DRC Publications
Meier, DT; Entrup, L; Templin, AT; Hogan, MF; Mellati, M; Zraika, S; Hull, RL; Kahn, SE ; The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets Diabetologia 59 10: 2166-71; 2016 PMC5026922
Hivert, MF; Christophi, CA; Franks, PW; Jablonski, KA; Ehrmann, DA; Kahn, SE; Horton, ES; Pollin, TI; Mather, KJ; ... Diabetes Prevention Program Research Group Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants Diabetes 65 2: 520-6; 2016 PMC4747453
Hogan, MF; Meier, DT; Zraika, S; Templin, AT; Mellati, M; Hull, RL; Leissring, MA; Kahn, SE ; Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition In Vitro Endocrinology en20161410; 2016
Hwang, YC; Fujimoto, WY; Hayashi, T; Kahn, SE; Leonetti, DL; Boyko, EJ ; Increased Visceral Adipose Tissue Is an Independent Predictor for Future Development of Atherogenic Dyslipidemia J Clin Endocrinol Metab 101 2: 678-85; 2016 PMC4880131
de Boer, IH; Zelnick, L; Afkarian, M; Ayers, E; Curtin, L; Himmelfarb, J; Ikizler, TA; Kahn, SE; Kestenbaum, B; ... Utzschneider, K Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD J Am Soc Nephrol 2016
Hwang, YC; Hayashi, T; Fujimoto, WY; Kahn, SE; Leonetti, DL; McNeely, MJ; Boyko, EJ ; Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype Int J Obes (Lond) 39 9: 1365-70; 2015 PMC4564328
Nolan, CJ; Ruderman, NB; Kahn, SE; Pedersen, O; Prentki, M ; Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673-686 Diabetes 64 10: e38-9; 2015
Araneta, MR; Kanaya, AM; Hsu, WC; Chang, HK; Grandinetti, A; Boyko, EJ; Hayashi, T; Kahn, SE; Leonetti, DL; ... Fujimoto, WY Optimum BMI cut points to screen asian americans for type 2 diabetes Diabetes Care 38 5: 814-20; 2015 PMC4407753
Kahn, SE; Buse, JB ; Medications for type 2 diabetes: how will we be treating patients in 50 years? Diabetologia 58 8: 1735-9; 2015 PMC4499484
Meier, DT; Tu, LH; Zraika, S; Hogan, MF; Templin, AT; Hull, RL; Raleigh, DP; Kahn, SE ; Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity J Biol Chem 290 51: 30475-85; 2015 PMC4683269
Nolan, CJ; Ruderman, NB; Kahn, SE; Pedersen, O; Prentki, M ; Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes Diabetes 64 3: 673-86; 2015 PMC4338588
Hogan, MF; Ravnskjaer, K; Matsumura, S; Huising, MO; Hull, RL; Kahn, SE; Montminy, M ; Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2 J Biol Chem 290 43: 25997-6006; 2015 PMC4646253
Diabetes Prevention Program Research Group; Hamman, RF; Horton, E; Barrett-Connor, E; Bray, GA; Christophi, CA; Crandall, J; Florez, JC; Fowler, S; ... Venditti, E Factors affecting the decline in incidence of diabetes in the Diabetes Prevention Program Outcomes Study (DPPOS) Diabetes 64 3: 989-98; 2015 PMC4338587
Goedecke, JH; Keswell, D; Weinreich, C; Fan, J; Hauksson, J; Victor, H; Utzschneider, K; Levitt, NS; Lambert, EV; ... Olsson, T Ethnic differences in hepatic and systemic insulin sensitivity and their associated determinants in obese black and white South African women Diabetologia 58 11: 2647-52; 2015 PMC4668114
Hwang, YC; Hayashi, T; Fujimoto, WY; Kahn, SE; Leonetti, DL; McNeely, MJ; Boyko, EJ ; Differential Association Between HDL Subclasses and the Development of Type 2 Diabetes in a Prospective Study of Japanese Americans Diabetes Care 38 11: 2100-5; 2015 PMC4613920
Meier, DT; Entrup, L; Templin, AT; Hogan, MF; Samarasekera, T; Zraika, S; Boyko, EJ; Kahn, SE ; Determination of optimal sample size for quantification of beta-cell area, amyloid area and beta-cell apoptosis in isolated islets J Histochem Cytochem 63 8: 663-73; 2015 PMC4530400
