Alliance for Pandemic Preparedness

April 29, 2021

Maternal Antibody Response, Neutralizing Potency, and Placental Antibody Transfer After Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) Infection

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  • Among maternal blood samples from SARS-CoV-2 positive patients obtained after delivery (n=32), higher median anti-RBD IgG titers were significantly associated with symptomatic (vs. asymptomatic) infection but not with having a PCR-positive test more than 14 days earlier (vs. PCR-positive test within 14 days). Paired cord blood samples also obtained after delivery show that median cord/maternal anti-RBD IgG antibody ratio was 0.81. Neutralizing antibodies were detected in 94% of maternal blood samples, but only in 25% of cord blood samples. The authors note the efficiency of transplacental antibody transfer was lower than expected.

Joseph et al. (Apr 28, 2021). Maternal Antibody Response, Neutralizing Potency, and Placental Antibody Transfer After Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) Infection. Obstetrics & Gynecology. https://doi.org/10.1097/AOG.0000000000004440