The RISE Consortium continues to publish its findings from three parallel protocols in adults and youth with impaired glucose tolerance or recently diagnosed type 2 diabetes. The Diabetes Research Center played an important role in helping recruit for this seven center study. Three manuscripts were recently published in Diabetes Care on baseline predictors of worsening glycemia and alpha-cell function at baseline and in response to the interventions, the latter highlighting the impact of weight loss on glucagon responses. These three manuscripts and an editorial appear as an online compendium.