Marx, N; Rosenstock, J; Kahn, SE; Zinman, B; Kastelein, JJ; Lachin, JM; Espeland, MA; Bluhmki, E; Mattheus, M; ... Woerle, HJ Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA(R)) Diab Vasc Dis Res 12 3: 164-74; 2015 PMC4390606
Sullivan, CA; Kahn, SE; Fujimoto, WY; Hayashi, T; Leonetti, DL; Boyko, EJ ; Change in intra-abdominal fat predicts the risk of hypertension in Japanese Americans Hypertension 66 1: 134-40; 2015 PMC4467450
Phillips, LS; Ratner, RE; Buse, JB; Kahn, SE ; We can change the natural history of type 2 diabetes Diabetes Care 37 10: 2668-76; 2014 PMC4170125
Utzschneider, KM; Largajolli, A; Bertoldo, A; Marcovina, S; Nelson, JE; Yeh, MM; Kowdley, KV; Kahn, SE ; Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Beta-cell function in non-diabetic men and women J Diabetes Complications 28 2: 177-84; 2014 PMC3943487
Gujral, UP; Narayan, KM; Kahn, SE; Kanaya, AM ; The relative associations of beta-cell function and insulin sensitivity with glycemic status and incident glycemic progression in migrant Asian Indians in the United States: the MASALA study J Diabetes Complications 28 1: 45-50; 2014 PMC3877179
Kahn, SE; Cooper, ME; Del Prato, S ; Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future Lancet 383 9922: 1068-83; 2014 PMC4226760
Lipkin, EW; Schwartz, AV; Anderson, AM; Davis, C; Johnson, KC; Gregg, EW; Bray, GA; Berkowitz, R; Peters, AL; ... Look AHEAD Research Group The Look AHEAD Trial: bone loss at 4-year follow-up in type 2 diabetes Diabetes Care 37 10: 2822-9; 2014 PMC4170123
Meier, DT; Morcos, M; Samarasekera, T; Zraika, S; Hull, RL; Kahn, SE ; Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice Diabetologia 57 9: 1884-8; 2014 PMC4267509
Billings, LK; Jablonski, KA; Ackerman, RJ; Taylor, A; Fanelli, RR; McAteer, JB; Guiducci, C; Delahanty, LM; Dabelea, D; ... Diabetes Prevention Program Research Group-Rockville The influence of rare genetic variation in SLC30A8 on diabetes incidence and beta-cell function J Clin Endocrinol Metab 99 5: E926-30; 2014 PMC4010688
Rubin, RR; Wadden, TA; Bahnson, JL; Blackburn, GL; Brancati, FL; Bray, GA; Coday, M; Crow, SJ; Curtis, JM; ... Look AHEAD Research Group Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial Diabetes Care 37 6: 1544-53; 2014 PMC4030096
Espeland, MA; Glick, HA; Bertoni, A; Brancati, FL; Bray, GA; Clark, JM; Curtis, JM; Egan, C; Evans, M; ... Look AHEAD Research Group Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes Diabetes Care 37 9: 2548-56; 2014 PMC4140155
Delahanty, LM; Pan, Q; Jablonski, KA; Aroda, VR; Watson, KE; Bray, GA; Kahn, SE; Florez, JC; Perreault, L; ... Diabetes Prevention Program Research Group Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program Diabetes Care 37 10: 2738-45; 2014 PMC4170126
Dabelea, D; Ma, Y; Knowler, WC; Marcovina, S; Saudek, CD; Arakaki, R; White, NH; Kahn, SE; Orchard, TJ; ... Diabetes Prevention Program Research Group Diabetes autoantibodies do not predict progression to diabetes in adults: the Diabetes Prevention Program Diabet Med 31 9: 1064-8; 2014 PMC4138247
Pan, Q; Delahanty, LM; Jablonski, KA; Knowler, WC; Kahn, SE; Florez, JC; Franks, PW; Diabetes Prevention Program Research Group ; Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the Diabetes Prevention Program Obesity (Silver Spring) 21 9: E520-6; 2013 PMC4023472
Nathan, DM; Buse, JB; Kahn, SE; Krause-Steinrauf, H; Larkin, ME; Staten, M; Wexler, D; Lachin, JM; GRADE Study Research Group ; ... GRADE Study Research Group Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE) Diabetes Care 36 8: 2254-61; 2013 PMC3714493
Hayashi, T; Boyko, EJ; Sato, KK; McNeely, MJ; Leonetti, DL; Kahn, SE; Fujimoto, WY ; Patterns of insulin concentration during the OGTT predict the risk of type 2 diabetes in Japanese Americans Diabetes Care 36 5: 1229-35; 2013 PMC3631850
