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Tag: clinical characteristics
February 5, 2021
Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults
A multicenter study of SARS-CoV-2 cases (n=5,544) confirmed by RT-PCR assay found no significant differences in viral concentration (as measured by Ct values) across different age groups. In particular, the children less than 5 years old did not display higher nasopharyngeal viral loads than older children or adults. Madera et al. (Feb 4, 2021). Nasopharyngeal…
February 4, 2021
COVID-19 Outcomes Among Persons Living With or Without Diagnosed HIV Infection in New York State
COVID-19 related outcomes were worse among persons living with diagnosed HIV than those without HIV in New York State between March to June 2020, according to population-level comparisons using matched data from HIV surveillance, COVID-19 laboratory-confirmed diagnoses, and hospitalization databases. Though persons living with and without diagnosed HIV had similar COVID-19 diagnosis rates, among persons…
Increased Hazard of Death in Community-Tested Cases of SARS-CoV-2 Variant of Concern 20201201
[Pre-print, not peer reviewed] The SARS-CoV-2 B.1.1.7 variant (first identified in the UK) was estimated to increase the risk of death by 30%, based on an analysis of a database of SARS-CoV-2 community test results in the UK. This dataset represents approximately 47% of all SARS-CoV-2 community tests and 7% of COVID-19 deaths in England…
February 3, 2021
Gastroenterology Manifestations and COVID-19 Outcomes: A Meta-Analysis of 25,252 Cohorts among the First and Second Waves
Twenty percent of COVID-19 patients presented with GI symptoms, according to a meta-analysis. In 125 studies included in the analysis, GI symptoms upon presentation to care included loss of appetite (20%), altered sense of taste or loss of taste (15%), diarrhea (13%), nausea (10%), and vomiting of blood (9%). Over 26% of patients had confirmed…
January 29, 2021
More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
[Pre-print, not peer-reviewed] Eighty percent (95%CI: 65% to 92%) of persons infected with SARS-CoV-2 developed one or more long-term symptoms, according to a systematic review and meta-analysis (n=47,910 patients) assessing long-term effects of COVID-19. Follow-up time of study participants ranged from 15 to 110 days post-viral infection. The age of the study participants ranged between…
The effect of SARS-CoV-2 variant B.1.1.7 on symptomatology re-infection and transmissibility
[Pre-print, not peer-reviewed] No association was found between the proportion of the UK SARS-CoV-2 variant B.1.1.7 in circulation and reported disease severity, according to data obtained from reporting of symptoms and test results via the COVID Symptom Study application. The authors controlled for both demographic characteristics (age, sex) and seasonal variables (temperature, humidity). No effects…
Outcomes of COVID-19 Among Hospitalized Health Care Workers in North America
Health care workers (HCWs) hospitalized with COVID-19 were less likely to require admission to an intensive care unit (aOR, 0.6; 95% CI, 0.3-0.9) and less likely to be admitted for 7 days or longer (aOR, 0.5; 95% CI, 0.3-0.8) when compared to matched non-healthcare workers in a retrospective, observational cohort involving 36 North American centers….
January 28, 2021
Impact of Race and Socioeconomic Status on Outcomes in Patients Hospitalized with COVID-19
A retrospective study of adults hospitalized for COVID-19 in Michigan (n=2038) found that patients from neighborhoods with median income in the lowest vs. highest quartile were more likely to require invasive mechanical ventilation (IMV) (25% vs 16%) and ICU admission (35% vs 20%). The median income of neighborhoods of Black patients was lower than neighborhoods…
Disease Severity, Pregnancy Outcomes and Maternal Deaths among Pregnant Patients with SARS-CoV-2 Infection in Washington State
Among a cohort of 240 pregnant patients with SARS-CoV-2 infection in Washington State, the COVID-19 hospitalization and case fatality rates were 3.5-fold and 13.6-fold higher, respectively, compared to rates among similarly-aged females and males with SARS-CoV-2 infections in Washington State. One in 11 developed severe or critical disease, 1 in 10 were hospitalized for COVID-19….
January 27, 2021
SARS-CoV-2 Infection in Pregnancy Is Associated with Robust Inflammatory Response at the Maternal-Fetal Interface
[Pre-print, not per-reviewed] A study of SARS-CoV-2 in pregnant women showed that in pregnant women with COVID-19, ACE2 is widely expressed in the placenta at term compared to low levels of expression in noninfected mothers. Despite the in vitro susceptibility of cytotrophoblasts (a type of placental cell) to SARS-CoV-2 infection, viral RNA was detected in…
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