Alliance for Pandemic Preparedness

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Tag: re-infection

June 1, 2021

Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy

Individuals with known prior SARS-CoV-2 infection had a 93% lower incidence of SARS-CoV-2 infection in the following year, according to a cohort study in Italy from February 2020 to February 2021. During a mean follow-up of 280 days, 5 reinfections occurred in 1,579 patients with a prior positive PCR test (mean interval between infections >230…

Prior COVID-19 Protects against Reinfection, Even in the Absence of Detectable Antibodies

Risk of SARS-CoV-2 infection in the UK between August 2020 and January 2021 was 80% lower among individuals with lab-confirmed infection but later testing antibody-negative (i.e. RNA-positive antibody-negative) compared to individuals who did not have infection (no test or RNA-negative and antibody-negative) during March to July 2020, according to an analysis of datasets obtained from…

May 7, 2021

SARS-CoV-2 Infection and Reinfection in a Seroepidemiological  Workplace Cohort in the United States

 [Pre-print, not peer-reviewed] A prospective cohort study of SpaceX employees (N=4,111) found a 91% lower odds of SARS-CoV-2 reinfection over 6 months of follow-up among participants with  detectable SARS-CoV-2 antibodies at baseline. The study authors adjusted for underlying health  conditions and increased risk of exposure as potential confounders. The results suggest that previous infection may…

May 5, 2021

Evaluation of Potential COVID-19 Recurrence in Patients with Late Repeat Positive SARS-CoV-2 Testing

Among 23,176 patients with a positive SARS-CoV-2 in Utah between March and July 2020, 4 of 1,301 patients with at least one additional PCR test ≥60 days after the initial positive test were identified to have probable reinfection and 6 additional patients had possible reinfection. Reinfection was assessed using combined clinical and RT-PCR cycle threshold…

May 4, 2021

SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy

Incidence of SARS-CoV-2 infection was 95% lower among persons with prior SARS-CoV-2 infection, indicated by seropositivity, in a cohort study in Qatar. In the study, 129 of 43,044 seropositive persons (0.3%) followed for a median of 16 weeks had at least one positive PCR test supported by evidence of reinfection at least 14 days after…

April 21, 2021

The Risk of Symptomatic Reinfection during the Second COVID-19 Wave in Individuals Previously Exposed to SARS-CoV-2

[Pre-print, not peer-reviewed] In a cohort study in Italy, the adjusted odds ratio for developing symptomatic SARS-CoV-2 infection with SARS-CoV-2 IgG antibodies was 0.05 in the six months following antibody measurement when compared to individuals who were seronegative. The cumulative incidence of laboratory-confirmed, symptomatic infections among IgG-negative and IgG positive cohorts was 2.7% in seronegative…