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Topic: Clinical Characteristics and Health Care Setting
January 13, 2021
Impact of Residential Neighborhood and Race/Ethnicity on Outcomes of Hospitalized Patients with COVID-19 in the Bronx
[Pre-print, not peer-reviewed] A single center retrospective observational cohort study of SARS-CoV-2-positive adult residents (n = 977) of the Bronx hospitalized between March-May 2020 found that residing in the South Bronx (OR=1.8), age > 60 years (OR=2.5) and critical COVID-19 (OR=14.6) were significantly associated with mortality. There was no observed difference in 30-day mortality by…
Diarrhea Is Associated with Increased Severity of Disease in COVID-19: Systemic Review and Meta-analysis
A systematic review and meta-analysis (n = 38 studies, 8,407 patients) of COVID-19 gastrointestinal symptoms found that 16% of all patients had at least one GI symptom. The pooled prevalence of nausea/vomiting was 8% and diarrhea was 12%. Patients with diarrhea as one of their presenting symptoms were more likely to have severe disease (OR=1.63)….
Clinical Outcomes and Inflammatory Markers by HIV Serostatus and Viral Suppression in a Large Cohort of Patients Hospitalized With COVID-19
A retrospective cohort study of 4,613 patients positive for SARS-CoV-2 admitted to a hospital in New York City between March 10 and May 11, 2020 found that people living with HIV had increased risk of intubation (aHR=1.73) but similar rates of acute kidney injury and in-hospital death as those without HIV. Most patients were either…
COVID-19 Trends Among Persons Aged 0 – 24 Years — United States
COVID-19 cases in children, adolescents, and young adults increased since summer 2020, with weekly incidence higher in each successively increasing age group. During March 1–December 12, 2020, a total of 2,871,828 laboratory-confirmed cases of COVID-19 in young people aged 0–24 years were reported in the United States, with the majority (57%) occurring among those aged…
January 11, 2021
Impact of Tobacco Smoking on the Risk of COVID-19
A cross-sectional study of sailors on a navy aircraft carrier (n=1688, 87% male) found that current smoking status was associated with a lower risk of COVID-19 (OR = 0.59). 1279 (76%) crewmembers developed COVID-19 (62% RT-PCR positive, 14% with only clinical signs), and crewmembers >50 years old had an increased risk of contracting COVID-19 (OR…
The Importance of Anosmia, Ageusia and Age in Community Presentation of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Louisiana, USA; a Cross-Sectional Prevalence Study
A cross-sectional SARS-CoV-2 seroprevalence study in Louisiana found that reported loss of taste or smell was strongly associated with a positive (PCR or antibody) test (OR: 13.6). Among people who tested positive, 47.3% (147/311) were asymptomatic. Modeling the probability of symptoms showed that the highest probability of reporting symptoms was 64.6% at age 29, which…
Prevalence and Clinical Significance of Persistent Viral Shedding in Hospitalized Adult Patients with SARS-CoV-2 Infection: A Prospective Observational Study
A prospective observational study of adults hospitalized with SARS-CoV-2 infection (n=121) detected persistent viral shedding (PVS) for at least 21 days in up to 38% of patients, which was strongly associated with immunosuppression (6.7% vs 21.7%), increased IL-6 levels (43.4% vs 67.3%), and need for mechanical ventilation (20.0% vs 41.3%). Time from onset of symptoms…
6-Month Consequences of COVID-19 in Patients Discharged from Hospital: A Cohort Study
A cohort study following patients recovering from COVID-19 in Wuhan, China found that fatigue or muscle weakness (63%) and sleep difficulties (26%) were the most commonly reported symptoms during the 6 months post-discharge. Anxiety or depression was reported among 23% of patients. In a comparison of laboratory values during the acute phase of illness versus…
January 8, 2021
Candida Auris Outbreak in a COVID-19 Specialty Care Unit — Florida, July–August 2020
A dedicated COVID-19 specialty care unit at an acute care hospital in Florida reported four fungal infections with Candida auris, which is often resistant to several anti-fungal medications, in July 2020. An additional 35 patients were found to be colonized with C. auris during testing between August 4 and 18. During that time, investigators observed…
January 7, 2021
Compress the Curve: A Cross-Sectional Study of Variations in COVID-19 Infections across California Nursing Homes
Among 713 nursing homes in California, the size of outbreaks in for-profit nursing homes was 12.7 times larger than their non-profit counterparts. Nursing homes with higher ratings on Centers for Medicare & Medicaid Services (CMS) health inspections were associated with a lower number of infections among both staff and residents, while higher self-reported ratings were…
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