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Tag: testing
September 21, 2020
Clinical Impact, Costs, and Cost-Effectiveness of Expanded SARS-CoV-2 Testing in Massachusetts
Neilan et al. conducted a modeling study to examine testing strategies for SARS-CoV-2 under scenarios of different transmission intensity. In a scenario where transmission is slowing (Re=0.9), testing the entire population monthly and testing people with COVID-19 symptoms as needed would reduce infections by 63% and mortality by 44% compared to testing only patients with…
Value of Swab Types and Collection Time on SARS-COV-2 Detection Using RT-PCR Assay
Samples collected on swabs before washing in the morning had higher detection rates of SARS-CoV-2 than samples collected during afternoon on the same day in a study (n=48) completed in Hubei, China. Nasopharyngeal swab detection was 65% in the morning vs. 43% in afternoon, and oropharyngeal swab detection was 23% in morning vs. 8% in…
September 18, 2020
Evaluation of Performance of Two SARS-CoV-2 Rapid IgM-IgG Combined Antibody Tests on Capillary Whole Blood Samples from the Fingertip
Two point-of-care serology tests utilizing capillary whole blood samples from a finger prick (COVID-PRESTO and COVID-DUO) had 100% sensitivity and 100% specificity for SARS-CoV-2 antibodies when administered at least 15 days after symptom onset. Sensitivity was calculated among patients who tested positive by PCR (n=238) and specificity was calculated among patients negative by PCR (n=143)….
Assessing a Novel, Lab-Free, Point-of-Care Test for SARS-CoV-2 (CovidNudge): A Diagnostic Accuracy Study
The CovidNudge test, a rapid point-of-care real-time PCR test requiring no laboratory handling or sample pre-processing, had an overall sensitivity and specificity of 94% (95% CI: 86-98%) and 100% (95% CI: 99-100%), respectively, when compared against standard laboratory PCR in paired samples (n=386) from health workers and hospitalized patients. Gibani et al. (Sept 17, 2020)….
September 17, 2020
Preventing COVID-19 Outbreaks in Long-Term Care Facilities Through Preemptive Testing of Residents and Staff Members — Fulton County, Georgia, March–May 2020
There was a considerably higher proportion of positive SARS-CoV-2 test results among residents and staff in long-term care facilities when testing was conducted in response to an initial confirmed case of COVID-19 compared to preventive testing done before cases were detected. In Fulton County, Georgia, testing in response to an initial case in long-term care…
Serial Testing for SARS-CoV-2 and Virus Whole Genome Sequencing Inform Infection Risk at Two Skilled Nursing Facilities with COVID-19 Outbreaks — Minnesota, April–June 2020
During April–June 2020, serial facility-wide testing at two Minnesota skilled nursing facilities (SNFs) identified COVID-19 cases among 64% of residents (N=259) and 33% of health care personnel (N=341). Genetic sequencing found facility-specific clustering of viral genomes from healthcare professionals’ and residents’ specimens, suggesting intra-facility transmission. Taylor et al. (Sept 18, 2020). Serial Testing for SARS-CoV-2…
Change in Antibodies to SARS-CoV-2 Over 60 Days Among Health Care Personnel in Nashville, Tennessee
Anti-SARS-CoV-2 antibody levels declined over 60 days among all 19 health care personnel in Tennessee who had anti–SARS-CoV-2 antibodies at baseline. In 11 (58%), antibody levels declined substantially enough that they tested negative at 60 days, while 8 (42%) remained seropositive after 60 days. The authors conclude that cross-sectional seroprevalence studies may underestimate rates of…
Self-Collected Saline Gargle Samples as an Alternative to Healthcare Worker Collected Nasopharyngeal Swabs for COVID-19 Diagnosis in Outpatients
[Pre-print, not peer reviewed] Self-collected saline mouth rinse/gargle samples and saliva samples had a sensitivity of 98% (39/40) and 79% (26/33), respectively, compared to healthcare worker (HCW)-collected nasopharyngeal swab samples among 40 people with SARS-CoV-2. Both types of self-collected samples showed stable viral RNA detection after 2 days of storage at room temperature and demonstrated…
Prolonged SARS-CoV-2 Detection and Reversed RT-PCR Results in Mild or Asymptomatic Patients
Many people with mild or asymptomatic COVID-19 (n=300) had prolonged SARS-CoV-2 RNA positivity with intermittent negative tests in a study in Korea. 23% had SARS-CoV-2 detected more than 3 weeks after the initial positive RT-PCR test, and 14% had positive results for more than 4 weeks. Overall, 37% (152/405) of negative results were positive or…
September 15, 2020
SARS-CoV-2 Recurrent RNA Positivity after Recovering from Coronavirus Disease 2019 (COVID-19): A Meta-Analysis
A systematic review found that the estimated cumulative proportion of recurrent RNA positivity in recovered COVID-19 patients was 12% (95% CI: 12-13%), ranging from 7-23% across studies and with follow-up testing between 1 and 60 days. Mattiuzzi et al. (Sept 7, 2020). SARS-CoV-2 Recurrent RNA Positivity after Recovering from Coronavirus Disease 2019 (COVID-19): A Meta-Analysis….
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