Diabetes News You Can Use

Researchers examine effects of weight-loss surgery on diabetes, obese patients

A study in the Journal of the American Medical Association showed that 50% of type 2 diabetes patients with obesity who underwent weight-loss surgery reached targeted blood glucose, cholesterol and blood pressure levels related with diabetes control a year after the procedure, which dropped to 23% at five years; by comparison, 16% of those in the lifestyle intervention group experienced improved diabetes-related health issues after a year, which declined to 4% after five years. Another study in the same journal revealed that those who had weight-loss surgery had an up to 50% lower risk of dying than those who received usual care.

HealthDay News (1/16)    

Research links mutation to diabetes, insulin-producing tumors

The p.Ser64Phe mutation in the MAFA gene is likely associated with a type of non-insulin-dependent diabetes and multiple insulin-producing neuroendocrine tumors, according to a study in the Proceedings of the National Academy of Sciences. UK researchers studied the DNA of 39 adults from two families with diabetes and autosomal dominant insulinomatosis and nine people with sporadic insulinomatosis and found that “the p.Ser64Phe mutation not only significantly increased the stability of MAFA, whose levels were unaffected by variable glucose concentrations in [beta]-cell lines, but also enhanced its transactivation activity.”

Healio (free registration)/Endocrine Today (1/16)  

Research shows positive effects of GLP-1 RA on heart health in diabetes

Type 2 diabetes patients who received GLP-1 receptor agonists experienced a 10% reduction in their risk for a combination of stroke, heart attack or death from heart disease, a 13% reduction in heart disease mortality risk and a 12% reduced risk for all-cause mortality, compared with those on placebo, according to a study in The Lancet Diabetes & Endocrinology. UK researchers evaluated data from four trials and found no significant differences in terms of severe hypoglycemia, pancreatic cancer and pancreatitis between the groups.

Diabetes (UK) (12/14)    

Study examines prevalence of diabetes among US veterans

Researchers analyzed data from the National Health and Nutrition Examination Survey from 2005 to 2014 and found that the overall prevalence of diabetes and undiagnosed diabetes among US veterans was 20.5% and 3.4%, respectively, in 2013 to 2014. The findings in the CDC’s Preventing Chronic Disease revealed that diabetes prevalence increased from 15.5% in 2005 to 2006 to 20.5% in 2013 to 2014.

Physician’s Briefing/HealthDay News (12/14)  

CVD risk in diabetes tied to advanced glycation end products, oxidation products

A study in Diabetes Care showed that higher levels of certain advanced glycation end products and lower levels of the oxidation product methionine sulfoxide were associated with an increased risk for cardiovascular disease among adults with type 2 diabetes. Researchers used a cohort of 716 patients with and without diabetes from the Veterans Affairs Diabetes Trial and the ACCORD study and found that those with prior CVD had higher carboxymethyl lysine, glyoxal hydroimidazolone and 3-deoxyglucosone hydroimidazolone, compared with those without prior CVD.

Healio (free registration)/Endocrine Today (12/14)  

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