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Tag: vaccines
December 8, 2020
Safety and Efficacy of the ChAdOx1 NCoV-19 Vaccine (AZD1222) against SARS-CoV-2: An Interim Analysis of Four Randomised Controlled Trials in Brazil, South Africa, and the UK
An interim analysis of two of the four ongoing phase 2/3 trials for the Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (n=7,548 in UK trial, n=4,088 in Brazil trial) showed a vaccine efficacy of 62.1% (95%CI 41.0-75.7%) among participants who received the planned two standard doses (27 COVID-19 cases among 4,440 in the vaccine group…
December 7, 2020
While Studies on Covid‐19 Vaccine Is Ongoing; the Public’s Thoughts and Attitudes to the Future Covid‐19 Vaccine
Survey results from 759 adults in Turkey indicated that 49.7% of respondents said they would get a SARS-CoV-2 vaccine, and 38.4% said they would have their children vaccinated. Respondents cited the importance of protecting themselves, their children, and the people around them as the most common reasons they would get a vaccine. Common concerns about…
December 4, 2020
Durability of Responses after SARS-CoV-2 MRNA-1273 Vaccination
Immunogenicity data from 24 participants obtained at 119 days after initial vaccination (90 days after second vaccination) with the mRNA-1273 SARS-CoV-2 vaccine (Moderna) indicated that the vaccine produced high levels of binding and neutralizing antibodies that declined slightly over time, but remained elevated in all participants 3 months after the booster vaccination. Serum neutralizing antibodies…
December 3, 2020
International Estimates of Intended Uptake and Refusal of COVID-19 Vaccines A Rapid Systematic Review and Meta-Analysis of Large Nationally Representative Samples
[Pre-print, not peer reviewed] A systematic review and meta-analysis of 28 nationally representative samples from 13 countries (n=58,656) found that although a majority of people intend to be vaccinated for COVID-19, an increasing percentage of people are intending to refuse vaccination. Estimates of people intending to refuse vaccination rose from 12% in March-May to 20%…
Predicted Cellular Immunity Population Coverage Gaps for SARS-CoV-2 Subunit Vaccines and Their Augmentation by Compact Peptide Sets
Using machine learning predictions and clinical data from convalescent COVID-19 patients, Liu et al. developed a vaccine design that would incorporate enough pathogen components to elicit an immune response across a diverse population of people. The study also indicates that current vaccine candidates, which are largely based only on the SARS-CoV-2 spike protein and receptor…
The Advisory Committee on Immunization Practices’ Interim Recommendation for Allocating Initial Supplies of COVID-19 Vaccine — United States, 2020
Interim guidance from The Advisory Committee on Immunization Practices (ACIP) recommends that both 1) health care personnel and 2) residents of long-term care facilities (LTCF) be offered a COVID-19 vaccine in the initial phase of the vaccination program. As of December 1, approximately 245,000 COVID-19 cases and 858 COVID-19-associated deaths had been reported among U.S….
December 1, 2020
Risk Exposures Risk Perceptions Negative Attitudes toward General Vaccination and COVID-19 Vaccine Acceptance among College Students in South Carolina
[Pre-print, not peer reviewed] Online survey data from 1,062 college students in South Carolina suggest that perceived severity and fear of COVID-19 were positively associated with COVID-19 vaccine acceptance, while a higher level of risk exposures and negative attitude toward vaccines in general were associated with low COVID-19 vaccine acceptance. Qiao et al. (Nov 30,…
Willingness to Vaccinate against COVID-19 in the US Longitudinal Evidence from a Nationally Representative Sample of Adults from April-October 2020
[Pre-print, not peer reviewed] Willingness to receive a SARS-CoV-2 vaccine declined from 71% in April to 54% in October among US adults, according to longitudinal data from a nationally representative sample (n=7,547). The decline was primarily driven by an increase in participants undecided about being vaccinated and unwilling to be vaccinated. Participants without a college…
November 24, 2020
Willingness to Get the COVID-19 Vaccine with and without Emergency Use Authorization
A quota-sampled online survey of 788 US adults found that 60% of participants were either definitely willing or probably willing to receive a future COVID-19 vaccine and 25% were either definitely willing or probably willing to receive the vaccine if it were approved under an Emergency Use Authorization (EUA). Significant predictors of COVID-19 vaccine uptake…
November 23, 2020
Safety and Immunogenicity of ChAdOx1 NCoV-19 Vaccine Administered in a Prime-Boost Regimen in Young and Old Adults (COV002): A Single-Blind, Randomised, Controlled, Phase 2/3 Trial
A novel chimpanzee adenovirus-vectored vaccine, ChAdOx1 nCoV-19, was reported to be safe and well tolerated with reduced reactogenicity in healthy adults aged ≥18 years. A single-blind, randomized phase 2/3 trial in UK (n=552) found that compared to adults who received a control vaccine for meningitis, adults who received ChAdOx1 nCoV-19 developed antibody responses against the…
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