Alliance for Pandemic Preparedness

March 9, 2021

COVID-19 Vaccine Response in Pregnant and Lactating Women a Cohort Study

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  • [Pre-print, not peer-reviewed] The Pfizer-BioNTech and Moderna vaccines elicited similar immune responses among pregnant (n=84) and lactating (n=31) women compared to non-pregnant reproductive-age women (n=16). All vaccine-induced SARS-CoV-2-specific antibody titers were higher compared to titers from a group of pregnant women (n=37) that had SARS-CoV-2 infection 4-12 weeks prior. Vaccine-induced antibodies were detected in all umbilical cord blood (n=10) and breastmilk samples (n=31), although only IgG and not IgA antibodies were increased in maternal blood and breastmilk following vaccination. No differences were noted in reactogenicity across the groups.

Gray et al. (Mar 8, 2021). COVID-19 Vaccine Response in Pregnant and Lactating Women a Cohort Study. Pre-print downloaded Mar 9 from https://doi.org/10.1101/2021.03.07.21253094