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Tag: vaccines
February 13, 2021
Safety and Efficacy of the ChAdOx1 NCoV-19 (AZD1222) Covid-19 Vaccine against the B.1.351 Variant in South Africa
[pre-print; not peer-reviewed] A randomized trial conducted in South Africa found the incidence of COVID-19 >14 days after the second dose of the AstraZeneca-Oxford SARS-CoV-2 vaccine was 93.6 per 1,000 person-years (23 cases among 717 participants) in the vaccine group and 73.1 per 1,000 person-years (19 cases among 750 participants) in the placebo group, yielding…
Impact of Age, Ethnicity, Sex and Prior Infection Status on Immunogenicity Following a Single Dose of the BNT162b2 MRNA COVID-19 Vaccine: Real-World Evidence from Healthcare Workers, Israel, December 2020 to January 2021
A single dose of the Pfizer SARS-CoV-2 vaccine produced detectable anti-SARS-CoV-2 spike IgG antibodies 21 days after vaccination in 92% (n=475) of a cohort of healthcare workers in Israel, including in 92% (n=458) of people who had no history of COVID-19 infection. The 39 healthcare workers who did not respond to the first dose were…
February 11, 2021
Impact of COVID-19 Vaccination Program on Healthcare Worker Infections in an Academic Hospital
An academic hospital in Virginia reported a 25% decrease in health care worker (HCW) SARS-CoV-2 infections 6 days after beginning employee immunizations. Vaccines included both the Pfizer vaccine initiated on December 12, 2020 and the Moderna vaccine initiated on December 28, 2020. After achieving 60% vaccination coverage of the 1st dose, infections decreased by 50%….
February 10, 2021
Coronavirus Disease 2019 Vaccine Hesitancy among Children’s Hospital Staff: A Single-Center Survey
Among children’s hospital clinical and non-clinical staff (n=4,448) who responded to an electronic survey on the first day of the hospital’s administration of the Pfizer/BioNTech COVID-19 vaccine, the majority of respondents (60%) reported they would definitely receive the vaccine, and 9% had already received the vaccine. Vaccine hesitancy was reported among 19% of respondents, and…
COVID-19 Vaccine Acceptability among U.S. Firefighters and Emergency Medical Services Workers
Findings from a cross-sectional survey conducted in October 2020 among firefighters and EMTs (n=3,169) showed that 48% of respondents expressed high acceptability of a future COVID-19 vaccine, while 24% reported that they were unsure and 28% reported low acceptability. Groups with greater odds of reporting low acceptability (relative to the high acceptability group) included individuals…
Neutralization of SARS-CoV-2 Spike 69/70 Deletion, E484K and N501Y Variants by BNT162b2 Vaccine-Elicited Sera
Human sera from 20 participants who received both doses of the Pfizer/BioNTech vaccine showed equivalent neutralization titers (with differences of four-fold or less) between wild type and variants strains of SARS-CoV-2 viruses that were engineered to contain spike proteins from recently emerged variants. The combinations of mutations included N501Y (present in variants emerging from the…
February 9, 2021
COVID-19 Vaccination Intent, Perceptions, and Reasons for Not Vaccinating Among Groups Prioritized for Early Vaccination — United States, September and December 2020
Among US adults in priority groups, intent to receive COVID-19 vaccination increased from 39% in September 2020 to 49% in December 2020, according to two separate nationally representative cross-sectional surveys conducted by the CDC (n=3,541 in September and n=2,033 in December). While vaccination non-intent also decreased from 38% to 32%, younger adults, women, non-Hispanic Black…
Decreased SARS-CoV-2 Viral Load Following Vaccination
[Pre-print, not peer-reviewed] SARS-CoV-2 PCR positive samples collected from persons 12-28 days after receiving the first dose of the Pfizer vaccine had lower viral load concentrations compared to positive samples from non-vaccinated demographically matched persons (based on cycle threshold (Ct) counts to detect genes associated with SARS-CoV-2). The increase in Ct count corresponded to a…
February 8, 2021
Prioritizing Allocation of COVID-19 Vaccines Based on Social Contacts Increases Vaccination Effectiveness
[Pre-print, not peer-reviewed] Using an agent-based modeling approach integrating social contact networks in Virginia, spatiotemporal surveillance data on COVID-19 cases, and models of within- and between-host disease dynamics, Chen et al. showed that vaccine allocation based on the number of an individuals’ social contacts and total social proximity time was significantly more effective at reducing the number…
Infection and MRNA-1273 Vaccine Antibodies Neutralize SARS-CoV-2 UK Variant
[Pre-print, not peer-reviewed] A study using a live virus neutralization assay to compare potency of neutralization between people who had been infected with SARS-CoV-2 or had received the Moderna COVID-19 vaccine against a panel of SARS-CoV-2 variants showed that antibodies in sera from both groups were effective at neutralizing the B.1.1.7 variant. Serum neutralization titers…
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