A study published in JAMA Network Open found that the US reported 12.7 million excess deaths from 1999 to 2022, more than any other high-income country. Annual excess deaths jumped from about 346,000 in 1999 to 905,000 in 2022. Circulatory diseases were the leading cause, along with deaths related to diabetes, kidney and metabolic diseases. Obesity factored into higher rates of cardiovascular disease in Americans ages 45 to 64.
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