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Tag: sequelae
April 21, 2021
Post-COVID-19 Syndrome in Outpatients a Cohort Study
[Pre-print, not peer-reviewed] In a prospective cohort of symptomatic outpatients undergoing SARS-CoV-2 PCR testing in Switzerland (n= 507), 53% of patients with SARS-CoV-2 infection reported persistent symptoms between 3 and 10 months after diagnosis compared to 37% of patients who tested negative. About 20% of patients who tested positive consulted a physician for persistent symptoms,…
April 20, 2021
Symptoms, Pulmonary Function and Functional Capacity Four Months after COVID-19
Fatigue and shortness of breath with exertion were present four months after infection in approximately 70% of COVID-19 survivors, according to a prospective study of hospitalized COVID-19 patients in Ottawa, Canada (n=25). Among non-hospitalized survivors (n=38), fatigue and exertional breathlessness persisted in 71% and 55%, respectively. At follow-up, forced vital capacity, total lung capacity, peak…
April 15, 2021
Vaccination Boosts Protective Responses and Counters SARS-CoV-2-Induced Pathogenic Memory B Cells
[Pre-print, not peer-reviewed] SARS-CoV-2 specific B cells isolated from individuals who had recovered from SARS-CoV-2 infection appeared similar to B cells isolated previously described in individuals with chronic infections or inflammation (IgD negative, CD27 negative), according to a longitudinal study of convalescent individuals (n=22). After vaccination, the frequency of IgD/CD27 negative cells (“double negative”) decreased….
April 14, 2021
Post-Acute COVID-19 Sequelae in Cases Managed in the Community or Hospital in the UK a Population Based Study
[Pre-print, not peer-reviewed] A population-based study of post-COVID-19 sequelae in England found that hospitalized patients had higher rates of 13 of 26 symptoms assessed and 11 of 19 diseases, and had higher healthcare utilization, than those who had not been hospitalized. Comparing symptom rates (per 100,000 person-weeks), hospitalized patients experienced more breathlessness (536 vs. 87),…
April 8, 2021
Incidence and Severity of Depression Among Recovered African Americans with COVID-19-Associated Respiratory Failure
44% (32 of 73) of African American patients who were admitted to the ICU and underwent invasive mechanical ventilation for COVID-19 were diagnosed with major depressive disorder (MMD) within 90 days of discharge. Patients were identified during depression screening following discharge from a hospital in Atlanta, Georgia. MDD was more frequently diagnosed in women than…
April 1, 2021
Post-Acute Sequelae of COVID-19 in a Non-Hospitalized Cohort Results from the Arizona CoVHORT
[Pre-print, not peer-reviewed] 69% of non-hospitalized individuals infected with SARS-CoV-2 in Arizona (n=303) experienced post-acute sequelae of SARS-CoV-2 infection (PASC, experiencing at least one symptom for ≥30 days). In a subset of the cohort (n=157) followed for >60 days, prevalence of PASC was 77%. Participants were followed for a median of 61 days; during follow-up,…
Post-Covid Syndrome in Individuals Admitted to Hospital with Covid-19: Retrospective Cohort Study
Individuals discharged following hospitalization for COVID-19 were 4 and 8 times more likely to be readmitted and to die compared to controls matched for personal and clinical characteristics. In this retrospective cohort study, 47,780 patients with COVID-19 discharged by August 2020 were matched to a pool of about 50 million people in England. Nearly a…
March 23, 2021
Radiological and Functional Lung Sequelae of COVID-19: A Systematic Review and Meta-Analysis
A systematic review of PubMed and Embase to investigate characteristics of lung sequelae in COVID-19 patients found that about half of COVID-19 patients still had residual abnormalities on chest computerized tomography (CT) and pulmonary function tests (PFTs) at about 3 months after hospital discharge. Residual CT abnormalities were present in 55.7% (95% CI 41.2-70.1) of…
March 18, 2021
Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19
51% of COVID-19 survivors reported at least 1 new-onset symptom at four months after hospitalization that was not previously present in a cohort study (n=478) in France. New-onset symptoms included fatigue (31%), cognitive symptoms (21%), and shortness of breath (16%). In a subset of patients with further evaluations (n=177, including 97 of 142 former ICU…
March 9, 2021
Persistence of Symptoms up to 10 Months Following Acute COVID-19 Illness
[Pre-print, not peer-reviewed] Among US individuals with a history of symptomatic COVID-19 (n=6,211) participating in a 10-wave survey between June 2020 to January 2021, 80% reported recovering within less than 2 months and 8% reported experiencing symptoms for 2 months or more. 3% and 2% reported being symptomatic for ≥4 months and ≥6 months, respectively….
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