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University of Washington - College of Engineering - School of Medicine - Department of Bioengineering

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Valerie Daggett
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Paper of the Month

Principles of Ligand Binding within a Completely Buried Cavity in HIF2α PAS-B
Paper of the Month
Key J., Scheuermann T.H., Anderson P.C., Daggett V., and Gardner K.H.
JACS, In Press, 2009

Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors responsible for the metazoan hypoxia response and promote tumor growth, metastasis, and resistance to cancer treatment. The C-terminal Per-ARNT-Sim (PAS) domain of HIF2α (HIF2a PAS-B) contains a preformed solvent-inaccessible cavity that binds artificial ligands that allosterically perturb the formation of the HIF heterodimer. More...


Goals: Realistic simulation of protein dynamics, unfolding/folding, and conformational transitions linked to disease.

Prion Protein Protofibril Model

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