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June 26, 2020
Influenza Vaccination and COVID19 Mortality in the USA
[pre-print, not peer-reviewed] A county-level analysis found an inverse association between influenza vaccination rates among people age 65 or older and the COVID-19 mortality rate in the US (β values -3.29 to -5.65 depending on approach to adjustment). This effect persisted after adjustment for potential confounders related to demographic, clinical, and environmental characteristics, and was robust to several sensitivity analyses. Zanettini et al. (June 26, 2020). Influenza Vaccination and COVID19 Mortality in…
Contact Tracing Evaluation for COVID-19 Transmission during the Reopening Phase in a Rural College Town
[pre-print, not peer-reviewed] Moon and Scoglio built an individual-based contact network model and a compartmental transmission model for COVID-19. They coupled these models to assess the effectiveness of contact tracing for COVID-19 control under four different re-opening strategies ranging from 0% to 75% of contacts traced. They found tracing 20% of contacts is enough to reduce the…
Impact of Lockdown on the Epidemic Dynamics of COVID-19 in France
Roques et al. modeled the COVID-19 epidemic in France, and estimated that lockdown reduced the effective reproductive number by a factor of 7 (Re = 0.47, 95%CI 0.45, 0.50), and that only 3.7% of the population (95%CI 3.0%, 4.8%) would be infected by the beginning of May, far below the herd immunity threshold. Roques et al. (June 5, 2020). Impact of Lockdown on the…
Clinical And Analytical Performance Of An Automated Serological Test That Identifies S1/S2 Neutralizing IgG In COVID-19 Patients Semiquantitatively.
Bonelli et al. found that the LIAISON SARS-CoV-2 S1/S2 IgG antibody assay, a semi–quantitative antibody test that has a throughput of 170 tests/hour with the first tests available within 35 minutes, has a sensitivity of 85.7% and a specificity of 97%-98.5% for samples collected 15 or more days after diagnosis. Bonelli et al. (June 24, 2020). Clinical And Analytical Performance Of An Automated Serological Test That Identifies S1/S2 Neutralizing IgG In COVID-19 Patients Semiquantitatively….
Large-Scale Implementation of Pooled RNA Extraction and RT-PCR for SARS-CoV-2 Detection
Ben-Ami et al. found that pooled testing, using a strategy known as Dorfman pooling in batches of 8 samples, retained the sensitivity of individual testing. They then applied this strategy to 26,576 clinical samples, and demonstrated a 7.3–fold increase in throughput. All pools with positive samples were found to be positive, all pools with negative samples were negative,…
Antibody Tests for Identification of Current and Past Infection with SARS-CoV-2
A literature review and meta-analysis (n=57 studies; 15,976 samples) compared 25 commercial antibody tests and numerous in-house assays. Pooled results across the 38 studies, stratified by time since symptom onset, found sensitivity was low during the first week (less than 30.1% across IgG, IgM, IgA, IgM/IgG, and total antibodies) and peaked in the third week…
Evaluation of Rapid Antigen Test for Detection of SARS-CoV-2 Virus
Mak et al. found that the rapid BIOCREDIT COVID-19 Ag test for SARS-CoV-2 antigen, which can provide results within 30 minutes and without specialized equipment, had a markedly lower sensitivity than viral culture or RT-PCR (29% to 82% compared to RT-PCR positive samples). These results indicate that testing of patients suspected of SARS-CoV-2 infection with antigen-based assay may produce more false negative results in clinical…
Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy
Among people living with HIV, those who were one an anti-retroviral therapy (ART) regimen that included the medications tenofovir disoproxil fumarate (TDF) with emtricitabine (FTC) had lower risk for COVID-19 and related hospitalization compared to HIV-infected individuals on other ART regimens. del Amo et al. (June 26, 2020). Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy. Annals of Internal…
Shut and Re-Open the Role of Schools in the Spread of COVID-19 in Europe
[pre-print, not peer-reviewed] Stage et al. compared daily hospitalization trends in northern European countries (Denmark, Norway, Sweden, and Germany), and found that the growth rate of COVID-19 cases declined approximately 9 days after implementation of school closures. Limited school attendance did not appear to significantly affect transmission. Reopening of schools for all students in countries with low community transmission (Denmark and Norway) has not…
June 25, 2020
Modeling Quarantine during Epidemics and Mass-Testing Using Drones
Sedov et al. incorporate quarantining into a traditional Susceptible-Infected-Recovered (SIR) model and explore the potential of using drones to deliver tests. Using a medium-sized city (about 100,000 people) in Sweden, the investigators found that the model predicts a substantial decrease in peak number of infected people without increasing the duration of the epidemic. The number of days needed to collect tests…
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