de Boer, IH; Sachs, M; Hoofnagle, AN; Utzschneider, KM; Kahn, SE; Kestenbaum, B; Himmelfarb, J ; Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease Kidney Int 83 2: 323-30; 2013 PMC3509239
Zraika, S; Koh, DS; Barrow, BM; Lu, B; Kahn, SE; Andrikopoulos, S ; Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx Diabetes 62 5: 1593-601; 2013 PMC3636612
Aston-Mourney, K; Zraika, S; Udayasankar, J; Subramanian, SL; Green, PS; Kahn, SE; Hull, RL ; Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide J Biol Chem 288 5: 3553-9; 2013 PMC3561574
Pomeroy, J; Renstrom, F; Gradmark, AM; Mogren, I; Persson, M; Bluck, L; Wright, A; Kahn, SE; Domellof, M; ... Franks, PW Maternal physical activity and insulin action in pregnancy and their relationships with infant body composition Diabetes Care 36 2: 267-9; 2013 PMC3554315
Faulenbach, MV; Wright, LA; Lorenzo, C; Utzschneider, KM; Goedecke, JH; Fujimoto, WY; Boyko, EJ; McNeely, MJ; Leonetti, DL; ... American Diabetes Association, GSG Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index J Diabetes Complications 27 2: 158-61; 2013 PMC3618472
Faulenbach, MV; Wright, LA; Lorenzo, C; Utzschneider, KM; Goedecke, JH; Fujimoto, WY; Boyko, EJ; McNeely, MJ; Leonetti, DL; ... American Diabetes Association Gennid Study Group Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index J Diabetes Complications 27 2: 158-61; 2013 PMC3618472
McCaffery, JM; Papandonatos, GD; Huggins, GS; Peter, I; Erar, B; Kahn, SE; Knowler, WC; Lipkin, EW; Kitabchi, AE; ... Look AHEAD Research Group Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial Hum Hered 75 2-4: 160-74; 2013 PMC4257841
Crane, PK; Walker, R; Hubbard, RA; Li, G; Nathan, DM; Zheng, H; Haneuse, S; Craft, S; Montine, TJ; ... Larson, EB Glucose levels and risk of dementia N Engl J Med 369 6: 540-8; 2013 PMC3955123
McCaffery, JM; Papandonatos, GD; Huggins, GS; Peter, I; Kahn, SE; Knowler, WC; Hudnall, GE; Lipkin, EW; Kitabchi, AE; ... Look AHEAD Research Group FTO predicts weight regain in the Look AHEAD clinical trial Int J Obes (Lond) 37 12: 1545-52; 2013 PMC3750057
Christophi, CA; Resnick, HE; Ratner, RE; Temprosa, M; Fowler, S; Knowler, WC; Shamoon, H; Barrett-Connor, E; Kahn, SE; ... Diabetes Prevention Program Research Group Confirming glycemic status in the Diabetes Prevention Program: implications for diagnosing diabetes in high risk adults J Diabetes Complications 27 2: 150-7; 2013 PMC3594066
Wander, PL; Boyko, EJ; Leonetti, DL; McNeely, MJ; Kahn, SE; Fujimoto, WY ; Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans Diabetes Care 36 2: 289-93; 2013 PMC3554282
Rosenstock, J; Marx, N; Kahn, SE; Zinman, B; Kastelein, JJ; Lachin, JM; Bluhmki, E; Patel, S; Johansen, OE; ... Woerle, HJ Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the active-comparator CAROLINA Trial Diab Vasc Dis Res 10 4: 289-301; 2013
Look AHEAD Research Group; Wing, RR; Bolin, P; Brancati, FL; Bray, GA; Clark, JM; Coday, M; Crow, RS; Curtis, JM; ... Yanovski, SZ Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes N Engl J Med 369 2: 145-54; 2013 PMC3791615
Smits, MM; Woudstra, P; Utzschneider, KM; Tong, J; Gerchman, F; Faulenbach, M; Carr, DB; Aston-Mourney, K; Chait, A; ... Kahn, SE Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis Ann Epidemiol 23 7: 415-21; 2013 PMC3778191
Fujimoto, WY; Boyko, EJ; Hayashi, T; Kahn, SE; Leonetti, DL; McNeely, MJ; Shuman, WP ; Risk Factors for Type 2 Diabetes: Lessons Learned from Japanese Americans in Seattle J Diabetes Investig 3 3: 212-224; 2012 PMC3393109
