Article Summary
September 9, 2020
Assessing COVID-19 Transmission to Healthcare Personnel: The Global ACT-HCP Case-Control Study
• Healthcare personnel who had non-aerosol-generating contact with COVID-19 patients were more likely to be infected with SARS-CoV-2 (aOR 1.4, 95%CI 1.0-1.9). The proper use of appropriate PPE was associated with lower risk of infection. These findings were based on an online survey of 1,130 healthcare personnel (244 cases with laboratory-confirmed COVID-19, 22%) from 67…
Acute Kidney Injury and Kidney Replacement Therapy in COVID-19: A Systematic Review and Meta-Analysis
• A meta-analysis of 142 studies (49,048 hospitalized COVID-19 patients) reported a pooled incidence of acute kidney injury (AKI) of 29% (95%CI 20%-40%) in the US and Europe (20 studies) and 6% (95%CI 4%-7%) in China (62 studies). Overall AKI was associated with 4.6-fold increased mortality. Fu et al. (Sept 2, 2020). Acute Kidney Injury…
Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children. JAMA Network Open
• US children with COVID-19 or seasonal influenza had similar rates of hospitalization, intensive care unit admission, and mechanical ventilator use. Song et al. found that among 315 children with laboratory-confirmed COVID-19 and 1,402 children with laboratory-confirmed influenza A or B there was no difference in the level of hospitalization (17% vs 21%), intensive care…
Clinical Outcomes in Young US Adults Hospitalized With COVID-19
Young adults age 18 to 34 years who were hospitalized with COVID-19 in the US (n=3,222) experienced substantial rates of adverse outcomes, including 21% who required intensive care, 10% who required mechanical ventilation, and 3% who died. Morbid obesity, hypertension, and diabetes were common among hospitalized young adults with COVID-19 and were associated with 1.5…
Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease
• An ultra-sensitive assay can detect SARS-CoV-2 S1 subunit and nucleocapsid antigens in plasma and saliva of COVID-19 patients, with higher concentrations associated with ICU admission and intubation within one day. The authors state that while these antigens have been detected previously in nasopharyngeal swab specimens, this is the first report of their detection in…
Adverse Outcomes and Mortality in Users of Non-Steroidal Anti-Inflammatory Drugs Who Tested Positive for SARS-CoV-2: A Danish Nationwide Cohort Study
Use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with SARS-CoV-2 infection was not associated with 30-day mortality, hospitalization, ICU admission, mechanical ventilation, or renal replacement therapy in a study of 9,236 SARS-CoV-2-positive Danish residents, of whom 3% filled an NSAID prescription. [EDITORIAL NOTE: A summary of a pre-print version of this manuscript appeared in the…
COVID-19 Prevalence among People Experiencing Homelessness and Homelessness Service Staff during Early Community Transmission in Atlanta, Georgia, April-May 2020
In Atlanta, Georgia, people experiencing homelessness who were living in shelters had higher SARS-CoV-2 prevalence compared with those living unsheltered (2% vs. 0.5%). These findings were based on a survey of 2,860 individuals at 24 shelters and 9 unsheltered outreach events undergoing SARS-CoV-2 testing (April 7-May 6, 2020). Prevalence by shelter ranged from 0% to…
Decreasing High Risk Exposures for Healthcare-Workers through Universal Masking and Universal SARS-CoV-2 Testing upon Entry to a Tertiary Care Facility
Implementation of universal masking and universal SARS-CoV-2 testing at admission at an academic referral medical center in the Southeastern US dramatically decreased high risk exposures to SARS-CoV-2 (e.g. exposures without appropriate personal protective equipment) for healthcare workers. Universal masking decreased the per patient day rate of high risk exposures by 68% and universal testing further…
September 8, 2020
Variations in State-Level SARS-COV-2 Testing Recommendations in the United States March-July 2020
[Pre-print, not peer-reviewed] As of July 2020, only 16 states had recommended asymptomatic testing of the public, while 9 states actively recommended against it. The per capita rate of COVID-19 tests reported in each state correlated with more permissive testing recommendations and with higher epidemic intensity. Higher per capita testing was weakly associated with more…
Reaching Invisible and Unprotected Workers on Farms during the Coronavirus Pandemic
The Cornell Farmworker Program, in partnership with Finger Lakes Community Health, implemented an approach to support farmworkers by creating a language concordant text messaging system that reached over 3,000 farmworkers and a webinar to communicate COVID-19 information regarding safety and regulations in which over 500 farmworkers participated. Dudley. (Sept 7, 2020). Reaching Invisible and Unprotected…
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