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Tag: clinical characteristics
December 1, 2020
Increase in Hospital-Acquired Carbapenem-Resistant Acinetobacter Baumannii Infection and Colonization in an Acute Care Hospital During a Surge in COVID-19 Admissions — New Jersey, February–July 2020
A cluster of 34 patients infected with an antibiotic-resistant pathogen primarily associated with hospital-acquired infections was observed in a New Jersey hospital during a surge of COVID-19 hospitalizations in late May 2020. The cluster was linked to deviations in infection prevention and control practices due to pandemic-related resource challenges. Fewer incident cases were reported in…
Race/Ethnicity Among Children With COVID-19–Associated Multisystem Inflammatory Syndrome
Analysis of routine public health surveillance data from March to June 2020 identified an overrepresentation of Black children among those with COVID-19-associated multi-system inflammatory syndrome in children (MIS-C) in New York City (n=223). While Black children constitute 22% of the New York City population, 34% of patients were Black. Additionally, compared with white children, a…
Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review
In a systematic review (n=70 studies) including 1,457 pregnant women with COVID-19, 39 newborns tested positive for SARS-CoV-2. Among mothers, the most frequent comorbidities were obesity, hypertensive disorders, and gestational diabetes. Premature birth (n=64) and maternal death (n=15) were the most common adverse maternal outcomes, while intrauterine fetal distress (n=28) and intrauterine fetal death and…
IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Among 177 SARS-CoV-2 positive individuals from the UK, 15 (9%) did not seroconvert during the entire 60-day follow-up period, suggesting that a minority of infected persons may not develop detectable IgG against SARS-CoV-2. Persons who seroconverted were older compared to those who did not seroconvert (median age 66 vs 41 years) and were more likely…
November 25, 2020
Higher Viral Loads in Asymptomatic COVID-19 Patients Might Be the Invisible Part of the Iceberg
By comparing viral loads of asymptomatic and symptomatic laboratory-confirmed COVID-19 patients in samples obtained on admission to a hospital, researchers found that asymptomatic patients had higher SARSCoV-2 viral loads than symptomatic patients. Viral loads decreased with increasing disease severity. Viral loads of patients with at least one comorbidity (i.e., hypertension, diabetes, malignancy, chronic pulmonary disease)…
November 24, 2020
Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis
A systematic review and meta-analysis (n=47 studies) found that compared to healthy children, children with comorbidities had a 1.8-fold increase in risk for sever COVID-19. Underlying conditions and obesity were also associated with higher risk of COVID-19-associated mortality. Tsankov et al. (Nov 20, 2020). Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and…
Surviving COVID-19 After Hospital Discharge: Symptom, Functional, and Adverse Outcomes of Home Health Recipients
A retrospective observational cohort study of COVID-19 survivors admitted to home health care (HHC) post-hospitalization in New York City (n=1,409) found that after an average of 32 days in HHC, most patients experienced significant improvements in symptoms and function. 94% were discharged from HHC. Risk of rehospitalization or death (137 rehospitalizations, 11 deaths) was associated…
Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States
In a cohort of US pediatric patients (n=135,794; mean age=8.8), 5,374 (4%) tested positive for SARS-CoV-2, of whom 359 (7%) were hospitalized and 8 died (case fatality proportion = 0.2%). Despite lower rates of testing compared with White patients, participants of Black, Hispanic, and Asian race/ethnicity were more likely to have positive test results. Older…
November 23, 2020
Epidemiological and Clinical Characteristics of COVID-19 in Children: A Systematic Review and Meta-Analysis
A meta-analysis (n = 96 studies) of the clinical characteristics of SARS-CoV-2 in children (mean age 6.5 years) reported that 90% had household contact with an individual with SARS-CoV-2, 23% were asymptomatic, 27% had at least one comorbidity, and 29% had a co-infection, such as with mycoplasma or influenza. The pooled incubation period was 9.6…
Pregnant Women with Severe or Critical COVID-19 Have Increased Composite Morbidity Compared to Non-Pregnant Matched Controls
A case-control study of women hospitalized with severe or critical COVID-19 in New York City and Philadelphia reported that pregnant women (n=38) were more likely to experience severe outcomes, including death and need for intubation or ventilation, when compared to the non-pregnant (n=94) women (34% vs. 15%, aOR=4.6). Pregnant patients also experienced higher rates of…
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