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Paper of the Month
GB1 Is Not a Two-State Folder: Identification and Characterization of an On-Pathway Intermediate
Morrone A., Giri R., Toofanny R.D., Travaglini-Allocatelli C., Brunori M., Daggett V., and Gianni S.
Biophys J 101: 2053-2060, 2011
The folding pathway of the small α/β protein GB1 has been extensively studied during the past two decades using both theoretical and experimental approaches. These studies provided a consensus view that the protein folds in a two-state manner. Here, we reassessed the folding of GB1, both by experiments and simulations, and detected the presence of an on-pathway intermediate. More...
Goals: Realistic simulation of protein dynamics, unfolding/folding, and conformational transitions linked to disease.
Latest News
- Undergrads interested in conducting research in the Daggett Lab over the summer will only be considered through established UW programs, such as the NNIN REU, Amgen Scholars Program, NASA Internships, and NSF Pathways to Science. Note that these programs have quickly approching deadlines.
- Undergraduate Robert Su received a prestigious Capstone Scholarship from the Department of Bioengineering as well as a Mary Gates Research Scholarship for his Capstone Project work on DIVE. DIVE is a piece of software currently under development in the Daggett Lab for visualizing large datasets. Congratulations, Robert!
- The group's work on urea denaturation was referenced in an article on protein unfolding published by the Royal Society of Chemistry.
- Valerie is honored to have been named a Biophysical Society Fellow for 2011 for her technical innovations and improvements in the field of molecular dynamics simulation.
- The Group is looking for a postdoctoral fellow interested in applying for the UW Sackler Scholars Program. The program offers a competitve two-year fellowship for work in two different labs at UW in the field of biophysics.
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