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Topic: Clinical Characteristics and Health Care Setting
February 25, 2021
Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19
In a nationwide case series of 1116 patients <21 years between March and October 2020, 539 were diagnosed with multisystem inflammatory syndrome in children (MIS-C) and 577 were diagnosed with COVID-19. Patients with MIS-C were more likely to be 6-12 years old (41% vs 19%), non-Hispanic Black (32% vs 22%), and have severe cardiovascular symptoms…
February 24, 2021
Invasive Pulmonary Aspergillosis in COVID-19 Critically Ill Patients: Results of a French Monocentric Cohort
The prevalence of invasive pulmonary aspergillosis (IPA) was not higher for mechanically ventilated COVID-19 patients compared to what has been described in other populations with acute respiratory distress syndrome (ARDS), according to a retrospective cohort study. The prevalence of IPA among non-immunocompromised patients in this cohort (n=52 patients) was 3.7%. Most (71%) of the patients…
Patients with Uncomplicated COVID-19 Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale during a Global Pandemic
Persistent COVID-19 symptoms at 3-4 month after infection were found in 82% of patients who had been hospitalized and 64% of those who had not been hospitalized, the most prevalent of which included fatigue and difficulty breathing (dyspnea). Patients were recruited from clinical trials occurring at a single center (Stanford). The majority had mild/moderate COVID-19…
February 23, 2021
Diabetes Is Most Important Cause for Mortality in COVID-19 Hospitalized Patients: Systematic Review and Meta-Analysis
In a systematic review and meta-analysis of 87 articles including over 35,000 patients and almost 6,000 deaths, diabetes mellitus was the best predictor of COVID-19-associated mortality rate after adjusting for confounders including age and gender, followed by chronic pulmonary obstructive disease and malignancies. Corona et al. (Feb 22, 2021). Diabetes Is Most Important Cause for Mortality…
February 22, 2021
Increased Hazard of Mortality in Cases Compatible with SARS-CoV-2 Variant of Concern 2020121 – a Matched Cohort Study
[Pre-print, not peer-reviewed] Findings from a cohort study among people tested for SARS-CoV-2 in community settings in the UK suggest the SARS-CoV-2 B.1.1.7 variant strain is associated with a higher risk of mortality. The hazard ratio for mortality was 1.7 for the variant strain compared to infection with previously circulating strains. This represents an increase…
Densely Sampled Viral Trajectories Suggest Longer Duration of Acute Infection with B.1.1.7 Variant Relative to Non-B.1.1.7 SARS-CoV-2
[Pre-print, not peer-reviewed] A longitudinal assessment of SARS-CoV-2 viral loads from a sample of 65 individuals compared the viral dynamics between individuals with the B.1.1.7 variant (n=7) and non-variant strains. Individuals with the B.1.1.7 variant had a mean duration of the proliferation phase (time from first detection to peak viral load) of 5.3 days, a…
Childhood Asthma Outcomes during the COVID‐19 Pandemic: Findings from the PeARL Multi‐national Cohort
Findings from the PeARL multinational cohort indicate that during the COVID-19 pandemic, children with asthma experienced fewer upper respiratory tract infections (RTIs), episodes of fever, emergency visits, hospital admissions, and asthma attacks and hospitalizations due to asthma than in the preceding year. When compared to non‐asthmatic controls, children with asthma were not at increased risk…
Sequelae in Adults at 6 Months After COVID-19 Infection
A longitudinal prospective cohort study of adults with laboratory-confirmed SARS-CoV-2 infection in Washington State, and a concurrent cohort of healthy (control) patients, found that persistent symptoms were reported up to 9 months after initial infection by 17 of 64 patients (27%) aged 18 to 39 years, 25 of 83 patients (30%) aged 40 to 64…
Higher SARS-CoV-2 Infection Rate in Pregnant Patients
The SARS-CoV-2 infection rate among pregnant individuals in Washington State (13.9/1,000 deliveries) was 70% higher than the rate among similarly-aged adults, which was not completely explained by universal screening at delivery. 240 pregnant patients with PCR-confirmed SARS-CoV-2 infection were identified from March 1-June 3, 2020, and the proportion of cases in pregnancy among most ethnic…
February 19, 2021
Effect of SARS-CoV-2 Infection during the Second Half of Pregnancy on Fetal Growth and Hemodynamics: A Prospective Study
Mild COVID-19 among pregnant people may not contribute to higher risk of developing fetal growth restriction, according to a single-center case-control analysis. Researchers monitored fetal growth and other factors in 49 pregnancies in patients with mild PCR+ cases diagnosed at a median of 31 weeks gestation to a control group of pregnant people who tested…
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