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Topic: Clinical Characteristics and Health Care Setting
December 30, 2020
Previous Dengue Infection and Mortality in COVID-19
In a prospective study of 2,351 people with COVID-19 SARS in Brazil, those with previous symptomatic dengue (n=1177) had a lower risk of death after a median follow-up of 60 days (adjusted HR = 0.44). History of other previous infections, including malaria, Zika, and chikungunya, were not associated with mortality. The authors suggest that dengue…
Immune Deficiency Is a Risk Factor for Severe COVID‐19 in People Living with HIV
Among 175 people living with HIV in the UK, US, and Spain, a current CD4 T-cell count of <350 cells/µL was independently associated with a 2.85-fold risk for developing severe COVID-19. A lower nadir CD4 T-cell count of <200 cells/µL was associated with mortality. No significant differences in risk of severe or critical COVID-19 were…
December 28, 2020
Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact
[pre-print; not peer-reviewed] In an international web-based survey of people with suspected or confirmed COVID-19 with illness lasting >28 days (n=3,762) identified 205 symptoms across 10 organ systems. In those who recovered in less than 90 days, the average number of symptoms peaked at week 2, as compared to a peak in month 2 among…
Risks of and Risk Factors for COVID-19 Disease in People with Diabetes: A Cohort Study of the Total Population of Scotland
A study of data from the total population of Scotland (n=5.5 million) found that people with diabetes had a substantially higher risk of dying from COVID-19 or requiring intensive care than the general population. After adjustment for age and sex, people living with Type 2 diabetes had 1.4 times the odds of dying or requiring…
December 23, 2020
Changes in UK Hospital Mortality in the First Wave of COVID-19 the ISARIC WHO Clinical Characterisation Protocol Prospective Multicentre Observational Cohort Study
[pre-print; not peer-reviewed] Among people recently admitted to the hospital with COVID-19 in the United Kingdom, there was a 19% reduction in the odds of mortality compared to the first wave of the epidemic. After adjusting for demographics, comorbidities, and illness severity, the authors compared the mortality observed during a four-week interval in March to…
Epidemiology of COVID-19 Infection in Young Children under Five Years: A Systematic Review and Meta-Analysis
A meta-analysis of laboratory confirmed COVID-19 in children under 5 years of age determined that children were frequently prescribed antibiotics and that the majority of the reported cases were children less than one year old. Bhuiyan et al. identified 65 studies of epidemiological and clinical characteristics of lab-confirmed COVID-19 infections in 1,214 children under age…
Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic
COVID-19 mortality rates in the US declined among hospitalized patients over the first few months of the pandemic with better outcomes associated with low community prevalence of COVID-19, according to a retrospective cohort analysis. The authors constructed a cohort of 38,517 adults from a deidentified administrative database in patients admitted with COVID-19 from January 1…
December 21, 2020
Risk Factors for SARS-CoV-2 Seropositivity in a Health Care Worker Population
[Pre-print, not peer-reviewed] Risk factors for seropositivity among hospital workers (n = 1,557, seropositivity 10.8%) at an academic medical center in California were male gender, exposure to COVID-19 outside of work, working in food or environmental services, and working in COVID-19 units. Seropositive HCWs who were missed by occupational screening were more likely to be…
Increased Care at Discharge from COVID-19: The Association between Pre-Admission Frailty and Increased Care Needs after Hospital Discharge; a Multicentre European Observational Cohort Study
Among patients hospitalized with COVID-19, pre-admission frailty was strongly associated with the need for an increased level of care at discharge in a multicenter observational cohort study in Europe. Among 831 discharged patients (median age = 71 years, 44.4% women), the median length of hospital stay was 12 days, 23.2% had increased care needs at discharge. Vilches-Moraga…
December 18, 2020
Analyses of Abdominal Adiposity and Metabolic Syndrome as Risk Factors for Respiratory Distress in COVID-19
A prospective observational cohort study in the Netherlands indicated that abdominal adiposity was an independent risk factor for respiratory distress in patients with COVID-19 when adjusted for metabolic syndrome, age, gender and BMI (aOR=1.11). Among 86 patients with COVID-19, the prevalence of metabolic syndrome did not differ between patients with or without the need for…
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