Result for
Tag: pregnancy
April 7, 2021
Efficient Maternofetal Transplacental Transfer of Anti- SARS-CoV-2 Spike Antibodies after Antenatal SARS-CoV-2 BNT162b2 MRNA Vaccination
In a study of women who received the Pfizer (SARS-CoV-2 BNT162b2) vaccine, all 20 women and infants had detectable anti S- and anti-RBD-specific IgG. Anti-S and anti-RBD-specific IgG antibody levels in maternal sera were positively correlated to their respective concentrations in cord blood (correlation rho= 0.72; P<0.001 and correlation rho= 0.72; P <0.001, respectively) suggesting…
April 6, 2021
COVID-19 MRNA Vaccines Drive Differential Fc-Functional Profiles in Pregnant Lactating and Non-Pregnant Women
[Pre-print, not peer-reviewed] The antibody response induced by mRNA vaccines (Moderna and Pfizer-BioNTech) after the first dose was lower among pregnant (n=84) and lactating (n=31) women compared to non-pregnant age-matched controls (n=16), but after the second dose no significant differences were observed. Differences in antibody response after the first dose related to lower antibody titers…
March 16, 2021
Association of Preterm Birth Rate With COVID-19 Statewide Stay-at-Home Orders in Tennessee
The preterm birth rate in Tennessee was lower in 2020 during the stay-at-home order compared with the 5 preceding years. After adjusting for maternal age, education, race/ethnicity, diabetes, and hypertension the odds for preterm birth in 2020 was 14% lower compared with 2015 to 2019 (10.2% vs 11.3%). Harvey et al. (Mar 15, 2021). Association of…
March 9, 2021
COVID-19 Vaccine Response in Pregnant and Lactating Women a Cohort Study
[Pre-print, not peer-reviewed] The Pfizer-BioNTech and Moderna vaccines elicited similar immune responses among pregnant (n=84) and lactating (n=31) women compared to non-pregnant reproductive-age women (n=16). All vaccine-induced SARS-CoV-2-specific antibody titers were higher compared to titers from a group of pregnant women (n=37) that had SARS-CoV-2 infection 4-12 weeks prior. Vaccine-induced antibodies were detected in all…
March 3, 2021
SARS-CoV-2 Antibodies Detected in Human Breast Milk Post-Vaccination
[Pre-print, not peer-reviewed] Significantly elevated levels of SARS-CoV-2 specific IgG and IgA antibodies were observed in breast milk starting 7 days after the initial vaccine dose in a cohort study of six lactating women who had received both doses of either the Pfizer/BioNTech or Moderna vaccines. The authors note that the response following vaccination was…
March 2, 2021
Risk Factors for Illness Severity among Pregnant Women with Confirmed SARS-CoV-2 Infection – Surveillance for Emerging Threats to Mothers and Babies Network 20 State Local and Territorial Health Departments March 29 2020 -January 8 2021
[Pre-print, not peer-reviewed] Risk factors for developing moderate-to-severe COVID during pregnancy included age 30-39 years, Black/Non-Hispanic race/ethnicity, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, cardiovascular disease, pre-gestational diabetes or gestational diabetes. The study was conducted by the CDC from March 2020 to January 2021 and included 5,963 pregnant women with laboratory confirmed SARS-CoV-2…
February 23, 2021
What Is Driving the Decreased Incidence of Preterm Birth during the COVID-19 Pandemic?
A retrospective cohort study of over 17,687 singleton deliveries prior to the COVID-19 pandemic (January 2018 to January 2020) and over 5,396 singleton deliveries during the pandemic (April 2020 to October 2020) at a single tertiary center in Pennsylvania found a small but statistically significant decrease in overall preterm birth (11% vs 10%). Both spontaneous…
February 22, 2021
Higher SARS-CoV-2 Infection Rate in Pregnant Patients
The SARS-CoV-2 infection rate among pregnant individuals in Washington State (13.9/1,000 deliveries) was 70% higher than the rate among similarly-aged adults, which was not completely explained by universal screening at delivery. 240 pregnant patients with PCR-confirmed SARS-CoV-2 infection were identified from March 1-June 3, 2020, and the proportion of cases in pregnancy among most ethnic…
February 16, 2021
Lack of Changes in Preterm Delivery and Stillbirths during COVID-19 Lockdown in a European Region
The proportion of preterm deliveries (< 37 weeks) and stillbirths was similar in the Castilla-y-Leon region in Spain during the COVID-19 lockdown and de-escalation periods (March 15 to June 21, 2020) compared to previous time periods. The proportion of preterm deliveries during the lockdown was 6.5%, compared to 6.6% during the whole pre-lockdown period (January…
Longitudinal Analysis of Antibody Response Following SARS-CoV-2 Infection in Pregnancy: From the First Trimester to Delivery
In a cohort of 17 SARS-CoV-2 PCR-positive pregnant women followed from the end of the first trimester to delivery, IgG non-neutralizing antibodies (nNAbs) were detected in 71% (12 of 17), while neutralizing antibodies (NAbs) were detected in 53% of individuals (9 of the 12 who seroconverted with IgG nNAbs). Levels of NAbs remained stable throughout…
Previous page Next page