Article Summary
March 3, 2020
Clinical Data on Hospital Environmental Hygiene Monitoring and Medical Staff Protection during the Coronavirus Disease 2019 Outbreak
Jiang et al describe a study of air and surface contamination in a Chinese hospital to evaluate environmental hygiene and to support improved infection control practices. Jiang et al. (Mar 2, 2020). Clinical Data on Hospital Environmental Hygiene Monitoring and Medical Staff Protection during the Coronavirus Disease 2019 Outbreak. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2020.02.25.20028043
Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients
Detectable serum SARS-CoV-2 viral load appears to be associated with increased illness severity. Inflammatory cytokine IL-6 levels were also 10 times higher among critically ill patients compared to other patients. Chen et al. (Mar 3, 2020). Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill…
Convalescent plasma as a potential therapy for COVID-19
Another study has drawn attention to the possibility of convalescent plasma as a treatment option for COVID-19, calling for further safety and efficacy testing. Chen et al. (Feb 27, 2020). Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis. https://doi.org/10.1016/S1473-3099(20)30141-9
Clinical significance of IgM and IgG test for diagnosis of highly suspected COVID-19 infection
A study of 57 patients, some with and some without confirmed COVID-19, was conducted to assess the accuracy and utility of IgM and IgG serological testing. Jia et al. (Mar 3, 2020). Clinical significance of IgM and IgG test for diagnosis of highly suspected COVID-19 infection. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2020.02.28.20029025
Laboratory abnormalities in patients with COVID-2019 infection
This paper offers a review of current literature on laboratory considerations for testing for COVID-19 and descriptions of specific abnormalities used for diagnostic and prognostic decisions. Lippi and Plebani (Mar 3, 2020). Laboratory abnormalities in patients with COVID-2019 infection. CCLM. https://doi.org/10.1515/cclm-2020-0198
Rapid Detection of SARS-CoV-2 Using Reverse transcription RT-LAMP method
This study evaluated the use of RT-LAMP for diagnosing COVID-19. Sensitivity was similar to RT-PCR and specificity was 99%. Yang et al. (Mar 2, 2020). Rapid Detection of SARS-CoV-2 Using Reverse transcription RT-LAMP method. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2020.03.02.20030130
Fecal specimen diagnosis 2019 Novel Coronavirus–Infected Pneumonia
A case series study found that fecal specimens were equally accurate in detecting SARS-CoV-2 compared to nucleic acid tests. Patients with positive stool samples did not exhibit gastrointestinal symptoms and presence of the virus in the stool was not associated with the severity of lung infection. Zhang et al. (Mar 3, 2020). Fecal specimen diagnosis…
Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019
Seroconversion was evaluated for 173 COVID-19 patients in China. Less than 40% of patients showed presence of antibodies during the first 7 days of illness, but this rapidly increased over subsequent days to 100% (Ab), 94.3% (IgM), and 79.8% (IgG). Combining RNA and antibody tests significantly improved diagnostic sensitivity, even in the first 7 days…
Closed environments facilitate secondary transmission of coronavirus disease 2019 (COVID-19)
Closed environments appear to contribute to secondary transmission of COVID-19 and also promote superspreading events. Declining incidence rates in China after social distancing was enforced further supports this conclusion. Nishiura et al. (Mar 3, 2020). Closed environments facilitate secondary transmission of coronavirus disease 2019 (COVID-19). Pre-print downloaded Mar 3 from https://doi.org/10.1101/2020.02.28.20029272
A Chinese Case of COVID-19 Did Not Show Infectivity During the Incubation Period: Based on an Epidemiological Survey
While current evidence points to probably asymptomatic transmission of COVID-19, the evidence is not entirely definitive. This case study did not find evidence of asymptomatic transmission after an epidemiologic assessment of a confirmed patient in Korea. Bae (Mar 2, 2020).A Chinese Case of COVID-19 Did Not Show Infectivity During the Incubation Period: Based on an…
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