Carla Greenbaum


Benaroya Research Institute

Clinical Research


Research Interest: Clinical Trials and Large-Scale Epidemiologic Studies, Etiology, Pathogenesis and Treatment of Type 1 Diabetes

DRC Publications

Mauseth, R; Lord, SM; Hirsch, IB; Kircher, RC; Matheson, DP; Greenbaum, CJ ; Stress Testing of an Artificial Pancreas System With Pizza and Exercise Leads to Improvements in the System's Fuzzy Logic Controller J Diabetes Sci Technol 9 6: 1253-9; 2015 PMC4667297

Sosenko, JM; Skyler, JS; DiMeglio, LA; Beam, CA; Krischer, JP; Greenbaum, CJ; Boulware, D; Rafkin, LE; Matheson, D; ... Type 1 Diabetes TrialNet and Diabetes Prevention Trial_Type 1 Study Groups A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history Diabetes Care 38 2: 271-6; 2015 PMC4302258

Hao, W; Greenbaum, CJ; Krischer, JP; Cuthbertson, D; Marks, JB; Palmer, JP ; The Effect of DPT-1 intravenous insulin infusion and daily subcutaneous insulin on endogenous insulin secretion and postprandial glucose tolerance Diabetes Care 38 5: 891-6; 2015 PMC4407749

Lord, S; Greenbaum, CJ ; Disease modifying therapies in type 1 diabetes: Where have we been, and where are we going? Pharmacol Res 98 3-8; 2015 PMC4469522

Sosenko, JM; Skyler, JS; Beam, CA; Boulware, D; Mahon, JL; Krischer, JP; Greenbaum, CJ; Rafkin, LE; Matheson, D; ... Type 1 Diabetes TrialNet and Diabetes Prevention Trial_Type 1 Study Groups The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months Diabetes Care 38 5: 940-2; 2015 PMC4407750

Afkarian, M; Hirsch, IB; Tuttle, KR; Greenbaum, C; Himmelfarb, J; de Boer, IH ; Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease Physiol Rep 2 5: e12010; 2014 PMC4098738

McGinty, JW; Chow, IT; Greenbaum, C; Odegard, J; Kwok, WW; James, EA ; Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes Diabetes 63 9: 3033-40; 2014 PMC4392921

Chen, YG; Cabrera, SM; Jia, S; Kaldunski, ML; Kramer, J; Cheong, S; Geoffrey, R; Roethle, MF; Woodliff, JE; ... Hessner, MJ Molecular signatures differentiate immune states in type 1 diabetic families Diabetes 63 11: 3960-73; 2014 PMC4207392

Pescovitz, MD; Greenbaum, CJ; Bundy, B; Becker, DJ; Gitelman, SE; Goland, R; Gottlieb, PA; Marks, JB; Moran, A; ... Type 1 Diabetes TrialNet Anti-CD20 Study Group B-lymphocyte depletion with rituximab and beta-cell function: two-year results Diabetes Care 37 2: 453-9; 2014 PMC3898764

Durinovic-Bello, I; Gersuk, VH; Ni, C; Wu, R; Thorpe, J; Jospe, N; Sanda, S; Greenbaum, CJ; Nepom, GT ; ... Nepom, GT Avidity-dependent programming of autoreactive T cells in T1D PLoS One 9 5: e98074; 2014 PMC4028311

Yang, J; Chow, IT; Sosinowski, T; Torres-Chinn, N; Greenbaum, CJ; James, EA; Kappler, JW; Davidson, HW; Kwok, WW ; ... Kwok, WW Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes Proc Natl Acad Sci U S A 111 41: 14840-5; 2014 PMC4205657

Chow, IT; Yang, J; Gates, TJ; James, EA; Mai, DT; Greenbaum, C; Kwok, WW ; Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development PLoS One 9 11: e112882; 2014 PMC4236121

Mauseth, R; Hirsch, IB; Bollyky, J; Kircher, R; Matheson, D; Sanda, S; Greenbaum, C ; Use of a "fuzzy logic" controller in a closed-loop artificial pancreas Diabetes Technol Ther 15 8: 628-33; 2013

Herold, KC; Gitelman, SE; Ehlers, MR; Gottlieb, PA; Greenbaum, CJ; Hagopian, W; Boyle, KD; Keyes-Elstein, L; Aggarwal, S; ... AbATE Study Team Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders Diabetes 62 11: 3766-74; 2013 PMC3806618

Rigby, MR; DiMeglio, LA; Rendell, MS; Felner, EI; Dostou, JM; Gitelman, SE; Patel, CM; Griffin, KJ; Tsalikian, E; ... T1DAL Study Team Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL Study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial Lancet Diabetes Endocrinol 1 4: 284-94; 2013 PMC3957186

Sanda, S; Wei, S; Rue, T; Shilling, H; Greenbaum, C ; A SNP in G6PC2 predicts insulin secretion in type 1 diabetes Acta Diabetol 50 3: 459-62; 2013

