Article Summary
February 1, 2021
Mapping a Pandemic SARS-CoV-2 Seropositivity in the United States
[Pre-print, not peer-reviewed] Between May and July 2020, there were an estimated 4.8 undiagnosed cases of COVID-19 for every case diagnosed in the United States, and an estimated 16.8 million undiagnosed cases by mid-July, based on findings from a serostudy conducted among adults (n = 11,3182) who had not been diagnosed with COVID-19. Undiagnosed seropositivity…
Early COVID-19 First-Dose Vaccination Coverage Among Residents and Staff Members of Skilled Nursing Facilities Participating in the Pharmacy Partnership for Long-Term Care Program — United States, December 2020–January 2021. MMWR
As of January 17, 2021, a median of 77.8% of residents (IQR: 61.3-93.1%) and 37.5% of staff members (IQR: 23.2-56.8%) across 11,460 skilled nursing facilities received ≥1 vaccine dose through the CDC Pharmacy Partnership for Long-Term Care Program, a public-private partnership between the CDC and CVS, Walgreens, and Managed Healthcare Associates. A total of 713,909…
Robust Spike Antibody Responses and Increased Reactogenicity in Seropositive Individuals after a Single Dose of SARS-CoV-2 MRNA Vaccine
[Pre-print, not peer-reviewed] One dose of mRNA vaccine elicited a rapid and strong immune response among individuals already seropositive for SARS-CoV-2, with antibody titers 10-20 times higher than those of naïve vaccinees at the same timepoint. Seropositive individuals also had antibody titers that exceeded by >10-fold the median titers among individuals without previous infection who…
Post-Vaccination COVID-19 among Healthcare Workers, Israel
Among 4,081 vaccinated healthcare workers in Israel, 22 (0.54%) developed laboratory-confirmed COVID-19 between 1–10 days (median 3.5) post-immunization. Among these 22 individuals, 13 were tested because they experienced symptoms including fever, chills, cough, headache, and sore throat. 11 people had suspected community-related exposure, 4 of whom were exposed before their vaccination date. Among symptomatic individuals,…
Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios
IgG antibodies to SARS-CoV-2 from pregnant women with symptomatic or asymptomatic SARS-CoV-2 infection were transferred across the placenta, and cord antibody concentrations were positively correlated with maternal IgG concentrations (r=0.9). IgG antibodies were detected in cord blood from 72 of 83 newborns (87%), while IgM antibodies were not detected in any cord blood samples. Eleven…
Demographic Characteristics of Persons Vaccinated During the First Month of the COVID-19 Vaccination Program — United States, December 14, 2020–January 14, 2021
During the first month of the US COVID-19 vaccination program (December 14, 2020-January 14, 2021) nearly 13 million people received at least one dose of the vaccine. Race/ethnicity was unknown or not reported for 6,222,052 (48.1%) persons initiating vaccination. Among individuals for whom demographic data were available, 63% were women, and 60% were non-Hispanic white,…
January 29, 2021
Impact of COVID-19 on Cervical Cancer Screening Rates Among Women Aged 21-65 Years in a Large Integrated Health Care System – Southern California, January 1-September 30, 2019, and January 1-September 30, 2020
Cervical cancer screening rates decreased among 1.5 million women served by Kaiser Permanente Southern California during stay-at-home orders implemented in March 2020 in response to the COVID-19 pandemic. Compared with 2019 screening rates, 2020 screening rates among women aged 21-29 years and aged 30-65 years were 78% and 82% lower, respectively, during the stay-at-home order…
Estimating Aerosol Transmission Risk of SARS-CoV-2 in New York City Public Schools During Reopening
Using previously collected indoor air quality data from New York City public schools, Pavilonis et al. estimated the probability of in-classroom transmission to be 5% for student-to-student transmission, 14% for student-to-teacher transmission, and 20% for teacher-to-student transmission after the introduction of one infectious person into the classroom. Consistent mask wearing by both students and teachers…
Evaluation of COVID-19 vaccination strategies with a delayed second dose
[Pre-print, not peer-reviewed] Extending the interval between doses of the Moderna vaccine from 4 weeks to 9-12 weeks could prevent additional infections, hospitalizations, and deaths according to an agent-based model. However, there was no clear advantage for delaying the second dose of the Pfizer-BioNTech vaccines beyond the standard 3-week interval. This is largely attributable to…
More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
[Pre-print, not peer-reviewed] Eighty percent (95%CI: 65% to 92%) of persons infected with SARS-CoV-2 developed one or more long-term symptoms, according to a systematic review and meta-analysis (n=47,910 patients) assessing long-term effects of COVID-19. Follow-up time of study participants ranged from 15 to 110 days post-viral infection. The age of the study participants ranged between…
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