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Tag: clinical characteristics
May 11, 2021
A New SARS-CoV-2 Variant Poorly Detected by RT-PCR on Nasopharyngeal Samples with High Lethality
[Pre-print, not peer-reviewed] Patients confirmed by viral sequencing to be infected with a novel SARS-CoV-2 variant first described in France (assigned lineage B.1.616) (n=34) were less likely to test positive on their first PCR test (15% vs 97%) and more likely to die within 28 days (44% vs 16%) compared to patients infected with variants…
May 10, 2021
Reverse-Transcribed SARS-CoV-2 RNA Can Integrate into the Genome of Cultured Human Cells and Can Be Expressed in Patient-Derived Tissues
A study using RNA sequencing found evidence to suggest that SARS-CoV-2 RNA may be able to integrate into human cell genomes in vitro, perhaps explaining the persistence of viral RNA among patients even after recovery from COVID-19. The authors found evidence that suggests viral–host chimeric transcripts are created via long interspersed nuclear elements, which reverse-transcribe…
Self-Reported Smell and Taste Recovery in Coronavirus Disease 2019 Patients: A One-Year Prospective Study
More than 20% of patients surveyed in Italy who recovered from mild-to-moderate symptomatic COVID-19 reported altered sense of smell or taste one year after initial symptom onset (prevalence = 57/286, 21%). 34 participants reported both smell and taste dysfunction, while 15 reported smell impairment alone and 5 taste disorder alone after 1 year. Of 187…
May 7, 2021
Emergency Department Visits for Emergent Conditions Among Older Adults During the COVID -19 Pandemic
A retrospective cohort study of non-COVID related emergency department visits among US adults found that visits for acute myocardial infarction (AMI), stroke, and sepsis declined precipitously during the early pandemic period and remained lower than pre-pandemic levels through the summer and fall, particularly among adults age ≥75. In contrast, visits for hip fractures and falls…
May 6, 2021
SARS-CoV-2 RNAemia Predicts Clinical Deterioration and Extrapulmonary Complications from COVID-19
In a sample of 191 COVID-19 patients presenting to the emergency department, viral RNA detected in blood (RNAemia) by digital PCR (dPCR) was associated with poor clinical outcomes. DCR was more sensitive than quantitative PCR (qPCR) in detecting RNAemia, or viral RNA in plasma (23% vs 1.4%). RNAemia was undetectable within 10 days of symptom…
SARS-CoV-2 Viral Load Kinetics in Symptomatic Children, Adolescents and Adults
Mean viral load (VL) was slightly lower at the time of SARS-CoV-2 infection diagnosis for children aged 0-13 years (6.2 log10 copies/mL) and adolescents aged 14-19 years (6.4 log10 copies/mL) compared to adults aged ≥20 years (6.7 log10 copies/mL) in a study in Switzerland (n=8,027). At time of diagnosis, the proportion of adults with VL…
May 5, 2021
Rapid Emergence and Epidemiologic Characteristics of the SARS-CoV-2 B.1.526 Variant — New York City, New York, January 1–April 5, 2021
The SARS-CoV-2 B.1.526 variant, a variant of concern/interest (VOC/VOI) first described in New York City (NYC), does not appear to lead to more severe disease, increased risk of infection after vaccination, or increased risk of reinfection according to preliminary analyses of infections with sequenced virus matched to epidemiologic characteristics in NYC from January to April…
SARS-CoV-2 Outbreak in Immune-Mediated Inflammatory Diseases: The Euro-COVIMID Multicentre Cross-Sectional Study
In a study including 3,028 patients in Europe with immune-mediated inflammatory disease, symptomatic COVID-19 occurred in 4% (n=122) and anti-SARS-CoV-2 antibodies were detected in 5% (n=166) of patients between June and December 2020. Symptomatic COVID-19 was associated with higher concentrations of C-reactive protein (OR=1.2) and higher numbers of disease flares (OR=1.3). Saadoun et al. (Apr 2021)….
Persistent Neuropsychiatric Symptoms after COVID-19 a Systematic Review and Meta-Analysis
[Pre-print, not peer-reviewed] In a systematic review and meta-analysis of neuropsychiatric symptoms in COVID-survivors (51 studies of 18,917 COVID-19 survivors), sleep disturbance was the most common neuropsychiatric symptom with a pooled prevalence of 27%, followed by fatigue (24%), objective cognitive impairment (also known as brain fog, 20%), anxiety (19%), and post-traumatic stress (16%). Mean duration…
May 4, 2021
Human Organoid Systems Reveal in Vitro Correlates of Fitness for SARS-CoV-2 B.1.1.7
[Pre-print, not peer-reviewed] In an in vitro human organoid system, the SARS-CoV-2 B.1.1.7 variant was shown to produce higher levels of infectious virus late in infection and higher replicative fitness in human airway, alveolar, and intestinal organoid models compared to the ancestral strain. Lamers et al. (May 3, 2021). Human Organoid Systems Reveal in Vitro Correlates…
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