bacteria use functional amyloids to improve robustness of their biofilms. While the functional amyloids in bacteria such as E. coli and S. aureus have been heavily investigated, little is known about the mechanism of S. mutans amyloid formation. More...