October 30, 2020
COVID-19 LITERATURE SITUATION REPORT OCT. 30, 2020
Oxygen saturation did not decline among adults over age 65 years while they wore non-medical face masks
October 29, 2020
COVID-19 Testing and Cases in Immigration Detention Centers, April-August 2020
COVID-19 case rates among detainees in US Immigration and Customs Enforcement (ICE) facilities increased every month from April to August, with increases only partially explained by increased testing. ICE facilities reported 5379 cumulative COVID-19 cases and 6 deaths among its detainees through August 2020. Twenty facilities (of 135) accounted for 71% of cases. The monthly…
What Factors Drive the Satisfaction of Citizens on Governments’ Responses to COVID-19?
Analysis of a 14-country dataset suggests that people place stronger attention on their government’s response performance, measured by the number of confirmed COVID-19 cases and deaths, rather than containment and health policies that are initiated. Satisfaction in the government response ranged from 46% and 47% in the UK and US, respectively, to 94% and 95%…
Risk of Hospital Admission with Coronavirus Disease 2019 in Healthcare Workers and Their Households: Nationwide Linkage Cohort Study
A nationwide cohort study in Scotland (n=158,445) found that despite low absolute risk, patient facing healthcare workers and their household members had a higher relative risk of hospital admission due to COVID-19 compared to non-patient facing healthcare workers and their household members. Risk of COVID-19-related hospital admission was 3-fold higher among patient facing healthcare workers…
Comparative Performance of Private Equity–Owned US Nursing Homes During the COVID-19 Pandemic
A cross-sectional study of 11,470 nursing homes found that private equity (PE) owned nursing homes performed comparably on resident COVID-19 cases and deaths despite more frequent shortages of PPE in PE-owned vs. other types of nursing homes. No statistically significant differences in COVID-19 cases, COVID-19 deaths, nor deaths from all causes were detected between PE-owned…
Robust Neutralizing Antibodies to SARS-CoV-2 Infection Persist for Months
Analysis of a serology dataset from patients admitted to a New York City hospital with confirmed or suspected SARS-CoV-2 infection (n=30,082) showed that the vast majority of individuals (~92%) had moderate-to-high titers (> 1:320) of anti-spike antibodies with 90% of seroconverters making detectable neutralizing antibodies. Additionally, antibody titers from a cohort of 121 plasma donors…
Positive RT-PCR Test Results in 420 Patients Recovered From COVID-19 in Wuhan: An Observational Study
An observational study among 420 recovered COVID-19 patients in Wuhan, China suggests that recurrence rates (based on RT-PCR tests) may be lower among patients receiving a comprehensive intervention. The intervention consisted of a combination of treatments including Baduanjin execise, Chinese herbal medicine, moxibustion with acupoint application, and foot baths. Recurrence positivity rates were significantly lower…
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
A phase 2 randomized placebo-controlled trial (n=452) interim analysis found that patients who received a 2800mg dose of monoclonal antibody LY-CoV555 could reduce SARS-CoV-2 log viral load by 3.4-fold after 11 days compared to patients receiving placebo, corresponding to a 0.53 log viral load reduction (95% CI: -0.98 to -0.08). Other patients receiving a 700mg…
Inhaled Corticosteroids and COVID-19 Risk and Mortality: A Nationwide Cohort Study
Use of inhaled corticosteroids (ICS) among patients with COPD or asthma was not associated with a COVID-19 diagnosis in a nationwide study conducted in Korea. In a nested case control study among patients with COPD with 640 COVID-19 cases and 2560 matched controls without COVID-19, ICS use was not associated with COVID-19 (aOR=1.02, 95% CI,…
Emergence and Spread of a SARS-CoV-2 Variant through Europe in the Summer of 2020
[Pre-print, not peer reviewed] Phylogenetic analysis found that a SARS-CoV-2 variant has emerged in Spain since mid-July with a frequency over 40%. Sequences in this cluster differ from ancestral sequences at 6 or more positions. The variant spread to multiple European countries, with frequencies increasing from low values prior to mid-July to 40-70% in Switzerland,…
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