Gregory Morton

Research Professor

South Lake Union



Research Interest: Etiology, Pathogenesis and Treatment of Type 1 Diabetes

DRC Publications

Meek, TH; Morton, GJ ; The role of leptin in diabetes: metabolic effects Diabetologia 59 5: 928-32; 2016

Meek, TH; Nelson, JT; Matsen, ME; Dorfman, MD; Guyenet, SJ; Damian, V; Allison, MB; Scarlett, JM; Nguyen, HT; ... Morton, GJ Functional identification of a neurocircuit regulating blood glucose Proc Natl Acad Sci U S A 113 14: E2073-82; 2016 PMC4833243

Blevins, JE; Thompson, BW; Anekonda, VT; Ho, JM; Graham, JL; Roberts, ZS; Hwang, BH; Ogimoto, K; Wolden-Hanson, T; ... Baskin, DG Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization Am J Physiol Regul Integr Comp Physiol 310 7: R640-58; 2016 PMC4867381

Scarlett, JM; Rojas, JM; Matsen, ME; Kaiyala, KJ; Stefanovski, D; Bergman, RN; Nguyen, HT; Dorfman, MD; Lantier, L; ... Schwartz, MW Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents Nat Med 22 7: 800-6; 2016 PMC4938755

Kaiyala, KJ; Ogimoto, K; Nelson, JT; Schwartz, MW; Morton, GJ ; Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions PLoS One 10 3: e0119391; 2015 PMC4355297

Chen, J; Kaiyala, KJ; Lam, J; Agrawal, N; Nguyen, L; Ogimoto, K; Spencer, D; Morton, GJ; Schwartz, MW; ... Dichek, HL In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl-/-) mice Physiol Rep 3 4: 2015 PMC4425970

Rubinow, KB; Wang, S; den Hartigh, LJ; Subramanian, S; Morton, GJ; Buaas, FW; Lamont, D; Gray, N; Braun, RE; ... Page, ST Hematopoietic androgen receptor deficiency promotes visceral fat deposition in male mice without impairing glucose homeostasis Andrology 3 4: 787-96; 2015 PMC4736737

Rojas, JM; Matsen, ME; Mundinger, TO; Morton, GJ; Stefanovski, D; Bergman, RN; Kaiyala, KJ; Taborsky, GJ, Jr.; Schwartz, MW ; ... Schwartz, MW Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response Mol Metab 4 8: 561-8; 2015 PMC4529498

Meek, TH; Dorfman, MD; Matsen, ME; Fischer, JD; Cubelo, A; Kumar, MR; Taborsky, GJ, Jr.; Morton, GJ ; Evidence that in uncontrolled diabetes, hyperglucagonemia is required for ketosis but not for increased hepatic glucose production or hyperglycemia Diabetes 64 7: 2376-87; 2015 PMC4477352

Blevins, JE; Graham, JL; Morton, GJ; Bales, KL; Schwartz, MW; Baskin, DG; Havel, PJ ; Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys Am J Physiol Regul Integr Comp Physiol 308 5: R431-8; 2015 PMC4346756

Meek, TH; Matsen, ME; Damian, V; Cubelo, A; Chua, SC, Jr.; Morton, GJ ; Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes Endocrinology 155 11: 4157-67; 2014 PMC4197991

Morton, GJ; Meek, TH; Schwartz, MW ; Neurobiology of food intake in health and disease Nat Rev Neurosci 15 6: 367-78; 2014 PMC4076116

Ho, JM; Anekonda, VT; Thompson, BW; Zhu, M; Curry, RW; Hwang, BH; Morton, GJ; Schwartz, MW; Baskin, DG; ... Blevins, JE Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats Endocrinology 155 8: 2845-57; 2014 PMC4098005

Spiezio, SH; Amon, LM; McMillen, TS; Vick, CM; Houston, BA; Caldwell, M; Ogimoto, K; Morton, GJ; Kirk, EA; ... LeBoeuf, RC Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice Mamm Genome 25 11-12: 549-63; 2014 PMC4241139

Morton, GJ; Kaiyala, KJ; Foster-Schubert, KE; Cummings, DE; Schwartz, MW ; Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans J Clin Endocrinol Metab 99 2: E241-5; 2014 PMC3913810

Guyenet, SJ; Matsen, ME; Morton, GJ; Kaiyala, KJ; Schwartz, MW ; Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food Mol Metab 2 2: 116-22; 2013 PMC3817387

Nix, MA; Kaelin, CB; Ta, T; Weis, A; Morton, GJ; Barsh, GS; Millhauser, GL ; Molecular and functional analysis of human beta-defensin 3 action at melanocortin receptors Chem Biol 20 6: 784-95; 2013 PMC3714013

Meek, TH; Matsen, ME; Dorfman, MD; Guyenet, SJ; Damian, V; Nguyen, HT; Taborsky, GJ, Jr.; Morton, GJ ; Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia Endocrinology 154 9: 3067-76; 2013 PMC3749482

Matsen, ME; Thaler, JP; Wisse, BE; Guyenet, SJ; Meek, TH; Ogimoto, K; Cubelo, A; Fischer, JD; Kaiyala, KJ; ... Morton, GJ In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue Am J Physiol Endocrinol Metab 304 7: E734-46; 2013 PMC3625754

Morton, GJ; Matsen, ME; Bracy, DP; Meek, TH; Nguyen, HT; Stefanovski, D; Bergman, RN; Wasserman, DH; Schwartz, MW ; ... Schwartz, MW FGF19 action in the brain induces insulin-independent glucose lowering J Clin Invest 123 11: 4799-808; 2013 PMC3809800

Schwartz, MW; Seeley, RJ; Tschop, MH; Woods, SC; Morton, GJ; Myers, MG; D'Alessio, D ; Cooperation between brain and islet in glucose homeostasis and diabetes Nature 503 7474: 59-66; 2013 PMC3983910

Meek, TH; Wisse, BE; Thaler, JP; Guyenet, SJ; Matsen, ME; Fischer, JD; Taborsky, GJ, Jr.; Schwartz, MW; Morton, GJ ; ... Morton, GJ BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production Diabetes 62 5: 1512-8; 2013 PMC3636618

Roth, CL; Elfers, CT; Figlewicz, DP; Melhorn, SJ; Morton, GJ; Hoofnagle, A; Yeh, MM; Nelson, JE; Kowdley, KV ; ... Kowdley, KV Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation Hepatology 55 4: 1103-11; 2012

Morton, GJ; Thatcher, BS; Reidelberger, RD; Ogimoto, K; Wolden-Hanson, T; Baskin, DG; Schwartz, MW; Blevins, JE ; Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats Am J Physiol Endocrinol Metab 302 1: E134-44; 2012 PMC3328087

Thaler, JP; Yi, CX; Schur, EA; Guyenet, SJ; Hwang, BH; Dietrich, MO; Zhao, X; Sarruf, DA; Izgur, V; ... Schwartz, MW Obesity is associated with hypothalamic injury in rodents and humans J Clin Invest 122 1: 153-62; 2012 PMC3248304

Meek, TH; Morton, GJ ; Leptin, diabetes, and the brain Indian J Endocrinol Metab 16 Suppl 3: S534-42; 2012 PMC3602981

Kaiyala, KJ; Morton, GJ; Thaler, JP; Meek, TH; Tylee, T; Ogimoto, K; Wisse, BE ; Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice PLoS One 7 8: e41473; 2012 PMC3425585