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Tag: clinical characteristics
December 14, 2020
HIV Infection and COVID-19 Death: A Population-Based Cohort Analysis of UK Primary Care Data and Linked National Death Registrations within the OpenSAFELY Platform
A retrospective cohort study indicated that people with HIV in the UK (n = 27,480) had a higher risk of mortality from COVID-19 than those without HIV, after adjusting for age and sex (HR = 2.9). The risk remained high (HR = 2.6) after adjusting for index of multiple deprivation, smoking status, ethnicity, and obesity….
December 13, 2020
A Surge in Pediatric Coronavirus Disease 2019 Cases: The Experience of Texas Children’s Hospital from March to June 2020
A retrospective study of all children presenting to the Texas Children’s Hospital system who were tested for SARS-CoV-2 (16,554 unique patients), found that 1,215 (7%) patients tested positive, among whom 66% were Hispanic (representing 42% of the total number tested). Most children with detection of SARS-CoV-2 had uncomplicated illness courses, but 8% of children were…
December 10, 2020
Severity of COVID-19 in Children with Cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project
A retrospective and prospective observational study of all children in the UK under 16 diagnosed with cancer suggests that children with cancer do not appear to be at increased risk of severe SARS-CoV-2 infection compared to the general pediatric population. 54 cases were identified between March-July 2020 (3% estimated cumulative incidence); 5 (28%) were asymptomatic,…
December 8, 2020
Three-Month Follow-Up Study of Survivors of Coronavirus Disease 2019 after Discharge
In a follow-up study of 76 COVID-19 survivors, most participants reported symptoms including fever, sputum production, fatigue, diarrhea, and chest tightness on exertion three months after hospital discharge. Pulmonary high-resolution CT was normal for 82% of participants, though 42% had mild pulmonary function abnormalities. 13% of participants were seronegative for IgG and 72% were seronegative…
Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19
Being critically ill was an independent risk factor of longer PCR-confirmed viral positivity in a retrospective study of 2,142 COVID-19 patients in Wuhan, China. The observed median duration of PCR-confirmed viral positivity was 24 days among critically ill patients and 18 days among non-critically ill-patients, with 20% of samples remaining positive after 5 weeks. Seroconversion…
Evaluation of Rooming-in Practice for Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Italy
It may be possible to effectively mitigate the risk of mother-to-infant transmission of SARS-CoV-2 infection, based on findings from a multi-cohort study of mother-infant dyads (n=62 neonates, 61 mothers) in Italy that found no positive results among neonates 24 hours after birth despite a 95% breastfeeding rate. Infected mothers observed contact precautions such as handwashing…
December 7, 2020
Clinical Status and Lung Function 10 Weeks after Severe SARS-CoV-2 Infection
54% of 220 patients who recovered from COVID-19 had abnormal lung function 10 weeks after diagnosis in a study using chest CT, pulmonary function testing, and COVID-19 symptoms in Belgium. Restrictive pulmonary impairment was the most common type of lung function impairment observed (38%) and was associated with longer hospital stay (8 vs 6 days),…
December 4, 2020
Characteristics of Adults Aged 18–49 Years without Underlying Conditions Hospitalized with Laboratory-Confirmed COVID-19 in the United States, COVID-NET — March–August 2020
Analysis of data from a large, geographically diverse surveillance network of laboratory-confirmed COVID-19 hospitalizations in the US from March-August found that more than 1 in 5 adults (22%) ages 18-49 (n = 513) without underlying conditions who were hospitalized with COVID-19 experienced severe illness requiring ICU-level care. Additionally, 17% required invasive or noninvasive respiratory support,…
Patient Outcomes after Hospitalisation with COVID-19 and Implications for Follow-up: Results from a Prospective UK Cohort
A study evaluating patients in the UK (median age 60 years) who had been hospitalized with COVID-19 8-12 weeks after their admission found that most (74%) had persistent symptoms such as breathlessness (39%) and fatigue (39%), and experienced limitations in physical ability. Sixteen (59%) patients in the mild COVID-19 group reported ongoing symptoms compared with…
December 2, 2020
High Anal Swab Viral Load Predisposes Adverse Clinical Outcomes in Severe COVID-19 Patients
Higher viral load of SARS-CoV-2 RNA in anal swab samples was associated with severe COVID-19 outcomes including death (OR=1.4), ICU admission (OR=1.2) and need for invasive mechanical ventilation (OR=1.3) among a cohort of 188 hospitalized COVID-19 patients in China. The period from symptom onset to positive virus detection was also significantly shorter in non-survivors than…
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