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Tag: testing
February 13, 2021
Comparison of Sixteen Serological SARS-CoV-2 Immunoassays in Sixteen Clinical Laboratories
The diagnostic accuracy of 16 antibody assays was assessed with 150 samples from people with asymptomatic, mild, or moderate COVID-19. Although confidence intervals overlapped for several assays, sensitivities in descending order were: Wantai/ELISA total-Ab (97%), CUH-NOVO/in-house ELISA total-Ab (96%), Ortho/Vitros total-Ab (95%), YHLO/iFlash-IgG (94%), Ortho/Vitros-IgG (93%), Siemens/Atellica total-Ab (93%), Roche/Elecsys total-Ab (93%), Abbott/Architect-IgG (90%), Abbott/Alinity-IgG…
Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Screening Using Reverse Transcriptase-Quantitative Polymerase Chain Reaction or CRISPR-Based Assays in Asymptomatic College Students
Rauch et al. concluded that CRISPR-based methods appear to offer reliable SARS-CoV-2 screening based on testing 1,808 asymptomatic college students with both RT-qPCR and CRISPR-based assays. Of the nine samples that tested positive by RT-PCR, eight were also positive by CRISPR-based assays, which are cheaper to run and use lab-generated or off-the-shelf reagents, potentially alleviating…
February 11, 2021
Information About COVID-19 Testing on College Websites in the New York City Metropolitan Area
A cross-sectional study of 150 community colleges and universities in the New York City metropolitan area found that institutes of higher education did not provide information on COVID-19 uniformly or comprehensively. 83% of institutions reported testing data to the campus community, of which 63% released the data bi-weekly. Larger institutions (>10,000 students) were more likely…
Modeling Effectiveness of Testing Strategies to Prevent COVID-19 in Nursing Homes —United States, 2020
A model calibrated to US nursing homes suggests that 54% SARS-CoV-2 infections could be prevented by instituting weekly testing with a 2-day turnaround for all staff and residents immediately following detection of an index case (i.e. outbreak testing). Increasing the frequency of testing and reducing the turnaround to daily testing with immediate results could further…
Symptoms and Laboratory Manifestations of Mild COVID-19 in a Repatriated Cruise Ship Cohort
Among 49 passengers traveling from Uruguay to Australia on a cruise ship with high COVID-19 incidence in April 2020, 42% were asymptomatic and only 15% of symptomatic cases reported fever. Serial respiratory and rectal swabs were positive for 10% and 5% of participants, respectively, after a median of 3 weeks post-symptom onset. The authors suggest…
SARS-CoV-2 Antibody Prevalence in England Following the First Peak of the Pandemic
A large serosurvey in England (REACT-2 Study) estimated the nationwide seroprevalence of SARS-CoV-2 to be 6%, corresponding to an estimated 3.4 million people with prior infection. Seroprevalence was determined from a representative cohort of over 100,000 adults (>18 years old). Prevalence was 2- to 3-fold higher among healthcare workers compared with non-essential workers, and higher…
Citywide Serosurveillance of the Initial SARS-CoV-2 Outbreak in San Francisco
[Pre-print, not peer reviewed] SARS-CoV-2 serosurveillance using remnant samples from routine blood draws in two major hospital networks in San Francisco estimated a seroprevalence of 4.2% in the period between March and June 2020. Seroprevalence was higher among those who were uninsured; individuals identifying as Hispanic, Black, or African; males; and individuals who experience homelessness….
Detection Of Genomic Variants Of SARS-CoV-2 Circulating In Wastewater By High-Throughput Sequencing
[Pre-print, not peer reviewed] Analysis of 40 Spanish wastewater samples obtained between April and October 2020 identified three variants with mutations in the spike protein not previously detected elsewhere and 7 non-synonymous spike protein mutations not previously detected in Spain. Three of these 7 mutations have been found at low frequencies in sequencing of genomes…
Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19
SARS-CoV-2 RNA was not detected by RT-qPCR in breast milk samples (n=37) collected from 18 women following COVID-19 diagnosis. Breast milk was collected on average 12.0 +/- 8.9 days after onset of signs and/or symptoms. In contrast, 76% and 80% of samples contained anti-SARS-CoV-2 IgA and IgG, respectively, and 62% of samples neutralized SARS-CoV-2 in…
February 10, 2021
Disparities in SARS-CoV-2 Testing in Massachusetts During the COVID-19 Pandemic
A cohort study of SARS-CoV-2 testing intensity (defined as number of weekly tests per 100,000 people) and epidemic intensity (defined as weekly test positivity) in Massachusetts from May 27 to October 14, 2020 showed that testing resources were disproportionately allocated to more affluent communities. In a multivariable model, the relative testing gap increased by 9%…
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