Alliance for Pandemic Preparedness

January 25, 2021

Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany

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A multicenter, cross-sectional study of SARS-CoV-2 seroprevalence among children aged 1-10 years (n=2,482) in Germany and a corresponding parent (n=2,482) found that between April 22 and May 15 2020, the estimated seroprevalence was low in parents (1.8%) and 3-fold lower in children (0.6%). Only two participants (0.04%) tested positive for SARS-CoV-2 RNA. Among 56 families with at least 1 seropositive child or parent, the risk of a seropositive parent and seronegative dyad was 4.3 times higher than the risk of a seronegative parent and seropositive child dyad. Virus-neutralizing activity was observed for 94% of 70 IgG-positive serum samples.

Tönshoff et al. (Jan 22, 2021). Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany. JAMA Pediatrics. https://doi.org/10.1001/jamapediatrics.2021.0001