Brancati, FL; Evans, M; Furberg, CD; Geller, N; Haffner, S; Kahn, SE; Kaufmann, PG; Lewis, CE; Nathan, DM; ... Look AHEAD Study Group Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study Clin Trials 9 1: 113-24; 2012 PMC3790961
Kahn, SE; Suvag, S; Wright, LA; Utzschneider, KM ; Interactions between genetic background, insulin resistance and beta-cell function Diabetes Obes Metab 14 Suppl 3 46-56; 2012 PMC3634618
Delahanty, LM; Pan, Q; Jablonski, KA; Watson, KE; McCaffery, JM; Shuldiner, A; Kahn, SE; Knowler, WC; Florez, JC; ... Diabetes Prevention Program Research Group Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program Diabetes Care 35 2: 363-6; 2012 PMC3263869
Florez, JC; Jablonski, KA; McAteer, JB; Franks, PW; Mason, CC; Mather, K; Horton, E; Goldberg, R; Dabelea, D; ... Diabetes Prevention Program Research Group Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program PLoS One 7 9: e44424; 2012 PMC3439414
Perreault, L; Pan, Q; Mather, KJ; Watson, KE; Hamman, RF; Kahn, SE; Diabetes Prevention Program Research Group ; Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study Lancet 379 9833: 2243-51; 2012 PMC3555407
Schwartz, AV; Johnson, KC; Kahn, SE; Shepherd, JA; Nevitt, MC; Peters, AL; Walkup, MP; Hodges, A; Williams, CC; ... Look AHEAD Research Group Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial J Bone Miner Res 27 3: 619-27; 2012 PMC3410035
Mather, KJ; Christophi, CA; Jablonski, KA; Knowler, WC; Goldberg, RB; Kahn, SE; Spector, T; Dastani, Z; Waterworth, D; ... Diabetes Prevention Program Research Group Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program Diabet Med 29 12: 1579-88; 2012 PMC3499646
Marina, AL; Utzschneider, KM; Wright, LA; Montgomery, BK; Marcovina, SM; Kahn, SE ; Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and beta-cell function Diabetes Care 35 5: 1119-25; 2012 PMC3329824
Subramanian, SL; Hull, RL; Zraika, S; Aston-Mourney, K; Udayasankar, J; Kahn, SE ; cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets Diabetologia 55 1: 166-74; 2012 PMC3249975
Stevens, RJ; Ali, R; Bankhead, CR; Bethel, MA; Cairns, BJ; Camisasca, RP; Crowe, FL; Farmer, AJ; Harrison, S; ... Holman, RR Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials Diabetologia 55 10: 2593-603; 2012
Smits, MM; Boyko, EJ; Utzschneider, KM; Leonetti, DL; McNeely, MJ; Suvag, S; Wright, LA; Fujimoto, WY; Kahn, SE ; ... Kahn, SE Arm length is associated with type 2 diabetes mellitus in Japanese-Americans Diabetologia 55 6: 1679-84; 2012 PMC3678981
Kahn, SE; Utzschneider, KM ; What's next for diabetes prevention? Diabetes Care 34 7: 1678-80; 2011 PMC3120186
Hoyer, D; Boyko, EJ; McNeely, MJ; Leonetti, DL; Kahn, SE; Fujimoto, WY ; Subcutaneous thigh fat area is unrelated to risk of type 2 diabetes in a prospective study of Japanese Americans Diabetologia 54 11: 2795-800; 2011 PMC3667698
Goedecke, JH; Evans, J; Keswell, D; Stimson, RH; Livingstone, DE; Hayes, P; Adams, K; Dave, JA; Victor, H; ... Kahn, SE Reduced gluteal expression of adipogenic and lipogenic genes in Black South African women is associated with obesity-related insulin resistance J Clin Endocrinol Metab 96 12: E2029-33; 2011 PMC3977037
Wander, PL; Boyko, EJ; Leonetti, DL; McNeely, MJ; Kahn, SE; Fujimoto, WY ; Greater hand-grip strength predicts a lower risk of developing type 2 diabetes over 10 years in leaner Japanese Americans Diabetes Res Clin Pract 92 2: 261-4; 2011 PMC3910507
Aston-Mourney, K; Hull, RL; Zraika, S; Udayasankar, J; Subramanian, SL; Kahn, SE ; Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets Diabetologia 54 7: 1756-65; 2011 PMC3220951