Diabetes News You Can Use
Bariatric surgery tied to reduced CV events in diabetes, study shows P
Patients with type 2 diabetes and obesity had a lower composite incidence of macrovascular events, including coronary artery and cerebrovascular events, five years after undergoing bariatric surgery, compared with those who received usual care, according to a study published in the Journal of the American Medical Association. Researchers analyzed data on 20,235 patients with severe obesity, mean age of 50.
Research shows efficacy of dual GIP, GLP-1 RA in diabetes
A study in The Lancet showed that 15% to 82% of type 2 diabetes patients treated with LY3298176, a dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist, achieved the A1C target of at least 6.5% at 26 weeks, compared with 39% of those on dulaglutide or 2% on placebo. Researchers conducted a double-blind randomized Phase II study involving 316 patients with diabetes, ages 18 to 75, and found the LY3298176 group also had greater changes in mean body weight and waist circumference than the control group.
Endocrinology Advisor (10/29)
Study links diabetes risk to fasting plasma glucose variability
A study in Diabetes Care showed a 24% increased risk for type 2 diabetes for every one standard deviation increase in fasting plasma glucose coefficient of variation. Researchers evaluated data from the Korean National Health Insurance System involving 131,744 people without diabetes at baseline and found that older males who completed little physical activity, had a higher incidence of dyslipidemia and hypertension, drank alcohol and smoked had greater variation of fasting plasma glucose levels.
Endocrinology Advisor (10/12)
Study: Type 2 diabetes alone may not contribute to mortality risk
A study in The New England Journal of Medicine showed that patients with type 2 diabetes who did not have any risk factors — smoking, albuminuria or abnormal A1C, blood pressure or LDL cholesterol — did not have excess mortality risk or increased risk for acute myocardial infarction or stroke, but they were at a higher risk for heart failure, compared with those who did not have diabetes. Researchers studied more than 270,000 Swedish registry patients with diabetes and found that smoking was the top predictor for mortality, while A1C above the target range was the strongest predictor for acute MI and stroke.
Only 29.9% of diabetes, CVD patients achieve all secondary prevention targets
Researchers analyzed data from the TECOS trial involving 13,616 adults with diabetes and cardiovascular disease from 38 countries and found that only 29.9% of patients met all five secondary prevention targets — blood pressure and lipid control, use of aspirin and prophylactic medications, and not smoking — compared with nearly three-quarters who met four of the targets. The findings, published in Circulation and presented at the Heart in Diabetes Clinical Education Conference, revealed that non-smoking status was the most often met target, while BP control was the target met least often.
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The Diabates and Metabolism Seminar Series will resume in the Fall.
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