Article Summary
October 16, 2020
Race, Ethnicity, and Age Trends in Persons Who Died from COVID-19 — United States, May–August 2020
Among COVID-19–associated deaths reported to the US National Vital Statistics System from May to August, deaths in people over the age of 65 and members of minority racial and ethnic groups were disproportionately represented. Analysis of 114,411 COVID-19–associated deaths found that 51% were among non-Hispanic white individuals, 24% were among Hispanic or Latino individuals, and…
A Model-Based Evaluation of the Efficacy of COVID-19 Social Distancing, Testing and Hospital Triage Policies
A model examining the effects of policy choices regarding social distancing, testing, and hospital triaging found that the most successful practices for reducing COVID-19 mortality were social distancing, increasing test availability while reducing the delay between administration and results, and prioritizing the care of the least-severely infected patients. The model simulated how SARS-CoV-2 spreads in…
Decreasing Median Age of COVID-19 Cases in the United States—Changing Epidemiology or Changing Surveillance?
A retrospective review of SARS-CoV-2-positive molecular testing results in the US between early (March-April 2020) and later periods (June-July 2020) found a trend toward decreasing age among people with laboratory-confirmed SARS-CoV-2 infection, but that these trends seem to be specific to the outpatient population. In the early period, the median age of individuals testing positive…
Heterogeneity in Testing, Diagnosis and Outcome in SARS-CoV-2 Infection across Outbreak Settings in the Greater Toronto Area, Canada: An Observational Study
A population-based prospective cohort study of residents of long-term care homes, people living in shelters, and members of the general population in Toronto, Canada found that residents of long-term care homes were 2.4 times more likely to test positive for SARS-CoV-2 than the general population and those who received a diagnosis of COVID-19 were 1.4…
Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG
Immunity to SARS-CoV-2 infection may be mediated through T-cells, even among those with undetectable levels of antibodies against the virus. A study of immune responses against severe SARS-CoV-2 among a group of convalescent, potential blood donors in Germany found T-cell immunity against SARS-CoV-2 in 78% of volunteers who had a PCR-confirmed SARS-CoV-2 infection but had…
Repurposed Antiviral Drugs for COVID-19 Interim WHO SOLIDARITY Trial Results
[Pre-print, not peer reviewed] Interim results for the original four drugs in the WHO Solidarity trial indicated that remdesivir, hydroxychloroquine, lopinavir/ritonavir and interferon regimens did not appear to reduce mortality, initiation of ventilation, or duration of hospital stay. Out of 11,266 adults in 30 countries who were randomized, 1,253 deaths were reported. Kaplan-Meier analysis of…
Capillary Whole-Blood IgG-IgM COVID-19 Self-Test as a Serological Screening Tool for SARS-CoV-2 Infection Adapted to the General Public
Observations from a cross-sectional, general adult population pilot study in France indicated high practicability and satisfaction of SARS-CoV-2 IgG-IgM self-testing using the Exacto COVID-19 self-test. The study used a variety of questionnaires to determine if participants could both use the test and interpret its results correctly. All 167 participants correctly used the self-test, although 12 asked…
COVID-19 Transmission in US Child Care Programs
In a study of COVID-19 outcomes among child care providers who provided in-person child care during the first three months of the pandemic versus those who did not, no association was found between exposure to child care and testing positive for or being hospitalized with COVID-19 in both unmatched (OR =1.06) and matched (OR=0.94) analyses….
SARS-CoV-2 Infections in Italian Schools Preliminary Findings after One Month of School Opening during the Second Wave of the Pandemic
[Pre-print, not peer reviewed] Preliminary data from a study of SARS-CoV-2 transmission in Italian schools showed that transmission appears to be low among younger students. As of October 5, a total of 1,350 SARS-CoV-2 infections had been registered in Italian territory schools in an online database of media news about infections in schools. Schools reported…
Transmission of SARS-CoV-2 from Children and Adolescents
[Pre-print, not peer reviewed] Children and adolescents who acquired SARS-CoV-2 infection during an overnight camp in June transmitted the virus to both pediatric and adult contacts in their households, with 10% of the adult secondary cases requiring hospitalization, based on a retrospective cohort study from Georgia. Among 526 tested household contacts of 224 infected individuals,…
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