Greenbaum, CJ; Beam, CA; Type 1 Diabetes TrialNet Study Group ; Response to Comment on: Greenbaum et al. Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite type 1 diabetes TrialNet data. Diabetes 2012;61:2066-2073 Diabetes 62 6: e8; 2013 PMC3661623

Pihoker, C; Gilliam, LK; Ellard, S; Dabelea, D; Davis, C; Dolan, LM; Greenbaum, CJ; Imperatore, G; Lawrence, JM; ... SEARCH for Diabetes in Youth Study Group Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth J Clin Endocrinol Metab 98 10: 4055-62; 2013 PMC3790621

Moran, A; Bundy, B; Becker, DJ; DiMeglio, LA; Gitelman, SE; Goland, R; Greenbaum, CJ; Herold, KC; Marks, JB; ... AIDA Study Group Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials Lancet 381 9881: 1905-15; 2013 PMC3827771

Crume, TL; Andrews, JS; D'Agostino, RB, Jr.; Pettitt, DJ; Mayer-Davis, EJ; Law, JR; Dolan, L; Lawrence, JM; Saydah, S; ... SEARCH for Diabetes in Youth Study Group The influence of exposure to maternal diabetes in utero on the rate of decline in beta-cell function among youth with diabetes J Pediatr Endocrinol Metab 26 7-8: 721-7; 2013 PMC4074015

Long, SA; Buckner, JH; Greenbaum, CJ ; IL-2 therapy in type 1 diabetes: "Trials" and tribulations Clin Immunol 149 3: 324-31; 2013

Bollyky, JB; Long, SA; Fitch, M; Bollyky, PL; Rieck, M; Rogers, R; Samuels, PL; Sanda, S; Buckner, JH; ... Greenbaum, CJ Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes Clin Exp Immunol 172 3: 363-74; 2013 PMC3646435

Yang, J; James, EA; Sanda, S; Greenbaum, C; Kwok, WW ; CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring Immunology 138 3: 269-79; 2013 PMC3573280

Sosenko, JM; Skyler, JS; Beam, CA; Krischer, JP; Greenbaum, CJ; Mahon, J; Rafkin, LE; Matheson, D; Herold, KC; ... Type 1 Diabetes TrialNet and Diabetes Prevention Trial_Type 1 Study Groups Acceleration of the loss of the first-phase insulin response during the progression to Type 1 Diabetes TrialNet and Diabetes Prevention Trial_Type 1 participants Diabetes 62 12: 4179-83; 2013 PMC3837047

Yu, L; Boulware, DC; Beam, CA; Hutton, JC; Wenzlau, JM; Greenbaum, CJ; Bingley, PJ; Krischer, JP; Sosenko, JM; ... Type 1 Diabetes TrialNet Study, G Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies Diabetes Care 35 6: 1213-8; 2012 PMC3357246

Greenbaum, CJ; Schatz, DA; Haller, MJ; Sanda, S ; Through the fog: recent clinical trials to preserve beta-cell function in type 1 diabetes Diabetes 61 6: 1323-30; 2012 PMC3357268

Long, SA; Rieck, M; Sanda, S; Bollyky, JB; Samuels, PL; Goland, R; Ahmann, A; Rabinovitch, A; Aggarwal, S; ... Diabetes TrialNet the Immune Tolerance Network Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function Diabetes 61 9: 2340-8; 2012 PMC3425404

Greenbaum, C ; Perspective: Rethink the immune connection Nature 485 7398: S9; 2012

Greenbaum, CJ; Beam, CA; Boulware, D; Gitelman, SE; Gottlieb, PA; Herold, KC; Lachin, JM; McGee, P; Palmer, JP; ... Type 1 Diabetes TrialNet Study Group Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data Diabetes 61 8: 2066-73; 2012 PMC3402330

Greenbaum, CJ ; Dead or alive? Diabetes Care 35 3: 459-60; 2012 PMC3322728

Dabelea, D; Mayer-Davis, EJ; Andrews, JS; Dolan, LM; Pihoker, C; Hamman, RF; Greenbaum, C; Marcovina, S; Fujimoto, W; ... D'Agostino, R, Jr. Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth Study Diabetologia 55 12: 3359-68; 2012 PMC4492685

Sosenko, JM; Skyler, JS; Mahon, J; Krischer, JP; Beam, CA; Boulware, DC; Greenbaum, CJ; Rafkin, LE; Cowie, C; ... Diabetes Prevention Trial-Type 1 Study Group The application of the Diabetes Prevention Trial-Type 1 risk score for identifying a preclinical state of type 1 diabetes Diabetes Care 35 7: 1552-5; 2012 PMC3379597

Habib, T; Funk, A; Rieck, M; Brahmandam, A; Dai, X; Panigrahi, AK; Luning Prak, ET; Meyer-Bahlburg, A; Sanda, S; ... Buckner, JH Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant J Immunol 188 1: 487-96; 2012 PMC3670766