Alliance for Pandemic Preparedness

January 13, 2021

Serologic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Infection in Hospital Health Care Workers

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[Pre-print, not peer-reviewed] A prospective study of 801 healthcare workers (HCW) conducted from May-June 2020 found that SARS-CoV-2 incidence was highest in HCW working in COVID-19 patient care (13%), as compared with non-COVID-19 patient care (7%, HR=2.2) and not working in patient care (4%, HR=3.9). Within the group caring for COVID-19 patients, SARS-CoV-2 cumulative incidence was highest among those working on COVID-19 wards (26%), as compared to ICUs (7%, HR=3.6), and the emergency room (8%, HR=3.3). Phylogenetic analyses on COVID-19 wards identified multiple potential HCW-to-HCW transmission clusters, while no patient-to-HCW transmission clusters were identified. 

Sikkens et al. (Jan 12, 2021). Serologic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Infection in Hospital Health Care Workers. Pre-print downloaded Jan 13 from https://medrxiv.org/cgi/content/short/2021.01.10.21249440