Sakeneh Zraika

Research Associate Professor

VA Puget Sound Health Care System



Research Interest: Pathophysiology and Treatment of Type 2 Diabetes

DRC Publications

Meier, DT; Entrup, L; Templin, AT; Hogan, MF; Mellati, M; Zraika, S; Hull, RL; Kahn, SE ; The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets Diabetologia 59 10: 2166-71; 2016 PMC5026922

Hogan, MF; Meier, DT; Zraika, S; Templin, AT; Mellati, M; Hull, RL; Leissring, MA; Kahn, SE ; Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition In Vitro Endocrinology en20161410; 2016

Meier, DT; Tu, LH; Zraika, S; Hogan, MF; Templin, AT; Hull, RL; Raleigh, DP; Kahn, SE ; Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity J Biol Chem 290 51: 30475-85; 2015 PMC4683269

Meier, DT; Entrup, L; Templin, AT; Hogan, MF; Samarasekera, T; Zraika, S; Boyko, EJ; Kahn, SE ; Determination of optimal sample size for quantification of beta-cell area, amyloid area and beta-cell apoptosis in isolated islets J Histochem Cytochem 63 8: 663-73; 2015 PMC4530400

Meier, DT; Morcos, M; Samarasekera, T; Zraika, S; Hull, RL; Kahn, SE ; Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice Diabetologia 57 9: 1884-8; 2014 PMC4267509

Udayasankar, J; Zraika, S; Aston-Mourney, K; Subramanian, SL; Brooks-Worrell, BM; Taborsky, GJ; Hull, RL ; Rosiglitazone treatment does not decrease amyloid deposition in transplanted islets from transgenic mice expressing human islet amyloid polypeptide Transplant Proc 45 2: 574-9; 2013 PMC3602214

Aston-Mourney, K; Subramanian, SL; Zraika, S; Samarasekera, T; Meier, DT; Goldstein, LC; Hull, RL ; One year of sitagliptin treatment protects against islet amyloid-associated beta-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice Am J Physiol Endocrinol Metab 305 4: E475-84; 2013 PMC3891222

Zraika, S; Koh, DS; Barrow, BM; Lu, B; Kahn, SE; Andrikopoulos, S ; Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx Diabetes 62 5: 1593-601; 2013 PMC3636612

Aston-Mourney, K; Zraika, S; Udayasankar, J; Subramanian, SL; Green, PS; Kahn, SE; Hull, RL ; Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide J Biol Chem 288 5: 3553-9; 2013 PMC3561574

Subramanian, SL; Hull, RL; Zraika, S; Aston-Mourney, K; Udayasankar, J; Kahn, SE ; cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets Diabetologia 55 1: 166-74; 2012 PMC3249975

Aston-Mourney, K; Hull, RL; Zraika, S; Udayasankar, J; Subramanian, SL; Kahn, SE ; Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets Diabetologia 54 7: 1756-65; 2011 PMC3220951