Article Summary
October 15, 2020
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
In an ongoing randomized controlled phase 1 trial of RNA-vaccine candidates BNT162b1 and BNT162b2 (n=195), both vaccine candidates elicited similar dose-dependent SARS-CoV-2 neutralizing titers, which were similar to titers of a panel of SARS-CoV-2 convalescent serum samples. BNT162b2 was associated with a lower incidence and severity of systemic reactions than BNT162b1, particularly in older adults,…
Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial
In a randomized placebo-controlled phase 1/2 trial of a SARS-CoV-2 vaccine candidate, BBIBP-CorV, 192 healthy adults were randomized to receive vaccine (2, 4, or 8 μg) or placebo in a 3:1 ratio, stratified by age (18-59 and ≥60) in phase 1. Adverse reactions within the first 7 days of inoculation were reported by 42 (29%)…
Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection
Geometric mean SARS-CoV-2 neutralizing antibody titers of 18 SARS-CoV-2 positive patients in South Korea decreased from 219.4 at 2 months to 143.7 at 5 months (p=0.03) after infection, indicating a waning antibody response. The decline was significantly associated with antibody levels at 2 months and happened more frequently in symptomatic patients who developed pneumonia (n=11),…
Healthcare Workers with Mild Asymptomatic SARS-CoV-2 Infection Show T Cell Responses and Neutralising Antibodies after the First Wave
[Pre-print, not peer reviewed] A cohort study of 136 healthcare workers in the UK found that 90% of the 76 workers with mild or asymptomatic SARS-CoV-2 infection had detectable neutralizing antibodies at the beginning of the lockdown and 66% of the same workers had them after 16-18 weeks. T-cell responses tended to be lower among…
Clinical Characteristics Symptoms Management and Health Outcomes in 8598 Pregnant Women Diagnosed with COVID-19 Compared to 27510 with Seasonal Influenza in France Spain and the US
[Pre-print, not peer reviewed] A network cohort analysis of 8,598 pregnant women from France, Spain, and the US with COVID-19 found that women who were eventually hospitalized were more likely to have kidney impairment and anemia. Compared to a cohort of 27,510 pregnant women diagnosed with influenza during the 2017-2018 flu season, pregnant women with…
An Outbreak of COVID-19 Associated with a Recreational Hockey Game
A SARS-CoV-2 outbreak was identified in an indoor hockey game in Tampa, Florida in June. The index case experienced symptoms one day after the game; 2 days later he received a positive antigen test. Overall, 62% (13 of 21) players experienced illness 2-5 days after the game (8 teammates, 5 members of the other team),…
Social Contact Patterns among Employees in 3 U.S. Companies during Early Phases of the COVID-19 Pandemic
[Pre-print, not peer reviewed] A cross-sectional study used data from 2 contact diaries from employees from 2 consulting companies and 1 university department in Georgia to measure the number of contacts per person per day between April and June. Among 3835 employees, 304 (8%) completed both diaries and had a median of 2 contacts per…
Demographic Characteristics, Experiences, and Beliefs Associated with Hand Hygiene Among Adults During the COVID-19 Pandemic — United States
Among 4,817 US adults responding to an internet-based survey administered in June, 85% reported frequent hand hygiene (handwashing or hand sanitizing) after contact with public surfaces. Males, young adults (age 18-24), respondents less concerned about risk for SARS-CoV-2 infection, and respondents who did not personally know someone who had received a positive SARS-CoV-2 test reported…
October 14, 2020
High Food Insecurity in Latinx Families and Associated COVID-19 Infection in the Greater Bay Area California
[Preprint, not peer-reviewed] Increased food insecurity was found in Latinx communities in the San Francisco Bay Area during the COVID-19 pandemic. A series of phone interviews from three separate Latinx cohorts conducted from March to September 2020 in the San Francisco Bay Area (total 375 households, 1,875 individuals) found that only 47% of surveyed Latinx…
Rapid and Low-Cost Sampling for Detection of Airborne SARS-CoV-2 in Dehumidifier Condensate
[Preprint, not peer-reviewed] A simple technique of sampling condensate from a commercial dehumidifier at 24-48 hour intervals identified SARS-CoV2 in a hospital setting. Four portable dehumidifiers obtained from Amazon were stationed at various locations in a Maryland hospital ward over 3 separate 1-week periods (June 29- July 5, July 22-August 10 and September 3-10). Among…
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