Jane Buckner

Affiliate Professor

Benaroya Research Institute


Email: jbuckner@u.washington.edu

Research Interest: Clinical Trials and Large-Scale Epidemiologic Studies, Etiology, Pathogenesis and Treatment of Type 1 Diabetes

DRC Publications

Buckner, JH; Nepom, GT ; Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes J Autoimmun 71 44-50; 2016 PMC4903876

Rawlings, DJ; Dai, X; Buckner, JH ; The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human J Immunol 194 7: 2977-84; 2015 PMC4369788

Mikacenic, C; Schneider, A; Radella, F; Buckner, JH; Wurfel, MM ; Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression J Immunol 193 12: 5786-90; 2014 PMC4258445

Long, A; Buckner, JH ; Intersection between genetic polymorphisms and immune deviation in type 1 diabetes Curr Opin Endocrinol Diabetes Obes 20 4: 285-91; 2013

Subramanian, S; Turner, MS; Ding, Y; Goodspeed, L; Wang, S; Buckner, JH; O'Brien, K; Getz, GS; Reardon, CA; ... Chait, A Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice J Lipid Res 54 10: 2831-41; 2013 PMC3770095

Long, SA; Buckner, JH; Greenbaum, CJ ; IL-2 therapy in type 1 diabetes: "Trials" and tribulations Clin Immunol 149 3: 324-31; 2013

Bollyky, JB; Long, SA; Fitch, M; Bollyky, PL; Rieck, M; Rogers, R; Samuels, PL; Sanda, S; Buckner, JH; ... Greenbaum, CJ Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes Clin Exp Immunol 172 3: 363-74; 2013 PMC3646435

Dai, X; James, RG; Habib, T; Singh, S; Jackson, S; Khim, S; Moon, RT; Liggitt, D; Wolf-Yadlin, A; ... Rawlings, DJ A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models J Clin Invest 123 5: 2024-36; 2013 PMC3638909

Huang, C; Martin, S; Pfleger, C; Du, J; Buckner, JH; Bluestone, JA; Riley, JL; Ziegler, SF ; Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28 J Immunol 190 9: 4470-3; 2013 PMC4197931

Long, SA; Rieck, M; Sanda, S; Bollyky, JB; Samuels, PL; Goland, R; Ahmann, A; Rabinovitch, A; Aggarwal, S; ... Diabetes TrialNet the Immune Tolerance Network Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function Diabetes 61 9: 2340-8; 2012 PMC3425404

Cerosaletti, K; Buckner, JH ; Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22 Rev Diabet Stud 9 4: 188-200; 2012 PMC3740690

Stone, B; Rieck, M; Rawlings, CA; Kas, A; Shendure, J; Jones, H; Buckner, JH ; Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cells Clin Immunol 145 2: 153-60; 2012

Nepom, GT; Buckner, JH ; A functional framework for interpretation of genetic associations in T1D Curr Opin Immunol 24 5: 516-21; 2012 PMC4260931

Habib, T; Funk, A; Rieck, M; Brahmandam, A; Dai, X; Panigrahi, AK; Luning Prak, ET; Meyer-Bahlburg, A; Sanda, S; ... Buckner, JH Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant J Immunol 188 1: 487-96; 2012 PMC3670766