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April 21, 2021
The Risk of Symptomatic Reinfection during the Second COVID-19 Wave in Individuals Previously Exposed to SARS-CoV-2
[Pre-print, not peer-reviewed] In a cohort study in Italy, the adjusted odds ratio for developing symptomatic SARS-CoV-2 infection with SARS-CoV-2 IgG antibodies was 0.05 in the six months following antibody measurement when compared to individuals who were seronegative. The cumulative incidence of laboratory-confirmed, symptomatic infections among IgG-negative and IgG positive cohorts was 2.7% in seronegative…
Postvaccination SARS-CoV-2 Infections Among Skilled Nursing Facility Residents and Staff Members — Chicago, Illinois, December 2020–March 2021
Twenty-two possible breakthrough SARS-CoV-2 infections (infection ≥14 days after the second vaccine dose) were identified among skilled nursing facility staff (n = 10) and residents (n = 12) across 15 facilities in the Chicago, IL area. Among these cases, 14 (64%) were asymptomatic, two residents were hospitalized, and one resident died due to multiple concurrent…
COVID-19 Dynamics after a National Immunization Program in Israel
Two months after the initiation of the SARS-CoV-2 vaccination (Pfizer-BioNTech) campaign in Israel, there were declines in the number of cases (by 77%), percentage of positive tests (by 45%), number of hospitalizations (by 68%), and number of severe hospitalizations (by 67%) compared to peak values. The authors suggest that these results are likely driven by…
A Real World Evaluation of the Safety and Immunogenicity of the Covishield Vaccine ChAdOx1 NCoV- 19 Corona Virus Vaccine (Recombinant) in Health Care Workers (HCW) in National Capital Region (NCR) of India A Preliminary Report
[Pre-print, not peer-reviewed] A real-world study of the safety and immunogenicity of one dose of the Covishield (Oxford-AstraZeneca) vaccine among healthcare workers in India (n = 1,638) found that 79.0% were seropositive 2 weeks after the 1st dose, an increase from the 48.2% who were seropositive at baseline. Among those with prior infection, 98.2% were…
Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection Elicits Durable Neutralizing Antibody Responses in Children and Adolescents
[Pre-print, not peer-reviewed] Children and adolescents with mild or asymptomatic SARS-CoV-2 infection (n = 69) had robust IgM, IgA, and IgG antibody responses to a range of antigens at the time of infection, and at 2- and 4- month follow-up. Neutralizing activity was still detectable 4 months after infection in 94% of participants, and antibody…
COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021
Unvaccinated residents and healthcare personnel (HCP) at a Kentucky skilled nursing facility had a 3 and 4.1-fold higher risk of infection compared to residents and HCP who were vaccinated with the Pfrizer-BioNTech mRNA vaccine, respectively, during a SARS-CoV-2 outbreak identified on March 1, 2021. This outbreak was with a newly-introduced variant to the region called…
April 20, 2021
The Increase in the Risk of Severity and Fatality Rate of Covid-19 in Southern Brazil after the Emergence of the Variant of Concern (VOC) SARS-CoV-2 P.1 Was Greater among Young Adults without Pre-Existing Risk Conditions
[Pre-print, not peer-reviewed] A higher proportion of younger patients (age <60 years) were observed among severe COVID-19 cases leading to death (28%) in the second wave in Brazil (February 2021) as compared to the first wave (18%) (November-December 2020). This second wave was predominantly the P.1 variant. Similarly, a higher proportion of patients without pre-existing…
Substance Use and Mental Health in Pregnant Women during the COVID-19 Pandemic
Elevated stress, depressive symptoms, and poorer mental/emotional health prior the COVID-19 pandemic were significantly associated with substance abuse during the pandemic, according to a cross-sectional online survey (n=83) conducted in April 2020. Smith et al. (Apr 17, 2021). Substance Use and Mental Health in Pregnant Women during the COVID-19 Pandemic. Journal of Reproductive and Infant Psychology….
Multisystem Inflammatory Syndrome in Infants <12 Months of Age, United States, May 2020–January 2021
A total of 83 of 85 (98%) of infants aged <12 months with multisystem inflammatory syndrome (MIS-C) tested positive for SARS-CoV-2 by either PCR or serology, according to data from a US surveillance system from May 2020 to January 2021. Rash, diarrhea, and vomiting were the most common reported symptoms and the median time from…
Symptoms, Pulmonary Function and Functional Capacity Four Months after COVID-19
Fatigue and shortness of breath with exertion were present four months after infection in approximately 70% of COVID-19 survivors, according to a prospective study of hospitalized COVID-19 patients in Ottawa, Canada (n=25). Among non-hospitalized survivors (n=38), fatigue and exertional breathlessness persisted in 71% and 55%, respectively. At follow-up, forced vital capacity, total lung capacity, peak…
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