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Tag: clinical characteristics
June 15, 2021
SARS-CoV-2 Infection and Associated Rates of Diabetic Ketoacidosis in a New York City Emergency Department
Emergency department (ED) visits resulting in a diagnosis for diabetic ketoacidosis (DKA) during early COVID-19 pandemic period of March to May 2020 were 70% higher than in the same period in 2019 in New York City (214 vs 106 diagnoses) according to an analysis of ED data extracted for routine quality review. By contrast, Total…
Persistent COVID-19 Symptoms Are Highly Prevalent 6 Months after Hospitalization: Results from a Large Prospective Cohort
Nearly 1 in 4 individuals hospitalized for COVID-19 had 3 or more persistent symptoms 6 months after hospital admission in a cohort study in France (n=1,137). Presence of 3 or more symptoms at 6 months was more common among women, those with 3 or more symptoms at admission, and those who were admitted to the…
SARS-CoV-2 Delta VOC in Scotland: Demographics, Risk of Hospital Admission, and Vaccine Effectiveness
SARS-CoV-2 infections caused by the B.1.617.2 (Delta) variant of concern were at increased risk of hospitalization (HR=1.9) compared to the B.1.1.7 (Alpha) variant after adjusting for demographics, temporal trends, and comorbidities, according to an analysis of 19,543 confirmed infections and 377 hospitalizations in Scotland from April 1 to June 6, 2021. Considering the whole population…
June 14, 2021
Comparison of Symptoms and RNA Levels in Children and Adults With SARS-CoV-2 Infection in the Community Setting
SARS-CoV-2 RNA levels, as determined by cycle threshold (Ct) values, were significantly higher in symptomatic compared to asymptomatic individuals, and no significant differences in RNA levels were detected between adults and children, according to results from a community-based cross-sectional study in King County, Washington. Among 555 SARS-CoV-2–positive participants, 47 of 123 children (38%) were asymptomatic…
International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries
A cohort study of children and adolescents (n=671) from France, Germany, Spain, Singapore, the UK, and the US found varying trends in COVID-19 hospitalizations and complications between countries, with hospitalizations in the cohort mirroring those of national-level pediatric hospitalization trends for most countries with available data. Laboratory values for 16 assays were analyzed, which indicated…
Risk Factors for Hospitalization Disease Severity and Mortality in Children and Adolescents with COVID-19 Results from a Nationwide German Registry
[Pre-print, not peer-reviewed] A cohort study of children and adolescents (n=1,501) who were admitted to the hospital between March 18, 2020 and April 30, 2021 in Germany and who tested positive for SARS-CoV-2 found that although approximately half of the cohort was not admitted to the hospital due to COVID-19, 72% had infection-related symptoms during…
June 11, 2021
Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2
A retrospective cohort study of persons with SARS-CoV-2 infection diagnosed between April and June 2020 in 7 US states identified 248 cases of multisystem inflammatory syndrome in children (MIS-C) in persons <21 years of age. The corresponding incidence of MIS-C was 5.1 per 100,000 person-months and 316 persons per 1,000,000 (0.0003%) SARS-CoV-2 infections. Incidence was…
First-Dose ChAdOx1 and BNT162b2 COVID-19 Vaccines and Thrombocytopenic, Thromboembolic and Hemorrhagic Events in Scotland
Compared to those who received one dose of the Pfizer-BioNTech COVID-19 vaccine, receipt of one dose of the Oxford-AstraZeneca vaccine was associated with a higher risk of idiopathic thrombocytopenic purpura (ITP), a blood disorder involving low platelet counts, during 0–27 days after vaccination (adjusted RR = 5.8), with an estimated incidence of 1.13 cases per 100,000…
June 10, 2021
Clinical and Molecular Characteristics of COVID-19 Patients with Persistent SARS-CoV-2 Infection
COVID-19 patients with extended viral shedding for >45 days (n=12) had lower levels of inflammatory cytokines/chemokines (IL-2, TNF, and LT-α) compared to an age- and sex-matched cohort of COVID-19 patients in whom viral shedding resolved within 21 days (n=39). Single-cell RNA sequencing from peripheral mononuclear blood cells from a subset of patients showed suppressed T…
June 9, 2021
Inflammatory Biomarkers in COVID-19-Associated Multisystem Inflammatory Syndrome in Children, Kawasaki Disease, and Macrophage Activation Syndrome: A Cohort Study
Pediatric patients diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C) (n=19) had higher median concentrations of interferon-induced monokines (CXCL9) compared to patients with Kawasaki Disease (n=9), another hyperinflammatory syndrome, in a cohort study in Ohio. Rodriguez-Smith et al. (June 9, 2021). Inflammatory Biomarkers in COVID-19-Associated Multisystem Inflammatory Syndrome in Children, Kawasaki Disease, and Macrophage Activation Syndrome:…
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