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Tag: vaccination
April 26, 2021
Interim Findings from First-Dose Mass COVID-19 Vaccination Roll-out and COVID-19 Hospital Admissions in Scotland: A National Prospective Cohort Study
Between December 8, 2020, and February 22, 2021, receipt of the first dose of the Pfizer-BioNTech vaccine in Scotland was associated with a vaccine effectiveness of 91% for reduced COVID-19 hospital admission at 28–34 days post-vaccination, and 88% for the Oxford-AstraZeneca vaccine. Over the study period, a total of 1,331,993 individuals who had not previously…
Cerebral Venous Sinus Thrombosis (CVST) Is Not Significantly Linked to COVID-19 Vaccines or Non-COVID Vaccines in a Large Multi-State US Health System
[Pre-print, not peer-reviewed] Cerebral venous sinus thrombosis (CVST), which occurs when a blood clot prevents blood from properly flowing out of the brain, was rare and not significantly associated with COVID-19 vaccines in a study conducted among individuals who received the Pfizer-BioNTech (n = 94,818 doses), Moderna (n = 36,350 doses) and Johnson & Johnson…
BNT162b2 Vaccination Effectively Prevents the Rapid Rise of SARS-CoV-2 Variant B.1.1.7 in High Risk Populations in Israel
The SARS-CoV-2 B.1.1.7 variant was 45% more transmissible than the original strain in Israel, and was identified in more than 90% of positive tests by February 4th, according to an analysis of nearly 300,000 RT-PCR samples collected between December 6, 2020 and February 10, 2021. The authors note that surveillance programs and prioritized vaccination, which…
First Dose of BNT162b2 MRNA Vaccine in a Health Care Worker Cohort Is Associated with Reduced Symptomatic and Asymptomatic SARS-CoV-2 Infection
Among healthcare workers at a hospital in the UK, increased coverage (8.3% to 82.5%) of at least one dose of the Pfizer-BioNTech vaccination was associated with significant reductions in symptomatic and asymptomatic cases of SARS-CoV-2. There was a significant negative correlation between cumulative vaccination and PCR positive cases (R = -0.91), along with a marked…
COVID-19 Vaccine Coverage in Health-Care Workers in England and Effectiveness of BNT162b2 MRNA Vaccine against Infection (SIREN): A Prospective, Multicentre, Cohort Study
The Pfizer-BioNTech vaccine showed 70% effectiveness against SARS-CoV-2 infection 21 days after the first dose, and 85% effectiveness 7 days after two doses among staff working in publicly-funded hospitals in the UK. Participants were followed for two months, for a total of 1,106,905 person-days. During follow-up, 977 new infections occurred among unvaccinated individuals (14 per…
Maternal and Child Outcomes Reported by Breastfeeding Women Following MRNA COVID-19 Vaccination
[Pre-print, not peer-reviewed] Among individuals who were breastfeeding and received an mRNA SARS-CoV-2 vaccine (n = 180, 71% Pfizer-BioNTech, 29% Moderna), >85% reported experiencing side effects following either dose. Those who received the Moderna vaccine were significantly more likely to report systemic side effects after the second dose like fever, chills, and vomiting, in addition…
April 23, 2021
Addressing Racial/ethnic Disparities in the COVID-19 Vaccination Campaign
[Pre-print, not peer-reviewed] An analysis of state-level, race-stratified COVID-19 vaccination data found that Black and Hispanic adults have received proportionally lower levels of vaccinations compared to white adults. Across all states, adjusted for eligible population size, vaccine coverage among Black and Hispanic adults was 27% compared to 44% in white adults as of March 31,…
Previous COVID-19 Infection but Not Long-COVID Is Associated with Increased Adverse Events Following BNT162b2Pfizer Vaccination
[Pre-print, not peer-reviewed] A study of UK healthcare workers (N=974) vaccinated with the Pfizer-BioNTech vaccine found that prior SARS-CoV-2 infection, but not long-COVID, was associated with a higher incidence of self-reported adverse events following the first vaccine dose. Those with a self-reported prior SARS-CoV-2 infection were more likely to report ≥1 moderate-to-severe symptom with onset…
April 21, 2021
COVID-19 Dynamics after a National Immunization Program in Israel
Two months after the initiation of the SARS-CoV-2 vaccination (Pfizer-BioNTech) campaign in Israel, there were declines in the number of cases (by 77%), percentage of positive tests (by 45%), number of hospitalizations (by 68%), and number of severe hospitalizations (by 67%) compared to peak values. The authors suggest that these results are likely driven by…
April 19, 2021
COVID-19 Vaccination Preparedness Policies in U.S. Hospitals
A survey of US infectious disease physicians conducted between December 10, 2020 and January 2, 2021 found that 571 respondents (95%) reported that their facilities had a plan for determining which healthcare personnel (HCP) would be vaccinated first, with most prioritizing by unit (n = 226, 40%), job title or type of work (n =…
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