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Tag: clinical characteristics
December 28, 2020
Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact
[pre-print; not peer-reviewed] In an international web-based survey of people with suspected or confirmed COVID-19 with illness lasting >28 days (n=3,762) identified 205 symptoms across 10 organ systems. In those who recovered in less than 90 days, the average number of symptoms peaked at week 2, as compared to a peak in month 2 among…
Risks of and Risk Factors for COVID-19 Disease in People with Diabetes: A Cohort Study of the Total Population of Scotland
A study of data from the total population of Scotland (n=5.5 million) found that people with diabetes had a substantially higher risk of dying from COVID-19 or requiring intensive care than the general population. After adjustment for age and sex, people living with Type 2 diabetes had 1.4 times the odds of dying or requiring…
December 23, 2020
Epidemiology of COVID-19 Infection in Young Children under Five Years: A Systematic Review and Meta-Analysis
A meta-analysis of laboratory confirmed COVID-19 in children under 5 years of age determined that children were frequently prescribed antibiotics and that the majority of the reported cases were children less than one year old. Bhuiyan et al. identified 65 studies of epidemiological and clinical characteristics of lab-confirmed COVID-19 infections in 1,214 children under age…
December 21, 2020
Increased Care at Discharge from COVID-19: The Association between Pre-Admission Frailty and Increased Care Needs after Hospital Discharge; a Multicentre European Observational Cohort Study
Among patients hospitalized with COVID-19, pre-admission frailty was strongly associated with the need for an increased level of care at discharge in a multicenter observational cohort study in Europe. Among 831 discharged patients (median age = 71 years, 44.4% women), the median length of hospital stay was 12 days, 23.2% had increased care needs at discharge. Vilches-Moraga…
December 18, 2020
The S1 Protein of SARS-CoV-2 Crosses the Blood–Brain Barrier in Mice
Using a mouse experimental model, intravenously injected SARS-CoV-2 spike protein subunit S1 was found to readily cross the blood-brain barrier (BBB) and enter the parenchymal brain space, and was also taken up by the lungs, spleen, kidney, and liver. Intranasally administered S1 also entered the brain, although at levels roughly ten times lower than after…
December 16, 2020
Neuroimaging Manifestations in Children with SARS-CoV-2 Infection: A Multinational, Multicentre Collaborative Study
A study of neuroimaging manifestations in 38 children from 8 countries identified acute- and delayed-phase SARS-CoV-2-related central nervous system abnormalities ranging from mild to severe. The most common imaging patterns observed were immune-mediated disseminated encephalomyelitis-like changes of the brain (n=16), myelitis (n=8), and neural enhancement (n=13). Splenial lesions (n=7) and myositis (n=4) were predominantly observed…
December 15, 2020
Impact of Population Growth and Aging on Estimates of Excess U.S. Deaths During the COVID-19 Pandemic, March to August 2020
Accounting for changes in the population age in the four-year period between 2015 and 2019 compared to the period between March and August of 2020 reduced estimates of excess deaths in the US from 301,400 deaths to 218,000 deaths, which substantially increased the contribution of COVID-19-related deaths (173,300 from March to August) to an excess…
COVID-19 Infections Among Healthcare Personnel in the United States Veterans Health Administration, March – August, 2020
Among 131,606 healthcare personnel (HCP) in the US Veterans Health Administration, 5,925 (4.5%) had positive SARS-CoV-2 PCR tests. HCP who were working in hospitals with >15% SARS-CoV-2 positivity among inpatients, as well as nursing staff, HCP who identify as Black or Hispanic, and veterans were at highest risk of SARS-CoV-2 infection. Male sex, age over…
Characteristics, Comorbidities and Survival Analysis of Young Adults Hospitalized with COVID-19 in New York City
In a cohort of young adults aged 18 to 35 years admitted to hospital with COVID-19 in New York City (n=395), 58% of patients had at least one major comorbidity. The mortality among those with at least one major comorbidity was 17% (40 of 229), compared to 9% (15 of 166) among those without a…
December 14, 2020
Readmission and Death After Initial Hospital Discharge Among Patients With COVID-19 in a Large Multihospital System
In a national cohort of 1775 patients discharged from Veterans Affairs medical centers after hospitalization for COVID-19 during March-July 2020, 479 (27%) were readmitted (20%) or died (9%) within 60 days of discharge. Rates of readmission or death by 60 days were significantly lower than those for matched survivors of pneumonia (26% vs. 32%) or…
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